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Magnetic Resonance Materials in Physics, Biology and Medicine

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01.12.2014 | Research Article

Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner

verfasst von: Anja Müller-Lutz, Nadia Khalil, Benjamin Schmitt, Vladimir Jellus, Gael Pentang, Georg Oeltzschner, Gerald Antoch, Rotem S. Lanzman, Hans-Jörg Wittsack

Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine | Ausgabe 6/2014

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Abstract

Objective

The objective of this study was to show the feasibility to perform Iopamidol-based pH imaging via clinical 3T magnetic resonance imaging (MRI) using chemical exchange saturation transfer (CEST) imaging with pulse train presaturation.

Materials and methods

The pulse train presaturation scheme of a CEST sequence was investigated for Iopamidol-based pH measurements using a 3T magnetic resonance (MR) scanner. The CEST sequence was applied to eight tubes filled with 100-mM Iopamidol solutions with pH values ranging from 5.6 to 7.0. Calibration curves for pH quantification were determined. The dependence of pH values on the concentration of Iopamidol was investigated. An in vivo measurement was performed in one patient who had undergone a previous contrast-enhanced computed tomography (CT) scan with Iopamidol. The pH values of urine measured with CEST MRI and with a pH meter were compared.

Results

In the measured pH range, pH imaging using CEST imaging with pulse train presaturation was possible. Dependence between the pH value and the concentration of Iopamidol was not observed. In the in vivo investigation, the pH values in the human bladder measured by the Iopamidol CEST sequence and in urine were consistent.

Conclusion

Our study shows the feasibility of using CEST imaging with Iopamidol for quantitative pH mapping in vitro and in vivo on a 3T MR scanner.

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Titel: Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner
verfasst von: Anja Müller-Lutz
Nadia Khalil
Benjamin Schmitt
Vladimir Jellus
Gael Pentang
Georg Oeltzschner
Gerald Antoch
Rotem S. Lanzman
Hans-Jörg Wittsack
Publikationsdatum: 01.12.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Magnetic Resonance Materials in Physics, Biology and Medicine / Ausgabe 6/2014
Print ISSN: 0968-5243
Elektronische ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-014-0433-8

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Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner

Abstract

Objective

Materials and methods

Results

Conclusion

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

Objective

Materials and methods

Results

Conclusion

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