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Erschienen in: Clinical and Experimental Nephrology 4/2018

25.01.2018 | Original article

Validation of estimated glomerular filtration rate equations for Japanese children

verfasst von: Yoshimitsu Gotoh, Osamu Uemura, Kenji Ishikura, Tomoyuki Sakai, Yuko Hamasaki, Yoshinori Araki, Riku Hamda, Masataka Honda, On behalf of the Pediatric CKD Study Group in Japan in conjunction with the Committee of Measures for Pediatric CKD of the Japanese Society of Pediatric Nephrology

Erschienen in: Clinical and Experimental Nephrology | Ausgabe 4/2018

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Abstract

Background

The gold standard for evaluation of kidney function is renal inulin clearance (Cin). However, the methodology for Cin is complicated and difficult, especially for younger children and/or patients with bladder dysfunction. Therefore, we developed a simple and easier method for obtaining the estimated glomerular filtration rate (eGFR) using equations and values for several biomarkers, i.e., serum creatinine (Cr), serum cystatin C (cystC), serum beta-2 microglobulin (β2MG), and creatinine clearance (Ccr). The purpose of the present study was to validate these equations with a new data set.

Methods

To validate each equation, we used data of 140 patients with CKD with clinical need for Cin, using the measured GFR (mGFR). We compared the results for each eGFR equation with the mGFR using mean error (ME), root mean square error (RMSE), P30, and Bland–Altman analysis.

Results

The ME of Cr, cystC, β2MG, and Ccr based on eGFR was 15.8 ± 13.0, 17.2 ± 16.5, 15.4 ± 14.3, and 10.6 ± 13.0 ml/min/1.73 m2, respectively. The RMSE was 29.5, 23.8, 20.9, and 16.7, respectively. The P30 was 79.4, 71.1, 69.5, and 92.9%, respectively. The Bland–Altman bias analysis showed values of 4.0 ± 18.6, 5.3 ± 16.8, 12.7 ± 17.0, and 2.5 ± 17.2 ml/min/1.73 m2, respectively, for these parameters.

Conclusion

The bias of each eGFR equation was not large. Therefore, each eGFR equation could be used.
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Metadaten
Titel
Validation of estimated glomerular filtration rate equations for Japanese children
verfasst von
Yoshimitsu Gotoh
Osamu Uemura
Kenji Ishikura
Tomoyuki Sakai
Yuko Hamasaki
Yoshinori Araki
Riku Hamda
Masataka Honda
On behalf of the Pediatric CKD Study Group in Japan in conjunction with the Committee of Measures for Pediatric CKD of the Japanese Society of Pediatric Nephrology
Publikationsdatum
25.01.2018
Verlag
Springer Singapore
Erschienen in
Clinical and Experimental Nephrology / Ausgabe 4/2018
Print ISSN: 1342-1751
Elektronische ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-018-1529-7

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