Skip to main content
Erschienen in: The European Journal of Health Economics 2/2008

01.01.2008 | Original paper

The burden of rheumatoid arthritis and access to treatment: health burden and costs

verfasst von: J. Lundkvist, F. Kastäng, G. Kobelt

Erschienen in: The European Journal of Health Economics | Sonderheft 2/2008

Einloggen, um Zugang zu erhalten

Abstract

As part of the study “The burden of rheumatoid arthritis and patient access to treatment”, this paper reviews evidence on the health burden of rheumatoid arthritis (RA) in terms of morbidity (DALYs), mortality (% of deaths attributable to RA) and quality of life (utility and loss of QALYs), as well as the economic impact on society. Based on available literature on the prevalence and the cost of RA, combined with economic indicators, the annual cost per patient as well as the total national cost is estimated for Europe and North America (Canada and the United States), as well as Australia, Turkey, the Russian Federation and South Africa. Total costs to society were estimated at €45.3 billion in Europe and at €41.6 billion in the United States. Utility scores were found to be amongst the lowest compared to other diseases.
Literatur
1.
Zurück zum Zitat Silman, A.: Epidemiology of rheumatic diseases. Oxford University Press, Oxford (1993) Silman, A.: Epidemiology of rheumatic diseases. Oxford University Press, Oxford (1993)
2.
Zurück zum Zitat Centers for Disease Control and Prevention: Prevalence of arthritis—US 1997. MMWR 50, 334–336, [CD] (2001) Centers for Disease Control and Prevention: Prevalence of arthritis—US 1997. MMWR 50, 334–336, [CD] (2001)
3.
Zurück zum Zitat Guillemin, F., Saraux, A., Guggenbuhl, P., et al.: Prevalence of rheumatoid arthritis in France: 2001. Ann. Rheum. Dis. 64, 1427–1430 (2005)CrossRef Guillemin, F., Saraux, A., Guggenbuhl, P., et al.: Prevalence of rheumatoid arthritis in France: 2001. Ann. Rheum. Dis. 64, 1427–1430 (2005)CrossRef
4.
Zurück zum Zitat Alamanos, Y., Voulgari, P.V., Drosos, A.A.: Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology Criteria: a systematic review. Semin. Arthritis Rheum. 36, 182–188 (2006)CrossRef Alamanos, Y., Voulgari, P.V., Drosos, A.A.: Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology Criteria: a systematic review. Semin. Arthritis Rheum. 36, 182–188 (2006)CrossRef
5.
Zurück zum Zitat Andrianakos, A., Trontzas, P., Christoyannis, F., et al.: Prevalence of rheumatic diseases in Greece: a cross-sectional population-based epidemiological study. The ESORDIG Study. J. Rheumatol. 30, 1589–1601 (2003) Andrianakos, A., Trontzas, P., Christoyannis, F., et al.: Prevalence of rheumatic diseases in Greece: a cross-sectional population-based epidemiological study. The ESORDIG Study. J. Rheumatol. 30, 1589–1601 (2003)
6.
Zurück zum Zitat Carmona, L., Villaverde, V., Hernandez-Garcia, C., et al.: The prevalence of rheumatoid arthritis in the general population of Spain. Rheumatology (Oxford) 41(1), 88–95 (2002)CrossRef Carmona, L., Villaverde, V., Hernandez-Garcia, C., et al.: The prevalence of rheumatoid arthritis in the general population of Spain. Rheumatology (Oxford) 41(1), 88–95 (2002)CrossRef
7.
Zurück zum Zitat Cimmino, M.A., Parisi, M., Moggiana, G., et al.: Prevalence of rheumatoid arthritis in Italy: the Chiavari Study. Ann. Rheum. Dis. 57, 315–318 (1998) Cimmino, M.A., Parisi, M., Moggiana, G., et al.: Prevalence of rheumatoid arthritis in Italy: the Chiavari Study. Ann. Rheum. Dis. 57, 315–318 (1998)
8.
