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Journal of the Association for Research in Otolaryngology

Erschienen in:

01.02.2011

Using the Cochlear Microphonic as a Tool to Evaluate Cochlear Function in Mouse Models of Hearing

verfasst von: Mary Ann Cheatham, Khurram Naik, Peter Dallos

Erschienen in: Journal of the Association for Research in Otolaryngology | Ausgabe 1/2011

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Abstract

The cochlear microphonic (CM) can be a useful analytical tool, but many investigators may not be fully familiar with its unique properties to interpret it accurately in mouse models of hearing. The purpose of this report is to develop a model for generation of the CM in wild-type (WT) and prestin knockout mice. Data and modeling results indicate that in the majority of cases, the CM is a passive response, and in the absence of outer hair cell (OHC) damage, mice lacking amplification are expected to generate WT levels of CM for inputs less than ~30 kHz. Hence, this cochlear potential is not a useful metric to estimate changes in amplifier gain. This modeling analysis may explain much of the paradoxical data in the literature. For example, various manipulations, including the application of salicylate and activation of the crossed olivocochlear bundle, reduce the compound action potential but increase or do not change the CM. Based on this current evaluation, CM measurements are consistent with early descriptions where this AC cochlear potential is dominated by basal OHCs, when recorded at the round window.

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Titel: Using the Cochlear Microphonic as a Tool to Evaluate Cochlear Function in Mouse Models of Hearing
verfasst von: Mary Ann Cheatham
Khurram Naik
Peter Dallos
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: Journal of the Association for Research in Otolaryngology / Ausgabe 1/2011
Print ISSN: 1525-3961
Elektronische ISSN: 1438-7573
DOI: https://doi.org/10.1007/s10162-010-0240-5

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Using the Cochlear Microphonic as a Tool to Evaluate Cochlear Function in Mouse Models of Hearing

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