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01.11.2011 | Original Paper

Computer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project

verfasst von: Jeffrey D. Fisher, K. Rivet Amico, William A. Fisher, Deborah H. Cornman, Paul A. Shuper, Cynthia Trayling, Caroline Redding, William Barta, Anthony F. Lemieux, Frederick L. Altice, Kevin Dieckhaus, Gerald Friedland, for the LifeWindows Team

Erschienen in: AIDS and Behavior | Ausgabe 8/2011

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Abstract

We evaluated the efficacy of LifeWindows, a theory-based, computer-administered antiretroviral (ARV) therapy adherence support intervention, delivered to HIV + patients at routine clinical care visits. 594 HIV + adults receiving HIV care at five clinics were randomized to intervention or control arms. Intervention vs. control impact in the intent-to-treat sample (including participants whose ARVs had been entirely discontinued, who infrequently attended care, or infrequently used LifeWindows) did not reach significance. Intervention impact in the On Protocol sample (328 intervention and control arm participants whose ARVs were not discontinued, who attended care and were exposed to LifeWindows regularly) was significant. On Protocol intervention vs. control participants achieved significantly higher levels of perfect 3-day ACTG-assessed adherence over time, with sensitivity analyses maintaining this effect down to 70% adherence. This study supports the utility of LifeWindows and illustrates that patients on ARVs who persist in care at clinical care sites can benefit from adherence promotion software.

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Assays varied between clinics and also within clinics over time. In order to equalize results from assays of varying sensitivity, we selected the highest minimum-detection threshold used (HIV-1 RNA ≤ 400 copies/ml) to define "undetectable" viral load.

Adherence assessments were not conducted at visits where patients' medical records indicated complete discontinuation of all ARVs.

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Titel: Computer-Based Intervention in HIV Clinical Care Setting Improves Antiretroviral Adherence: The LifeWindows Project
verfasst von: Jeffrey D. Fisher
K. Rivet Amico
William A. Fisher
Deborah H. Cornman
Paul A. Shuper
Cynthia Trayling
Caroline Redding
William Barta
Anthony F. Lemieux
Frederick L. Altice
Kevin Dieckhaus
Gerald Friedland
for the LifeWindows Team
Publikationsdatum: 01.11.2011
Verlag: Springer US
Erschienen in: AIDS and Behavior / Ausgabe 8/2011
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI: https://doi.org/10.1007/s10461-011-9926-x

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