Zurück zum Zitat Drosos, A.A., Alamanos, I., Voulgari, P.V., et al.: Epidemiology of adult rheumatoid arthritis in northwest Greece 1987–1995. J. Rheumatol. 24, 2129–2133 (1997) Drosos, A.A., Alamanos, I., Voulgari, P.V., et al.: Epidemiology of adult rheumatoid arthritis in northwest Greece 1987–1995. J. Rheumatol. 24, 2129–2133 (1997)
9.
Zurück zum Zitat Saraux, A., Guedes, C., Allain, J., et al.: Prevalence of rheumatoid arthritis and spondyloarthropathy in Brittany, France. Societe de Rhumatologie de l’Ouest J. Rheumatol. 26, 2622–2627 (1999) Saraux, A., Guedes, C., Allain, J., et al.: Prevalence of rheumatoid arthritis and spondyloarthropathy in Brittany, France. Societe de Rhumatologie de l’Ouest J. Rheumatol. 26, 2622–2627 (1999)
10.
Zurück zum Zitat Gabriel, S.E., Crowson, C.S., O’Fallon, W.M.: The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955–1985. Arthritis Rheum. 42, 415–420 (1999)CrossRef Gabriel, S.E., Crowson, C.S., O’Fallon, W.M.: The epidemiology of rheumatoid arthritis in Rochester, Minnesota, 1955–1985. Arthritis Rheum. 42, 415–420 (1999)CrossRef
11.
Zurück zum Zitat Hakala, M., Pollanen, R., Nieminen, P.: The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J. Rheumatol. 20, 1674–1678 (1993) Hakala, M., Pollanen, R., Nieminen, P.: The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J. Rheumatol. 20, 1674–1678 (1993)
12.
Zurück zum Zitat Power, D., Codd, M., Ivers, L., et al.: Prevalence of rheumatoid arthritis in Dublin, Ireland: a population based survey. Ir. J. Med. Sci. 168, 197–200 (1999)CrossRef Power, D., Codd, M., Ivers, L., et al.: Prevalence of rheumatoid arthritis in Dublin, Ireland: a population based survey. Ir. J. Med. Sci. 168, 197–200 (1999)CrossRef
13.
Zurück zum Zitat Riise, T., Jacobsen, B.K., Gran, J.T.: Incidence and prevalence of rheumatoid arthritis in the county of Tromsö, northern Norway. J. Rheumatol. 27, 1386–1389 (2000) Riise, T., Jacobsen, B.K., Gran, J.T.: Incidence and prevalence of rheumatoid arthritis in the county of Tromsö, northern Norway. J. Rheumatol. 27, 1386–1389 (2000)
14.
Zurück zum Zitat Simonsson, M., Bergman, S., Jacobsson, L.T., et al.: The prevalence of rheumatoid arthritis in Sweden. Scand. J. Rheumatol. 28, 340–343 (1999)CrossRef Simonsson, M., Bergman, S., Jacobsson, L.T., et al.: The prevalence of rheumatoid arthritis in Sweden. Scand. J. Rheumatol. 28, 340–343 (1999)CrossRef
15.
Zurück zum Zitat Symmons, D., Turner, G., Webb, R., et al.: The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford) 41, 793–800 (2002)CrossRef Symmons, D., Turner, G., Webb, R., et al.: The prevalence of rheumatoid arthritis in the United Kingdom: new estimates for a new century. Rheumatology (Oxford) 41, 793–800 (2002)CrossRef
16.
Zurück zum Zitat Uhlig, T., Kvien, T.K., Glennas, A., et al.: The incidence and severity of rheumatoid arthritis, results from a county register in Oslo, Norway. J, Rheumatol, 25, 1078–1084 (1998) Uhlig, T., Kvien, T.K., Glennas, A., et al.: The incidence and severity of rheumatoid arthritis, results from a county register in Oslo, Norway. J, Rheumatol, 25, 1078–1084 (1998)
17.
Zurück zum Zitat Rasch, E., Hirsch, R., Paulose-Ram, R., Hochberg, M.: Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification. Arthritis Rheum. 48, 917–926 (2003)CrossRef Rasch, E., Hirsch, R., Paulose-Ram, R., Hochberg, M.: Prevalence of rheumatoid arthritis in persons 60 years of age and older in the United States: effect of different methods of case classification. Arthritis Rheum. 48, 917–926 (2003)CrossRef
18.
