Skip to main content
Erschienen in: Clinical Autonomic Research 2/2017

20.02.2017 | Short Communication

Is cerebral vasomotor reactivity impaired in Parkinson disease?

verfasst von: Martha F. Hanby, Ronney B. Panerai, Thompson G. Robinson, Victoria J. Haunton

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2017

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The ability of a blood vessel to change diameter in response to a change in carbon dioxide concentration is often referred to as vasomotor reactivity. This study aimed to determine whether vasomotor reactivity is impaired in patients with idiopathic Parkinson's Disease in comparison to healthy controls.

Methods

Transcranial Doppler was used to measure cerebral blood flow velocity in the middle cerebral arteries at baseline and under hypocapnic conditions in 40 patients with idiopathic Parkinson's disease and 50 healthy controls.

Results/Conclusions

Vasomotor reactivity, assessed under hypocapnic conditions, is not impaired in patients with idiopathic Parkinson's Disease in comparison to healthy controls.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Markwalder TM, Grolimund P, Seiler RW, Roth F, Aaslid R (1984) Dependency of blood flow velocity in the middle cerebral artery on end-tidal carbon dioxide partial pressure—a transcranial ultrasound Doppler study. J Cereb Blood Flow Metab 4:368–372CrossRefPubMed Markwalder TM, Grolimund P, Seiler RW, Roth F, Aaslid R (1984) Dependency of blood flow velocity in the middle cerebral artery on end-tidal carbon dioxide partial pressure—a transcranial ultrasound Doppler study. J Cereb Blood Flow Metab 4:368–372CrossRefPubMed
2.
Zurück zum Zitat Edvinsson L, Sercombe R (1976) Influence of pH and PaCO2 on alpha-receptor mediated contraction in brain vessels. Acta Physiol Scand 97:325–331CrossRefPubMed Edvinsson L, Sercombe R (1976) Influence of pH and PaCO2 on alpha-receptor mediated contraction in brain vessels. Acta Physiol Scand 97:325–331CrossRefPubMed
3.
Zurück zum Zitat Pebbles KC, Ball OG, MacRae BA et al (2012) Sympathetic regulation of the human cerebrovascular response to carbon dioxide. J Appl Physiol 113:700–706CrossRef Pebbles KC, Ball OG, MacRae BA et al (2012) Sympathetic regulation of the human cerebrovascular response to carbon dioxide. J Appl Physiol 113:700–706CrossRef
5.
Zurück zum Zitat Panerai RB (2003) The critical closing pressure of the cerebral circulation. Med Eng Phys 25:621–632CrossRefPubMed Panerai RB (2003) The critical closing pressure of the cerebral circulation. Med Eng Phys 25:621–632CrossRefPubMed
6.
Zurück zum Zitat Tiecks FP, Lam AM, Aaslid R, Newell DW (1995) Comparison on static and dynamic cerebral autoregulation measurements. Stroke 26:1014–1019CrossRefPubMed Tiecks FP, Lam AM, Aaslid R, Newell DW (1995) Comparison on static and dynamic cerebral autoregulation measurements. Stroke 26:1014–1019CrossRefPubMed
7.
Zurück zum Zitat Carrera E, Lee LK, Giannopoulos S, Marshall RS (2009) Cerebrovascular reactivity and cerebral autoregulation in normal subjects. J Neurol Sci 285:191–194CrossRefPubMed Carrera E, Lee LK, Giannopoulos S, Marshall RS (2009) Cerebrovascular reactivity and cerebral autoregulation in normal subjects. J Neurol Sci 285:191–194CrossRefPubMed
8.
Zurück zum Zitat Dineen NE, Brodie FG, Robinson TG, Panerai RB (2010) Continuous estimates of dynamic cerebral autoregulation during transient hypocapnia or hypercapnia. J Appl Physiol 108:604–613CrossRefPubMed Dineen NE, Brodie FG, Robinson TG, Panerai RB (2010) Continuous estimates of dynamic cerebral autoregulation during transient hypocapnia or hypercapnia. J Appl Physiol 108:604–613CrossRefPubMed
