Skip to main content
SpringerLink
Log in

IgE reactivity to Acarus siro extract in Korean dust mite allergic patients

  • Published:
Experimental and Applied Acarology Aims and scope Submit manuscript

Abstract

Although specific IgE to the storage mite Acarus siro is often detected, there are no detailed studies on IgE reactivity to A. siro in Korea. This study was undertaken to investigate the cross-reactivity to the mite species Dermatophagoides pteronyssinus, Dermatophagoides farinae, Tyrophagus putrescentiae, and A. siro in Korean mite allergic patients. Specific IgE values were determined for the four mite species and a competitive inhibition test was performed for mite extracts using the ImmunoCAP system. The IgE value to D. farinae was the highest among the four mite species tested. There was a strong correlation in the IgE value between house dust mites (D. pteronyssinus and D. farinae) and between storage mites (A. siro and T. putrescentiae). IgE reactivity to A. siro was inhibited by D. farinae and T. putrescentiae extract. Dermatophagoides farinae extract was the strongest inhibitor of IgE binding to A. siro extract, indicating that IgE reactivity to A. siro extract is a cross-reaction caused by sensitization to D. farinae. Strong IgE reactive components were observed in D. farinae and T. putrescentiae extract by SDS-PAGE and IgE immunoblotting. However, no strong IgE-binding component was observed for A. siro. Dermatophagoides farinae is the main source of mite allergens that cause sensitization in Korea. Serum IgE from some of the house dust mite-sensitized patients showed positive responses to storage mite allergens by cross-reaction. Therefore, it is necessary to pay special attention to the diagnosis of mite allergies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Arlian LG, Morgan MS, Vyszenski-Moher DL, Sharra D (2009) Cross-reactivity between storage and dust mites and between mites and shrimp. Exp App Acarol 47:159–172

    Article  Google Scholar 

  • Barber D, Arias J, Boquete M, Cardona V, Carrillo T, Gala G, Gamboa P, Garcia-Robaina JC, Hernandez D, Sanz ML, Tabar AI, Vidal C, Ipsen H, de la Torre F, Lombardero M (2012) Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. Clin Exp Allergy 42:1129–1138

    Article  PubMed  CAS  Google Scholar 

  • Blainey AD, Topping MD, Ollier S, Davies RJ (1989) Allergic respiratory disease in grain workers: the role of storage mites. J Allergy Clin Immunol 84:296–303

    Article  PubMed  CAS  Google Scholar 

  • Brazis P, Serra M, Selles A, Dethiouxt F, Biourge V, Puigdement A (2008) Evaluation of storage mite contamination of commercial dry dog food. Vet Dermatol 19:209–214

    Article  PubMed  Google Scholar 

  • Caraballo L, Acevedo N (2011) Allergy in the tropics: the impact of cross-reactivity between mites and ascaris. Front Biosci (Elite Ed) 3:51–64

    Article  Google Scholar 

  • Cuthbert OD, Brostoff J, Wraith DG, Brighton WD (1979) ‘Barn allergy’: asthma and rhinitis due to storage mites. Clin Allergy 9:229–236

    Article  PubMed  CAS  Google Scholar 

  • Dunn JA, Thind BB, Danks C, Chambers J (2008) Rapid method for the detection of storage mites in cereals: feasibility of an ELISA based approach. Bull Entomol Res 98:207–213

    Article  PubMed  CAS  Google Scholar 

  • Dutau G (2002) House dust mites; new food allergens. Revue Francaised’ Allergologieetd’ Immunologie Clinique 42:171–177

    Article  Google Scholar 

  • Eriksson TL, Whitley P, Johansson E, van Hage-Hamsten M, Gafvelin G (1999) Identification and characterization of two allergens from the dust mite Acarus siro, homologous with fatty acid-binding proteins. Int Arch Allergy Immunol 119:275–281

    Article  PubMed  CAS  Google Scholar 

  • Han CY, Bahn JM, Kim JG, Kim HS, Kim GC, Park GH, Gang CD, Cho JH (1999) The allergenicity of the storage mites (Tyrophagus putrescentiae and Acarus siro) in patients with allergic rhinitis. Korean J Otolaryngol 42:1392–1399

    Google Scholar 

  • Huang CH, Liew LM, Mah KW, Kuo IC, Lee BW, Chua KY (2006) Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase. Clin Exp Allergy 36:369–376

    Article  PubMed  CAS  Google Scholar 

  • Ingram CG, Symington IS, Jeffrey IG, Cuthbert OD (1979) Bronchial provocation studies in farmers allergic to storage mites. Lancet 2:1330–1332

    Article  PubMed  CAS  Google Scholar 

  • Jeong KY, Hong CS, Yong TS (2006a) Allergenic tropomyosins and their cross-reactivity. Protein Pept Lett 13:835–845