Zurück zum Zitat Drosos, A., et al.: Rheumatoid Arthritis in Greek and British patients: a comparative clinical, radiologic, and serologic study. Arthritis Rheum. 35, 745–748 (1992)CrossRef Drosos, A., et al.: Rheumatoid Arthritis in Greek and British patients: a comparative clinical, radiologic, and serologic study. Arthritis Rheum. 35, 745–748 (1992)CrossRef
19.
Zurück zum Zitat Antoni, C., Maini, R., Grunke, M., et al.: Cooperative of QoL in Rheumatic disease: results of a survey among 6,000 patients across 11 European countries. Arthritis Rheum 46:ACR (abstract) (2002) Antoni, C., Maini, R., Grunke, M., et al.: Cooperative of QoL in Rheumatic disease: results of a survey among 6,000 patients across 11 European countries. Arthritis Rheum 46:ACR (abstract) (2002)
21.
Zurück zum Zitat Rupp, I., Boshuizen, H.C., Dinant, H.J., et al.: Disability and health-related quality of life among patients with rheumatoid arthritis: association with radiographic joint damage, disease activity, pain, and depressive symptoms. Scand. J. Rheumatol. 35, 175–181 (2006)CrossRef Rupp, I., Boshuizen, H.C., Dinant, H.J., et al.: Disability and health-related quality of life among patients with rheumatoid arthritis: association with radiographic joint damage, disease activity, pain, and depressive symptoms. Scand. J. Rheumatol. 35, 175–181 (2006)CrossRef
22.
Zurück zum Zitat Young, A., Wilkinson, P., Talamo, J., et al.: Socioeconomic deprivation and rheumatoid disease. What lessons for the health service? Ann. Rheum. Dis. 59, 794–799 (2000)CrossRef Young, A., Wilkinson, P., Talamo, J., et al.: Socioeconomic deprivation and rheumatoid disease. What lessons for the health service? Ann. Rheum. Dis. 59, 794–799 (2000)CrossRef
23.
Zurück zum Zitat Kobelt, G., Lindgren, P., Lindroth, Y., Jacobson, L., Eberhardt, K.: Modelling the effect of function and disease activity on costs and quality of life in rheumatoid arthritis. Rheumatology (Oxford) 44, 1169–1175 (2005)CrossRef Kobelt, G., Lindgren, P., Lindroth, Y., Jacobson, L., Eberhardt, K.: Modelling the effect of function and disease activity on costs and quality of life in rheumatoid arthritis. Rheumatology (Oxford) 44, 1169–1175 (2005)CrossRef
24.
Zurück zum Zitat Kobelt, G., Richard, B., Peeters, P., Sany, J.: Costs and quality of life of patients with RA in France. ACR 2006, Bone Joint Spine 75(7), (2008) Kobelt, G., Richard, B., Peeters, P., Sany, J.: Costs and quality of life of patients with RA in France. ACR 2006, Bone Joint Spine 75(7), (2008)
25.
Zurück zum Zitat Currie, C.J., McEwan, P., Peters, J.R., Patel, T.C., Dixon, S.: The routine collation of health outcomes data from hospital-treated subjects in the Health Outcomes Data Repository (HODaR): descriptive analysis from the first 20,000 subjects. Value Health 8, 581–590 (2005)CrossRef Currie, C.J., McEwan, P., Peters, J.R., Patel, T.C., Dixon, S.: The routine collation of health outcomes data from hospital-treated subjects in the Health Outcomes Data Repository (HODaR): descriptive analysis from the first 20,000 subjects. Value Health 8, 581–590 (2005)CrossRef
26.
Zurück zum Zitat Orme, M., Kerrigan, J., Tyas, D., Russell, N., Nixon, R.: The effect of disease, functional status and relapses ont he utility of people with multiple sclerosis in the UK. Value Health 10, 54–60 (2007)CrossRef Orme, M., Kerrigan, J., Tyas, D., Russell, N., Nixon, R.: The effect of disease, functional status and relapses ont he utility of people with multiple sclerosis in the UK. Value Health 10, 54–60 (2007)CrossRef
27.