9.
Zurück zum Zitat Douglas J, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinsonʼs disease. Arch Neurol 56:33–39CrossRef Douglas J, Oliver E, Gilman S (1999) Diagnostic criteria for Parkinsonʼs disease. Arch Neurol 56:33–39CrossRef
10.
Zurück zum Zitat Hoehn M, Yahr M (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442CrossRefPubMed Hoehn M, Yahr M (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442CrossRefPubMed
11.
Zurück zum Zitat Fahr S, Elton RL (1987) UPDRS program members. Unified Parkinsonʼs disease rating scale. In: Fahr S, Marsden CD, Goldstein M, Calne DB (eds) Recent developments in Parkinson’s disease, vol 2. Macmillan Healthcare Information, Florham Park, pp 153–163 Fahr S, Elton RL (1987) UPDRS program members. Unified Parkinsonʼs disease rating scale. In: Fahr S, Marsden CD, Goldstein M, Calne DB (eds) Recent developments in Parkinson’s disease, vol 2. Macmillan Healthcare Information, Florham Park, pp 153–163
12.
Zurück zum Zitat Krainik A, Maillet A, Fleury V et al (2013) Levodopa does not change cerebral vasoreactivity in Parkinsonʼs disease. Mov Disord 28:469–475CrossRefPubMed Krainik A, Maillet A, Fleury V et al (2013) Levodopa does not change cerebral vasoreactivity in Parkinsonʼs disease. Mov Disord 28:469–475CrossRefPubMed
13.
Zurück zum Zitat Al-Bachari S, Parkes LM, Vidyasagar R et al (2014) Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinsonʼs disease. Neuroimage 6:1–8CrossRefPubMedPubMedCentral Al-Bachari S, Parkes LM, Vidyasagar R et al (2014) Arterial spin labelling reveals prolonged arterial arrival time in idiopathic Parkinsonʼs disease. Neuroimage 6:1–8CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Gurevich T, Gur AY, Bornstein NM, Giladi N, Korczyn AD (2006) Cerebral vasomotor reactivity in Parkinsonʼs disease, multiple system atrophy and pure autonomic failure. J Neurol Sci 243:57–60CrossRefPubMed Gurevich T, Gur AY, Bornstein NM, Giladi N, Korczyn AD (2006) Cerebral vasomotor reactivity in Parkinsonʼs disease, multiple system atrophy and pure autonomic failure. J Neurol Sci 243:57–60CrossRefPubMed
15.
Zurück zum Zitat Zamani B, Mehrnoush M, Fereshtehnejad SM, Rohani M (2011) Evaluation of cerebral vasomotor reactivity in Parkinsonʼs disease: is there any association with orthostatic hypotension. Clin Neurol Neurosurg 113:368–372CrossRefPubMed Zamani B, Mehrnoush M, Fereshtehnejad SM, Rohani M (2011) Evaluation of cerebral vasomotor reactivity in Parkinsonʼs disease: is there any association with orthostatic hypotension. Clin Neurol Neurosurg 113:368–372CrossRefPubMed
16.
Zurück zum Zitat Hamdy MM, Sadallal HM, Elsalamawy DH (2012) The study of vasoreactivity of the cerebral vessels in patients with Parkinsonʼs disease. Egyptian J Neurol Psych Neurosurg 49:353–357 Hamdy MM, Sadallal HM, Elsalamawy DH (2012) The study of vasoreactivity of the cerebral vessels in patients with Parkinsonʼs disease. Egyptian J Neurol Psych Neurosurg 49:353–357
Metadaten
Titel
Is cerebral vasomotor reactivity impaired in Parkinson disease?
verfasst von
Martha F. Hanby
Ronney B. Panerai
Thompson G. Robinson
Victoria J. Haunton
Publikationsdatum
20.02.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Autonomic Research / Ausgabe 2/2017
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI
https://doi.org/10.1007/s10286-017-0406-x

Weitere Artikel der Ausgabe 2/2017

Clinical Autonomic Research 2/2017 Zur Ausgabe