Introduction
Methods
Study design
Data collection: patient survey
Data collection: general population survey
Utility assessment
Health state vignettes
Time trade-off (TTO)
Statistical analyses
Results
Demographic and clinical characteristics of the study populations
Variables | Mean (SD) or N (%) | p value | |
---|---|---|---|
Patients with CD (n = 206) | General population sample (n = 221) | ||
Sex | |||
Female | 93 (45.1%) | 71 (32.1%) | < 0.001 |
Male | 113 (54.9%) | 150 (67.9%) | |
Age (years) | 34.7 (10.5) | 37.3 (15.5) | < 0.001 |
Age groups (years) | |||
18–24 | 37 (18.0%) | 75 (33.9%) | < 0.001 |
25–34 | 71 (34.5%) | 39 (17.6%) | |
35–44 | 59 (28.6%) | 27 (12.2%) | |
≥ 45 | 39 (18.9%) | 80 (36.2%) | |
Education (n = 1) | |||
Primary school | 14 (6.8%) | 4 (1.8%) | < 0.001 |
Secondary school | 132 (71.2%) | 93 (42.1%) | |
College/university | 59 (28.8%) | 124 (56.1%) | |
Employment | |||
Student | 25 (12.1%) | 63 (28.5%) | < 0.001 |
Full time | 110 (53.4%) | 100 (45.2%) | 0.092 |
Part time | 30 (14.6%) | 21 (9.5%) | 0.107 |
Unemployed | 11 (5.3%) | 9 (4.1%) | 0.536 |
Retired | 3 (1.5%) | 12 (5.4%) | 0.026 |
Disability pensioner | 49 (23.8%) | 4 (1.8%) | < 0.001 |
Other | 15 (7.3%) | 12 (5.4%) | 0.424 |
Place of residence | |||
Capital (Budapest) | 45 (21.8%) | 102 (46.2%) | < 0.001 |
County town | 34 (16.5%) | 24 (10.9%) | 0.089 |
Smaller town | 81 (39.3%) | 63 (28.5%) | 0.018 |
Village | 46 (22.3%) | 32 (14.5%) | 0.036 |
Subjective life expectancy (years) | 76.3 (12.4) | 79.0 (11.0) | 0.019 |
Prior experiences with CD of participants from the general population | |||
Have never heard about it | N/A | 153 (69.2%) | N/A |
Have heard about ita | N/A | 68 (30.8%) | N/A |
Have been diagnosed with CD | N/A | 8 (3.6%) | N/A |
Have a family member or acquaintance with CD | N/A | 9 (4.1%) | N/A |
Doctor | N/A | 9 (4.1%) | N/A |
Employed in healthcare (but not a doctor) | N/A | 10 (4.5%) | N/A |
Medical student | N/A | 1 (0.5%) | N/A |
Read/heard about it from the Internet/media/newspaper | N/A | 37 (16.7%) | N/A |
Other | N/A | 5 (2.3%) | N/A |
Mean (SD) or N (%) | |
---|---|
Body mass index, BMI (kg/m2) (missing n = 2) | 23.4 (4.3) |
Underweight (BMI > 18.5) | 22 (10.8%) |
Normal (BMI 18.5–24.9) | 111 (54.4%) |
Overweight (BMI 25.0–29.9) | 57 (27.9%) |
Obesity (BMI > 30) | 14 (6.9%) |
Extraintestinal manifestations | 57 (27.7%) |
Disease severity: CDAI (0–600) | 110.5 (77.0) |
Symptomatic remission (CDAI < 150) | 156 (75.7%) |
Mild (CDAI 150–219) | 32 (15.5%) |
Moderate to severe (CDAI 220 ≤) | 18 (8.7%) |
Perianal fistula severity: PDAI (0–20) (missing n = 1) | 3.68 (2.29) |
Inactive (PDAI ≤ 4) | 53 (63.9%) |
Active (PDAI > 4) | 30 (36.1%) |
Pain | |
Pain VAS (0–100) | 24.7 (23.9) |
Current treatment | |
None | 3 (1.5%) |
Systemic non-biological | 67 (32.5%) |
Biological | 136 (66.0%) |
Previous surgeries due to CDa | |
None | 87 (42.2%) |
Resection surgery | 66 (32.0%) |
Non-resection surgeryb | 86 (41.7%) |
Utility results
Health state | Patients | General population | p value* | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
N
| Mean (SD) | Median (IQR) | ‘0’ utilities (N, %) | ‘1’ utilities (N, %) |
N
| Mean (SD) | Median (IQR) | ‘0’ utilities (N, %) | ‘1’ utilities (N, %) | ||
Severe luminal disease (sCD) | 199 | 0.73 (0.31) | 0.90 (0.50–1) | 4 (2.0%) | 60 (30.2%) | 221 | 0.65 (0.29) | 0.70 (0.50–0.90) | 13 (5.9%) | 22 (10.0%) | 0.005 |
Mild luminal disease (mCD) | 199 | 0.87 (0.26) | 1 (0.90–1) | 3 (1.5%) | 116 (58.3%) | 221 | 0.88 (0.25) | 1 (0.90–1) | 10 (4.5%) | 123 (55.7%) | 0.919 |
Severe luminal disease with active perianal fistulas (sPFCD) | 197 | 0.69 (0.33) | 0.80 (0.50–1) | 8 (4.1%) | 55 (27.9%) | 221 | 0.59 (0.31) | 0.65 (0.40–0.85) | 17 (7.7%) | 20 (9.0%) | 0.002 |
Mild luminal disease with active perianal fistulas (mPFCD) | 193 | 0.80 (0.29) | 0.90 (0.70–1) | 5 (2.6%) | 74 (38.3%) | 221 | 0.80 (0.26) | 0.90 (0.80–1) | 8 (3.6%) | 66 (29.9%) | 0.794 |
Current health | 201 | 0.83 (0.28) | 1 (0.80–1) | 4 (2.0%) | 103 (51.2%) | N/A | N/A | N/A | N/A | N/A | N/A |
Variables | Groups |
N
| Mean (SD) | p value |
---|---|---|---|---|
Disease severity | Symptomatic remission (CDAI < 150) | 153 | 0.85 (0.27) | 0.086 |
Mild (CDAI 150–219) | 31 | 0.84 (0.33) | ||
Moderate to severe (CDAI 220 ≤) | 17 | 0.69 (0.34) | ||
Perianal fistulas | Inactive (PDAI ≤ 4) or no | 172 | 0.86 (0.26) | 0.013 |
Active (PDAI > 4) | 29 | 0.67 (0.37) | ||
Extraintestinal manifestations | No | 146 | 0.85 (0.26) | 0.858 |
Yes | 55 | 0.82 (0.29) | ||
Current treatment | Non-biological | 66 | 0.87 (0.25) | 0.139 |
Biological | 132 | 0.81 (0.30) | ||
Previous surgeries due to CD | None | 86 | 0.89 (0.20) | 0.023 |
Resection | 31 | 0.87 (0.26) | ||
Non-resection | 51 | 0.76 (0.33) | ||
Both | 33 | 0.75 (0.37) |