Zurück zum Zitat Bloom, B.S., Bruno, D.J., Maman, D.Y., Jayadevappa, R.: Usefulness of US cost-of-illness studies in healthcare decision making. Pharmacoeconomics 19, 207–213 (2001)CrossRef Bloom, B.S., Bruno, D.J., Maman, D.Y., Jayadevappa, R.: Usefulness of US cost-of-illness studies in healthcare decision making. Pharmacoeconomics 19, 207–213 (2001)CrossRef
28.
Zurück zum Zitat Koopmanschap, M.A.: Cost-of-illness studies. Useful for health policy? Pharmacoeconomics 14, 143–148 (1998)CrossRef Koopmanschap, M.A.: Cost-of-illness studies. Useful for health policy? Pharmacoeconomics 14, 143–148 (1998)CrossRef
29.
Zurück zum Zitat Cooper, N.J.: Economic burden of rheumatoid arthritis: a systematic review. Rheumatology (Oxford) 39, 28–33 (2000)CrossRef Cooper, N.J.: Economic burden of rheumatoid arthritis: a systematic review. Rheumatology (Oxford) 39, 28–33 (2000)CrossRef
30.
Zurück zum Zitat Pugner, K.M., Scott, D.I., Holmes, J.W., Hieke, K.: The costs of rheumatoid arthritis: an international long-term view. Semin. Arthritis Rheum. 29, 305–220 (2000)CrossRef Pugner, K.M., Scott, D.I., Holmes, J.W., Hieke, K.: The costs of rheumatoid arthritis: an international long-term view. Semin. Arthritis Rheum. 29, 305–220 (2000)CrossRef
31.
Zurück zum Zitat Rosery, H., Bergemann, R., Maxion-Bergemann, S.: International variation in resource utilisation and treatment costs for rheumatoid arthritis: a systematic literature review. Pharmacoeconomics 23, 243–257 (2005)CrossRef Rosery, H., Bergemann, R., Maxion-Bergemann, S.: International variation in resource utilisation and treatment costs for rheumatoid arthritis: a systematic literature review. Pharmacoeconomics 23, 243–257 (2005)CrossRef
32.
Zurück zum Zitat Huscher, D., Merkesdal, S., Thiele, K., et al.: Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann. Rheum. Dis. 65, 1175–1183 (2006)CrossRef Huscher, D., Merkesdal, S., Thiele, K., et al.: Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann. Rheum. Dis. 65, 1175–1183 (2006)CrossRef
33.
Zurück zum Zitat Kirwan, J.R.: Conceptual issues in scoring radiographic progression in rheumatoid arthritis. J. Rheumatol. 26, 720–725 (1999) Kirwan, J.R.: Conceptual issues in scoring radiographic progression in rheumatoid arthritis. J. Rheumatol. 26, 720–725 (1999)
34.
Zurück zum Zitat Landewe, R.B., Boers, M., Verhoeven, A.C., et al.: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum. 46, 347–356 (2002)CrossRef Landewe, R.B., Boers, M., Verhoeven, A.C., et al.: COBRA combination therapy in patients with early rheumatoid arthritis: long-term structural benefits of a brief intervention. Arthritis Rheum. 46, 347–356 (2002)CrossRef
35.
Zurück zum Zitat Kobelt, G., Jonsson, L., Lindgren, P., et al.: Modeling the progression of rheumatoid arthritis: a two-country model to estimate costs and consequences of rheumatoid arthritis. Arthritis Rheum. 46, 2310–2319 (2002)CrossRef Kobelt, G., Jonsson, L., Lindgren, P., et al.: Modeling the progression of rheumatoid arthritis: a two-country model to estimate costs and consequences of rheumatoid arthritis. Arthritis Rheum. 46, 2310–2319 (2002)CrossRef
36.
Zurück zum Zitat Verstappen, S.M., Verkleij, H., Bijlsma, J.W., et al.: Determinants of direct costs in Dutch rheumatoid arthritis patients. Ann. Rheum. Dis. 63, 817–824 (2004)CrossRef Verstappen, S.M., Verkleij, H., Bijlsma, J.W., et al.: Determinants of direct costs in Dutch rheumatoid arthritis patients. Ann. Rheum. Dis. 63, 817–824 (2004)CrossRef
37.
