Skip to main content
Erschienen in: AIDS and Behavior 4/2014

01.04.2014 | Original Paper

The Use of Cell Phone Support for Non-adherent HIV-Infected Youth and Young Adults: An Initial Randomized and Controlled Intervention Trial

verfasst von: Marvin E. Belzer, Sylvie Naar-King, Johanna Olson, Moussa Sarr, Sarah Thornton, Shoshana Y. Kahana, Aditya H. Gaur, Leslie F. Clark, The Adolescent Medicine Trials Network for HIV/AIDS Interventions

Erschienen in: AIDS and Behavior | Ausgabe 4/2014

Einloggen, um Zugang zu erhalten

Abstract

This randomized behavioral trial examined whether youth living with HIV (YLH) receiving cell-phone support with study funded phone plans, demonstrated improved adherence and viral control during the 24 week intervention and 24 weeks post-intervention compared to controls. Monday through Friday phone calls confirmed medications were taken, provided problem-solving support, and referred to services to address adherence barriers. Of 37 participants (ages 15–24), 62 % were male and 70 % were African American. Self-reported adherence was significantly higher in the intervention group compared to the control at 24 and 48 weeks for the past month (P = 0.007) and log 10 HIV VL was significantly lower at both 24 weeks (2.82 versus 4.52 P = 0.002) and 48 weeks (3.23 versus 4.23 P = 0.043). Adherence and viral load showed medium to large effect sizes across the 48 week study. This is the first study to demonstrate sustained clinically significant reductions in HIV VL using youth friendly technology.
Literatur
1.
Zurück zum Zitat Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.PubMedCentralPubMedCrossRef Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365(6):493–505.PubMedCentralPubMedCrossRef
2.
Zurück zum Zitat Belzer ME, OJ. Adherence in adolescents: a review of the literature. Adolescent medicine: state of the art reviews evaluation and management of adolescent issues. [Review article]. 2008;19(1):99–118. Belzer ME, OJ. Adherence in adolescents: a review of the literature. Adolescent medicine: state of the art reviews evaluation and management of adolescent issues. [Review article]. 2008;19(1):99–118.
3.
Zurück zum Zitat Policy TWHOoNA. National HIV/AIDS strategy for the United States. Washington DC 2010. Policy TWHOoNA. National HIV/AIDS strategy for the United States. Washington DC 2010.
4.
Zurück zum Zitat Comulada WS, Swendeman DT, Rotheram-Borus MJ, Mattes KM, Weiss RE. Use of HAART among young people living with HIV. Am J Health Behav. 2003;27(4):389–400.PubMedCentralPubMedCrossRef Comulada WS, Swendeman DT, Rotheram-Borus MJ, Mattes KM, Weiss RE. Use of HAART among young people living with HIV. Am J Health Behav. 2003;27(4):389–400.PubMedCentralPubMedCrossRef
5.
Zurück zum Zitat Macdonell KE, Naar-King S, Murphy DA, Parsons JT, Harper GW. Predictors of medication adherence in high risk youth of color living with HIV. J Pediatr Psychol. 2010;35(6):593–601.PubMedCentralPubMedCrossRef Macdonell KE, Naar-King S, Murphy DA, Parsons JT, Harper GW. Predictors of medication adherence in high risk youth of color living with HIV. J Pediatr Psychol. 2010;35(6):593–601.PubMedCentralPubMedCrossRef
6.
Zurück zum Zitat Murphy DA, Sarr M, Durako SJ, Moscicki AB, Wilson CM, Muenz LR, et al. Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. Arch Pediatr Adolesc Med. 2003;157(3):249–55.PubMedCrossRef Murphy DA, Sarr M, Durako SJ, Moscicki AB, Wilson CM, Muenz LR, et al. Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. Arch Pediatr Adolesc Med. 2003;157(3):249–55.PubMedCrossRef
7.
Zurück zum Zitat MacDonell K, Naar-King S, Huszti H, Belzer M. Barriers to medication adherence in behaviorally and perinatally infected youth living with HIV. AIDS behav. 2013;17(1):86–93.PubMedCentralPubMedCrossRef MacDonell K, Naar-King S, Huszti H, Belzer M. Barriers to medication adherence in behaviorally and perinatally infected youth living with HIV. AIDS behav. 2013;17(1):86–93.PubMedCentralPubMedCrossRef
8.
