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Accuracy of a Mitral Valve Segmentation Method Using J-Splines for Real-Time 3D Echocardiography Data

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Abstract

Patient-specific models of the heart’s mitral valve (MV) exhibit potential for surgical planning. While advances in 3D echocardiography (3DE) have provided adequate resolution to extract MV leaflet geometry, no study has quantitatively assessed the accuracy of their modeled leaflets vs. a ground-truth standard for temporal frames beyond systolic closure or for differing valvular dysfunctions. The accuracy of a 3DE-based segmentation methodology based on J-splines was assessed for porcine MVs with known 4D leaflet coordinates within a pulsatile simulator during closure, peak closure, and opening for a control, prolapsed, and billowing MV model. For all time points, the mean distance error between the segmented models and ground-truth data were 0.40 ± 0.32 mm, 0.52 ± 0.51 mm, and 0.74 ± 0.69 mm for the control, flail, and billowing models. For all models and temporal frames, 95% of the distance errors were below 1.64 mm. When applied to a patient data set, segmentation was able to confirm a regurgitant orifice and post-operative improvements in coaptation. This study provides an experimental platform for assessing the accuracy of an MV segmentation methodology at phases beyond systolic closure and for differing MV dysfunctions. Results demonstrate the accuracy of a MV segmentation methodology for the development of future surgical planning tools.

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Abbreviations

MV:

Mitral valve

3DE:

Three-dimensional echocardiography

rt-3DE:

Real-time three-dimensional echocardiography

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Acknowledgments

This study was supported by a research grant awarded by the National Institutes of Health (R01HL090661). The authors acknowledge Philips Medical Systems for their technical support in this study. The authors also acknowledge Holifield Farms for providing the porcine hearts used in this study.

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Authors and Affiliations

  1. Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Dr., Atlanta, GA, 30332, USA

    Andrew W. Siefert, David A. Icenogle, Jean-Pierre M. Rabbah, Neelakantan Saikrishnan, Stamatios Lerakis & Ajit P. Yoganathan

  2. College of Computing, Georgia Institute of Technology, Atlanta, GA, USA

    Jarek Rossignac

  3. Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA

    Stamatios Lerakis

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  1. Andrew W. Siefert
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  2. David A. Icenogle
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Correspondence to Ajit P. Yoganathan.

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Associate Editor Nathalie Virag oversaw the review of this article.

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Siefert, A.W., Icenogle, D.A., Rabbah, JP.M. et al. Accuracy of a Mitral Valve Segmentation Method Using J-Splines for Real-Time 3D Echocardiography Data. Ann Biomed Eng 41, 1258–1268 (2013). https://doi.org/10.1007/s10439-013-0784-8

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