Zurück zum Zitat Hallert, E., Husberg, M., Skogh, T.: Costs and course of disease and function in early rheumatoid arthritis: a 3-year follow-up (the Swedish TIRA project). Rheumatology (Oxford) 45, 325–331 (2006)CrossRef Hallert, E., Husberg, M., Skogh, T.: Costs and course of disease and function in early rheumatoid arthritis: a 3-year follow-up (the Swedish TIRA project). Rheumatology (Oxford) 45, 325–331 (2006)CrossRef
38.
Zurück zum Zitat Michaud, K., Messer, J., Choi, H.K., Wolfe, F.: Direct medical costs and their predictors in patients with rheumatoid arthritis: a three-year study of 7,527 patients. Arthritis Rheum. 48, 2750–2762 (2003)CrossRef Michaud, K., Messer, J., Choi, H.K., Wolfe, F.: Direct medical costs and their predictors in patients with rheumatoid arthritis: a three-year study of 7,527 patients. Arthritis Rheum. 48, 2750–2762 (2003)CrossRef
39.
Zurück zum Zitat Kobelt, G., Eberhardt, K., Jonsson, L., Jonsson, B.: Economic consequences of the progression of rheumatoid arthritis in Sweden. Arthritis Rheum. 42, 347–356 (1999)CrossRef Kobelt, G., Eberhardt, K., Jonsson, L., Jonsson, B.: Economic consequences of the progression of rheumatoid arthritis in Sweden. Arthritis Rheum. 42, 347–356 (1999)CrossRef
40.
Zurück zum Zitat Hulsemann, J.L., Ruof, J., Zeidler, H., Mittendorf, T.: Costs in rheumatology: results and lessons learned from the ‘Hannover Costing Study’. Rheumatol. Int. 26, 704–711 (2006)CrossRef Hulsemann, J.L., Ruof, J., Zeidler, H., Mittendorf, T.: Costs in rheumatology: results and lessons learned from the ‘Hannover Costing Study’. Rheumatol. Int. 26, 704–711 (2006)CrossRef
41.
Zurück zum Zitat Lajas, C., Abasolo, L., Bellajdel, B., et al.: Costs and predictors of costs in rheumatoid arthritis: a prevalence-based study. Arthritis Rheum. 49, 64–70 (2003)CrossRef Lajas, C., Abasolo, L., Bellajdel, B., et al.: Costs and predictors of costs in rheumatoid arthritis: a prevalence-based study. Arthritis Rheum. 49, 64–70 (2003)CrossRef
42.
Zurück zum Zitat Albers, J.M., Kuper, H.H., van Riel, P.L., et al.: Socio-economic consequences of rheumatoid arthritis in the first years of the disease. Rheumatology (Oxford) 38, 423–430 (1999)CrossRef Albers, J.M., Kuper, H.H., van Riel, P.L., et al.: Socio-economic consequences of rheumatoid arthritis in the first years of the disease. Rheumatology (Oxford) 38, 423–430 (1999)CrossRef
43.
Zurück zum Zitat Merkesdal, S., Ruof, J., Schoffski, O., et al.: Indirect medical costs in early rheumatoid arthritis: composition of and changes in indirect costs within the first three years of disease. Arthritis Rheum. 44, 528–534 (2001)CrossRef Merkesdal, S., Ruof, J., Schoffski, O., et al.: Indirect medical costs in early rheumatoid arthritis: composition of and changes in indirect costs within the first three years of disease. Arthritis Rheum. 44, 528–534 (2001)CrossRef
44.
Zurück zum Zitat Young, A., Dixey, J., Cox, N., et al.: How does functional disability in early rheumatoid arthritis (RA) affect patients and their lives? Results of 5 years of follow-up in 732 patients from the Early RA Study (ERAS). Rheumatology (Oxford) 39, 603–611 (2000)CrossRef Young, A., Dixey, J., Cox, N., et al.: How does functional disability in early rheumatoid arthritis (RA) affect patients and their lives? Results of 5 years of follow-up in 732 patients from the Early RA Study (ERAS). Rheumatology (Oxford) 39, 603–611 (2000)CrossRef
45.