Zurück zum Zitat Gaur AH, Belzer M, Britto P, Garvie PA, Hu CC, Graham B, et al. Directly observed therapy (DOT) for nonadherent HIV-infected youth: lessons learned challenges ahead. Aids Res Hum Retrov. 2010;26(9):947–53.CrossRef Gaur AH, Belzer M, Britto P, Garvie PA, Hu CC, Graham B, et al. Directly observed therapy (DOT) for nonadherent HIV-infected youth: lessons learned challenges ahead. Aids Res Hum Retrov. 2010;26(9):947–53.CrossRef
9.
Zurück zum Zitat Garvie PA, Flynn PM, Belzer M, Britto P, Hu C, Graham B, et al. Psychological factors, beliefs about medication, and adherence of youth with human immunodeficiency virus in a multisite directly observed therapy pilot study. J Adolesc Health. 2011;48(6):637–40.PubMedCentralPubMedCrossRef Garvie PA, Flynn PM, Belzer M, Britto P, Hu C, Graham B, et al. Psychological factors, beliefs about medication, and adherence of youth with human immunodeficiency virus in a multisite directly observed therapy pilot study. J Adolesc Health. 2011;48(6):637–40.PubMedCentralPubMedCrossRef
10.
Zurück zum Zitat Naar-King S, Parsons JT, Murphy DA, Chen XG, Harris DR, Belzer ME. Improving health outcomes for youth living with the human immunodeficiency virus a multisite randomized trial of a motivational intervention targeting multiple risk behaviors. Arch Pediatr Adolesc Med. 2009;163(12):1092–8.PubMedCentralPubMedCrossRef Naar-King S, Parsons JT, Murphy DA, Chen XG, Harris DR, Belzer ME. Improving health outcomes for youth living with the human immunodeficiency virus a multisite randomized trial of a motivational intervention targeting multiple risk behaviors. Arch Pediatr Adolesc Med. 2009;163(12):1092–8.PubMedCentralPubMedCrossRef
11.
Zurück zum Zitat Rotheram-Borus MJ, Swendeman D, Chovnick G. The past, present, and future of HIV prevention: integrating behavioral, biomedical, and structural intervention strategies for the next generation of HIV prevention. Annu Rev Clin Psychol. 2009;5:143–67.PubMedCentralPubMedCrossRef Rotheram-Borus MJ, Swendeman D, Chovnick G. The past, present, and future of HIV prevention: integrating behavioral, biomedical, and structural intervention strategies for the next generation of HIV prevention. Annu Rev Clin Psychol. 2009;5:143–67.PubMedCentralPubMedCrossRef
12.
Zurück zum Zitat Fjeldsoe BS, Marshall AL, Miller YD. Behavior change interventions delivered by mobile telephone short-message service. Am J Prev Med. 2009;36(2):165–73.PubMedCrossRef Fjeldsoe BS, Marshall AL, Miller YD. Behavior change interventions delivered by mobile telephone short-message service. Am J Prev Med. 2009;36(2):165–73.PubMedCrossRef
13.
14.
Zurück zum Zitat Dowshen N, Kuhns LM, Johnson A, Holoyda BJ, Garofalo R. Improving adherence to antiretroviral therapy for youth living with HIV/AIDS: a pilot study using personalized, interactive, daily text message reminders. J Med Internet Res. 2012;14(2):e51. doi:10.2196/jmir.2015. Dowshen N, Kuhns LM, Johnson A, Holoyda BJ, Garofalo R. Improving adherence to antiretroviral therapy for youth living with HIV/AIDS: a pilot study using personalized, interactive, daily text message reminders. J Med Internet Res. 2012;14(2):e51. doi:10.​2196/​jmir.​2015.
15.
Zurück zum Zitat Reynolds NR, Testa MA, Su M, Chesney MA, Neidig JL, Frank I, et al. Telephone support to improve antiretroviral medication adherence—a multisite, randomized controlled trial. Jaids-J Acquir Immuno Defic. 2008;47(1):62–8.CrossRef Reynolds NR, Testa MA, Su M, Chesney MA, Neidig JL, Frank I, et al. Telephone support to improve antiretroviral medication adherence—a multisite, randomized controlled trial. Jaids-J Acquir Immuno Defic. 2008;47(1):62–8.CrossRef
16.
Zurück zum Zitat Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838–45.PubMedCrossRef Lester RT, Ritvo P, Mills EJ, Kariri A, Karanja S, Chung MH, et al. Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial. Lancet. 2010;376(9755):1838–45.PubMedCrossRef
17.