    Article  PubMed  CAS  Google Scholar 

  • Jeong KY, Lee IY, Lee J, Ree HI, Hong CS, Yong TS (2006b) Effectiveness of education for control of house dust mites and cockroaches in Seoul, Korea. Korean J Parasitol 44:73–79

    Article  PubMed Central  PubMed  Google Scholar 

  • Jeong KY, Lee H, Lee JS, Lee J, Lee IY, Ree HI, Hong CS, Yong TS (2007) Molecular cloning and the allergenic characterization of tropomyosin from Tyrophagus putrescentiae. Protein Pept Lett 14:431–436

    Article  PubMed  CAS  Google Scholar 

  • Jeong KY, Choi SY, Lee JH, Lee IY, Yong TS, Lee JS, Hong CS, Park JW (2012a) Standardization of house dust mite extracts in Korea. Allergy Asthma Immunol Res 4:346–350

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Jeong KY, Park JW, Hong CS (2012b) House dust mite allergy in Korea: the most important inhalant allergen in current and future. Allergy Asthma Immunol Res 4:313–325

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Lee WK, Choi WY (1980) Studies on the mites (Order Acarina) in Korea: I. Suborder sacroptiformes. Kisaengchunghak Chapchi 18:119–144

    PubMed  Google Scholar 

  • Melnyk JP, Scott-Dupree A, Marcone MF, Hill A (2010) Identification of cheese mite species inoculated on Mimolette and Milbenkase cheese through cryogenic scanning electron microscopy. J Dairy Sci 93:3461–3468

    Article  PubMed  CAS  Google Scholar 

  • Molina C, Aiache JM, Tourreau A, Jeanneret A (1975) Enqueteepidemiologique et immunologique chez les fromagers. Revue Francaised’ Allergologieetd’ Immunologie Clinique 15:89–91

    Article  Google Scholar 

  • Ownby DR, Bailey J (1986) Comparison of MAST with radioallergosorbent and skin tests for diagnosis of allergy in children. Am J Dis Child 140:45–48

    PubMed  CAS  Google Scholar 

  • Park JW, Ko SH, Yong TS, Ree HI, Jeoung BJ, Hong CS (1999) Cross-reactivity of Tyrophagus putrescentiae with Dermatophagoides farinae and Dermatophagoides pteronyssinus in urban areas. Ann Allergy Asthma Immunol 83:533–539

    Article  PubMed  CAS  Google Scholar 

  • Parsons AC (1924) Report on bakers’ dermatitis. Br J Dermatol Syphilis 36:193–200

    Article  Google Scholar 

  • Pytelkova J, Lepsik M, Sanda M, Talacko P, Maresova L, Mares M (2012) Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro. BMC Biochem 13:3

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Ree HI, Jeon SH, Lee IY, Hong CS, Lee DK (1997) Fauna and geographical distribution of house dust mites in Korea. Korean J Parasitol 35:9–17

    Article  PubMed  CAS  Google Scholar 

  • Revsbech P, Dueholm M (1990) Storage mite allergy among bakers. Allergy 45:204–208

    Article  PubMed  CAS  Google Scholar 

  • Van der Heide S, Niemeijer NR, Hovenga H, de Monchy JG, Dubois AE, Kauffman HF (1998) Prevalence of sensitization to the storage mites Acarus siro, Tyrophagus putrescentiae, and Lepidoglyphus destructor in allergic patients with different degrees of sensitization to the house-dust mite Dermatophagoides pteronyssinus. Allergy 53:426–430

    Article  PubMed  Google Scholar 

  • Zheng YW, Chen S, Lai XX, Gjesing B, Zhong NS, Spangfor MD (2012) Indoor mite allergen levels, specific IgE prevalence and IgE cross-inhibition pattern among asthmatic children in Haikou, southern China. Chin Med J 125:3059–3063

    PubMed  CAS  Google Scholar 

Download references

Acknowledgments

This work was supported by a Grant (No. C0010179) from the Business for Cooperative R&D between Industry, Academy, and Research Institute funded by the Korea Small and Medium Business Administration in 2012.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Institute of Allergy, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Mina Son, Kyoung Yong Jeong, Jae-Hyun Lee & Jung-Won Park

  2. ProteomeTech Inc., Seoul, 120-110, Korea

    Bum Joon Kim & Kook-Jin Lim

Authors
  1. Mina Son
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kyoung Yong Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Bum Joon Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kook-Jin Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jae-Hyun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jung-Won Park
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kyoung Yong Jeong.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Son, M., Jeong, K.Y., Kim, B.J. et al. IgE reactivity to Acarus siro extract in Korean dust mite allergic patients. Exp Appl Acarol 63, 57–64 (2014). https://doi.org/10.1007/s10493-013-9759-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10493-013-9759-6

Keywords

Search

Navigation