Zurück zum Zitat Fex, E., Larsson, B-M., Nived, K., Eberhardt, K.: Impact of rheumatoid arthritis on work status and social and leisure time activities in patients followed 8 years from onset. J. Rheumatol. 25, 44–50 (1997) Fex, E., Larsson, B-M., Nived, K., Eberhardt, K.: Impact of rheumatoid arthritis on work status and social and leisure time activities in patients followed 8 years from onset. J. Rheumatol. 25, 44–50 (1997)
46.
Zurück zum Zitat Merkesdal, S., Huelsemann, J.L., Mittendorf, T., et al.: Productivity costs of rhumatoid arthritis in Germany: cost composition and prediction of main cost components (in German). Z. Rheumatol. 65, 527–534 (2006)CrossRef Merkesdal, S., Huelsemann, J.L., Mittendorf, T., et al.: Productivity costs of rhumatoid arthritis in Germany: cost composition and prediction of main cost components (in German). Z. Rheumatol. 65, 527–534 (2006)CrossRef
47.
Zurück zum Zitat Chorus, A.M., Miedema, H.S., Wevers, C.J., van Der Linden, S.: Labour force participation among patients with rheumatoid arthritis. Ann. Rheum. Dis. 59, 549–554 (2000)CrossRef Chorus, A.M., Miedema, H.S., Wevers, C.J., van Der Linden, S.: Labour force participation among patients with rheumatoid arthritis. Ann. Rheum. Dis. 59, 549–554 (2000)CrossRef
48.
Zurück zum Zitat Young, A., Dixey, J., Kulinskaya, E., et al.: Which patients with early RA stop working? Results from a 5-year inception cohort of 547 patients. Ann. Rheum. Dis. 61, 335–340 (2002)CrossRef Young, A., Dixey, J., Kulinskaya, E., et al.: Which patients with early RA stop working? Results from a 5-year inception cohort of 547 patients. Ann. Rheum. Dis. 61, 335–340 (2002)CrossRef
49.
Zurück zum Zitat Meenan, R.F., Yelin, E.H., Henke, C.J., et al.: The costs of rheumatoid arthritis. A patient-oriented study of chronic disease costs. Arthritis Rheum. 21, 827–833 (1978)CrossRef Meenan, R.F., Yelin, E.H., Henke, C.J., et al.: The costs of rheumatoid arthritis. A patient-oriented study of chronic disease costs. Arthritis Rheum. 21, 827–833 (1978)CrossRef
50.
Zurück zum Zitat Liang, M.H., Larson, M., Thompson, M., et al.: Costs and outcomes in rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 27, 522–529 (1984)CrossRef Liang, M.H., Larson, M., Thompson, M., et al.: Costs and outcomes in rheumatoid arthritis and osteoarthritis. Arthritis Rheum. 27, 522–529 (1984)CrossRef
51.
Zurück zum Zitat Lubeck, D.P., Spitz, P.W., Fries, J.F., et al.: A multicenter study of annual health service utilization and costs in rheumatoid arthritis. Arthritis Rheum. 29, 488–493 (1986)CrossRef Lubeck, D.P., Spitz, P.W., Fries, J.F., et al.: A multicenter study of annual health service utilization and costs in rheumatoid arthritis. Arthritis Rheum. 29, 488–493 (1986)CrossRef
52.
Zurück zum Zitat Wolfe, F., Kleinheksel, S.M., Spitz, P.W., et al.: A multicenter study of hospitalization in rheumatoid arthritis. Frequency, medical-surgical admissions, and charges. Arthritis Rheum. 29, 614–619 (1986)CrossRef Wolfe, F., Kleinheksel, S.M., Spitz, P.W., et al.: A multicenter study of hospitalization in rheumatoid arthritis. Frequency, medical-surgical admissions, and charges. Arthritis Rheum. 29, 614–619 (1986)CrossRef
53.
Zurück zum Zitat Bloom, B.S.: Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis. Am. J. Med. 84, 20–24 (1988)CrossRef Bloom, B.S.: Direct medical costs of disease and gastrointestinal side effects during treatment for arthritis. Am. J. Med. 84, 20–24 (1988)CrossRef
54.
Zurück zum Zitat Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Direct medical costs unique to people with arthritis. J. Rheumatol. 24, 719–725 (1997) Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Direct medical costs unique to people with arthritis. J. Rheumatol. 24, 719–725 (1997)
55.