Zurück zum Zitat Pop-Elrches C, Thirumurthy H, Habyarimana JP, et al. Mobile phone technologies improve adherence to antiretroviral treatment in resource-limited setting: a randomized controlled trial of text message reminders. AIDS Behav. 2011;25(6):825–34.CrossRef Pop-Elrches C, Thirumurthy H, Habyarimana JP, et al. Mobile phone technologies improve adherence to antiretroviral treatment in resource-limited setting: a randomized controlled trial of text message reminders. AIDS Behav. 2011;25(6):825–34.CrossRef
18.
Zurück zum Zitat Puccio JA, Belzer M, Olson J, Martinez M, Salata C, Tucker D, et al. The use of cell phone reminder calls for assisting HIV-infected adolescents and young adults to adhere to highly active antiretroviral therapy: a pilot study. Aids Patient Care and STDS. 2006;20(6):438–44.PubMedCrossRef Puccio JA, Belzer M, Olson J, Martinez M, Salata C, Tucker D, et al. The use of cell phone reminder calls for assisting HIV-infected adolescents and young adults to adhere to highly active antiretroviral therapy: a pilot study. Aids Patient Care and STDS. 2006;20(6):438–44.PubMedCrossRef
19.
Zurück zum Zitat Mallinson RK, Rajabiun S, Coleman S. The provider role in client engagement in HIV care. Aids Patient Care STDS. 2007;21:S77–84.PubMedCrossRef Mallinson RK, Rajabiun S, Coleman S. The provider role in client engagement in HIV care. Aids Patient Care STDS. 2007;21:S77–84.PubMedCrossRef
20.
Zurück zum Zitat Murphy DA, Marelich WD, Hoffman D, Steers WN. Predictors of antiretroviral adherence. Aids Care: Psychol Socio-Med Asp Aids/Hiv. 2004;16(4):471–84.CrossRef Murphy DA, Marelich WD, Hoffman D, Steers WN. Predictors of antiretroviral adherence. Aids Care: Psychol Socio-Med Asp Aids/Hiv. 2004;16(4):471–84.CrossRef
21.
Zurück zum Zitat Gardenier D, Andrews CM, Thomas DC, Bookhardt-Murray LJ, Fitzpatrick JJ. Social support and adherence: differences among clients in an AIDS day health care program. J Assoc Nurses AIDS Care. 2010;21(1):75–85.PubMedCrossRef Gardenier D, Andrews CM, Thomas DC, Bookhardt-Murray LJ, Fitzpatrick JJ. Social support and adherence: differences among clients in an AIDS day health care program. J Assoc Nurses AIDS Care. 2010;21(1):75–85.PubMedCrossRef
22.
Zurück zum Zitat Murphy DA, Marelich WD, Hoffman D, Steers WN. Predictors of antiretroviral adherence. AIDS Care. 2004;16(4):471–84.PubMedCrossRef Murphy DA, Marelich WD, Hoffman D, Steers WN. Predictors of antiretroviral adherence. AIDS Care. 2004;16(4):471–84.PubMedCrossRef
23.
Zurück zum Zitat Singh N, Berman SM, Swindells S, Justis JC, Mohr JA, Squier C, et al. Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy. Clin Infect Dis. 1999;29(4):824–30.PubMedCrossRef Singh N, Berman SM, Swindells S, Justis JC, Mohr JA, Squier C, et al. Adherence of human immunodeficiency virus-infected patients to antiretroviral therapy. Clin Infect Dis. 1999;29(4):824–30.PubMedCrossRef
24.
Zurück zum Zitat Mallinson RK, Rajabiun S, Coleman S. The provider role in client engagement in HIV care. AIDS Patient Care STDS. 2007;21(Suppl 1):S77–84.PubMed Mallinson RK, Rajabiun S, Coleman S. The provider role in client engagement in HIV care. AIDS Patient Care STDS. 2007;21(Suppl 1):S77–84.PubMed
25.
Zurück zum Zitat Diggle P, Liang K-Y, Zeger SL. Analysis of longitudinal data. Oxford: Clarendon Press; 1994. Diggle P, Liang K-Y, Zeger SL. Analysis of longitudinal data. Oxford: Clarendon Press; 1994.
26.
Zurück zum Zitat Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale: L. Erlbaum Associates; 1988. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale: L. Erlbaum Associates; 1988.
Metadaten
Titel
The Use of Cell Phone Support for Non-adherent HIV-Infected Youth and Young Adults: An Initial Randomized and Controlled Intervention Trial
verfasst von
Marvin E. Belzer
Sylvie Naar-King
Johanna Olson
Moussa Sarr
Sarah Thornton
Shoshana Y. Kahana
Aditya H. Gaur
Leslie F. Clark
The Adolescent Medicine Trials Network for HIV/AIDS Interventions
Publikationsdatum
01.04.2014
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 4/2014
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-013-0661-3

Weitere Artikel der Ausgabe 4/2014

AIDS and Behavior 4/2014 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.