Zurück zum Zitat Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Indirect and nonmedical costs among people with rheumatoid arthritis and osteoarthritis compared with nonarthritic controls. J. Rheumatol. 24, 43–48 (1997) Gabriel, S.E., Crowson, C.S., Campion, M.E., O’Fallon, W.M.: Indirect and nonmedical costs among people with rheumatoid arthritis and osteoarthritis compared with nonarthritic controls. J. Rheumatol. 24, 43–48 (1997)
56.
Zurück zum Zitat Lanes, S.F., Lanza, L.L., Radensky, P.W., et al.: Resource utilization and cost of care for rheumatoid arthritis and osteoarthritis in a managed care setting: the importance of drug and surgery costs. Arthritis Rheum. 40, 1475–1481 (1997)CrossRef Lanes, S.F., Lanza, L.L., Radensky, P.W., et al.: Resource utilization and cost of care for rheumatoid arthritis and osteoarthritis in a managed care setting: the importance of drug and surgery costs. Arthritis Rheum. 40, 1475–1481 (1997)CrossRef
57.
Zurück zum Zitat Ward, M.M., Javitz, H.S., Yelin, E.H.: The direct cost of rheumatoid arthritis. Value Health 3, 243–252 (2000)CrossRef Ward, M.M., Javitz, H.S., Yelin, E.H.: The direct cost of rheumatoid arthritis. Value Health 3, 243–252 (2000)CrossRef
58.
Zurück zum Zitat Yelin, E.: The costs of rheumatoid arthritis: absolute, incremental, and marginal estimates. J. Rheumatol. 44 (Suppl), 47–51 (1996) Yelin, E.: The costs of rheumatoid arthritis: absolute, incremental, and marginal estimates. J. Rheumatol. 44 (Suppl), 47–51 (1996)
59.
Zurück zum Zitat Yelin, E., Wanke, L.A.: An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline. Arthritis Rheum. 42, 1209–1218 (1999)CrossRef Yelin, E., Wanke, L.A.: An assessment of the annual and long-term direct costs of rheumatoid arthritis: the impact of poor function and functional decline. Arthritis Rheum. 42, 1209–1218 (1999)CrossRef
60.
Zurück zum Zitat Andlin-Sobocki, P., Jonsson, B., Wittchen, H.U., Olesen, J.: Cost of disorders of the brain in Europe. Eur. J. Neurol. 12(Suppl 1), 1–27 (2005) Andlin-Sobocki, P., Jonsson, B., Wittchen, H.U., Olesen, J.: Cost of disorders of the brain in Europe. Eur. J. Neurol. 12(Suppl 1), 1–27 (2005)
61.
62.
Zurück zum Zitat Eurostat (2006) Economy and finance, Brussels Eurostat (2006) Economy and finance, Brussels
64.
Zurück zum Zitat Kobelt, G., Berg, J., Lindgren, P., Fredrikson, S., Jönsson, B.: Costs and quality of life of multiple sclerosis in Europe. J. Neurol. Neurosurg. Psychiatry 77, 918–926 (2006)CrossRef Kobelt, G., Berg, J., Lindgren, P., Fredrikson, S., Jönsson, B.: Costs and quality of life of multiple sclerosis in Europe. J. Neurol. Neurosurg. Psychiatry 77, 918–926 (2006)CrossRef
65.
Zurück zum Zitat Wagner, E., Lackerbauer, E., Siegmeth, W.: Direct and indirect costs of rheumatoid arthritis and the socio-emotional effects of this disease—an Austrian study (in German). Wien Med Wochenschr 155, 217–226 (2005)CrossRef Wagner, E., Lackerbauer, E., Siegmeth, W.: Direct and indirect costs of rheumatoid arthritis and the socio-emotional effects of this disease—an Austrian study (in German). Wien Med Wochenschr 155, 217–226 (2005)CrossRef
66.
Zurück zum Zitat Westhovens, R., Boonen, A., Verbruggen, L., et al.: Healthcare consumption and direct costs of rheumatoid arthritis in Belgium. Clin. Rheumatol. 24, 615–619 (2005)CrossRef Westhovens, R., Boonen, A., Verbruggen, L., et al.: Healthcare consumption and direct costs of rheumatoid arthritis in Belgium. Clin. Rheumatol. 24, 615–619 (2005)CrossRef
67.
Zurück zum Zitat Maetzel, A., Li, L.C., Pencharz, J., et al.: The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann. Rheum. Dis. 63, 395–401 (2004)CrossRef Maetzel, A., Li, L.C., Pencharz, J., et al.: The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann. Rheum. Dis. 63, 395–401 (2004)CrossRef
68.
Zurück zum Zitat Sorensen, J.: Health care costs attributable to the treatment of rheumatoid arthritis. Scand. J. Rheumatol. 33, 399–404 (2004)CrossRef Sorensen, J.: Health care costs attributable to the treatment of rheumatoid arthritis. Scand. J. Rheumatol. 33, 399–404 (2004)CrossRef
69.
Zurück zum Zitat Leardini, G., Salaffi, F., Montanelli, R., et al.: A multicenter cost-of-illness study on rheumatoid arthritis in Italy. Clin. Exp. Rheumatol. 20, 505–515 (2002) Leardini, G., Salaffi, F., Montanelli, R., et al.: A multicenter cost-of-illness study on rheumatoid arthritis in Italy. Clin. Exp. Rheumatol. 20, 505–515 (2002)
70.
Zurück zum Zitat Verstappen, S.M., Jacobs, J.W., van der Heijde, D.M., et al.: Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis. Ann. Rheum. Dis. (2006) Verstappen, S.M., Jacobs, J.W., van der Heijde, D.M., et al.: Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis. Ann. Rheum. Dis. (2006)
71.
Zurück zum Zitat Jacobsson, L.T., Lindroth, Y., Marsal, L., Juran, E., Bergstrom, U., Kobelt, G.: Rheumatoid arthritis: what does it cost and what factors are driving those costs? Results of a survey in a community-derived population in Malmo, Sweden. Scand. J. Rheumatol. 36, 179–183 (2007)CrossRef Jacobsson, L.T., Lindroth, Y., Marsal, L., Juran, E., Bergstrom, U., Kobelt, G.: Rheumatoid arthritis: what does it cost and what factors are driving those costs? Results of a survey in a community-derived population in Malmo, Sweden. Scand. J. Rheumatol. 36, 179–183 (2007)CrossRef
72.
Zurück zum Zitat Kobelt, G., Lindgren, P., Singh, A., Klareskog, L.: Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial. Ann. Rheum. Dis. 64, 1174–1179 (2005)CrossRef Kobelt, G., Lindgren, P., Singh, A., Klareskog, L.: Cost effectiveness of etanercept (Enbrel) in combination with methotrexate in the treatment of active rheumatoid arthritis based on the TEMPO trial. Ann. Rheum. Dis. 64, 1174–1179 (2005)CrossRef
73.
Zurück zum Zitat McIntosh, E.: The cost of rheumatoid arthritis. Br. J. Rheumatol. 35, 781–790 (1996)CrossRef McIntosh, E.: The cost of rheumatoid arthritis. Br. J. Rheumatol. 35, 781–790 (1996)CrossRef
74.
Zurück zum Zitat Sobocki, P., Pugliatti, M., Lauer, L., Kobelt, G.: Estimation of the cost of MS in Europe: extrapolations from a multinational cost study. Mult. Scler. 13, 1054–1064 (2007)CrossRef Sobocki, P., Pugliatti, M., Lauer, L., Kobelt, G.: Estimation of the cost of MS in Europe: extrapolations from a multinational cost study. Mult. Scler. 13, 1054–1064 (2007)CrossRef
Metadaten
Titel
The burden of rheumatoid arthritis and access to treatment: health burden and costs
verfasst von
J. Lundkvist
F. Kastäng
G. Kobelt
Publikationsdatum
01.01.2008
Verlag
Springer-Verlag
Erschienen in
The European Journal of Health Economics / Ausgabe Sonderheft 2/2008
Print ISSN: 1618-7598
Elektronische ISSN: 1618-7601
DOI
https://doi.org/10.1007/s10198-007-0088-8

Weitere Artikel der Sonderheft 2/2008

The European Journal of Health Economics 2/2008 Zur Ausgabe