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Characteristics of bone marrow cells under conditions of impaired innervation in patients with spinal trauma

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Abstract

We studied quantitative and functional parameters of bone marrow stem cells and mature lymphocyte population under conditions of impaired innervation in patients with injuries to the cervical and thoracic portions of the spinal cord. Our findings indicated the absence of deficiency of quantitative and proliferative potentials of stem cells and demonstrated intact subpopulation structure of mature lymphocytes and T-cell proliferative activity similar to that in donors. The content of CD34+ cells in patients did not differ from that in donors. The percentage of CD34+CD38− hemopoietic stem cells was elevated in patients, presumably due to increased proliferative activity of hemopoietic stem cells. The possibility of derivation and in vitro culturing of fibroblast-like cells with mesenchymal stem cell phenotype was demonstrated.

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References

  1. Y. Akiyama, C. Radtke, and J. D. Kocsis, J. Neurosci., 22, 6623–6630 (2002).

    CAS  PubMed  Google Scholar 

  2. M. Artico, S. Bosco, C. Cavallotti, et al., Int. J. Mol. Med., 10, 77–80 (2002).

    CAS  PubMed  Google Scholar 

  3. F. Burke, M. S. Naylor, B. Davies, and F. Balkwill, Immunol. Today, 14, 165–170 (1993).

    Article  CAS  PubMed  Google Scholar 

  4. M. Chopp, X. H. Zhang, Y. Li, et al., Neuroreport, 11, No. 13, 3001–3005 (2000).

    CAS  PubMed  Google Scholar 

  5. E. L. Herzog, L. Chai, and D. S. Krause, Blood, 102, 3483–3493 (2003).

    Article  CAS  PubMed  Google Scholar 

  6. C. P. Hofstetter, E. J. Schwarz, D. Hess, et al., Proc. Natl. Acad. Sci. USA, 99, No. 4, 2199–2204 (2002).

    Article  CAS  PubMed  Google Scholar 

  7. P. O. Iversen, N. Hjeltnes, B. Holm, et al., Blood, 96, 2081–2083 (2000).

    CAS  PubMed  Google Scholar 

  8. W. F. Kliesch, J. M. Cruse, R. E. Lewis, et al., Paraplegia, 34, No. 4, 82–90 (1996).

    CAS  PubMed  Google Scholar 

  9. G. J. Maestroni, Blood, 92, 2971–2973 (1998).

    CAS  PubMed  Google Scholar 

  10. G. J. Maestroni, Ann. NY Acad. Sci., 917, 29–37 (2000).

    CAS  PubMed  Google Scholar 

  11. E. Mezey, K. J. Chandross, G. Harta, et al., Science, 290, 1779–1782 (2000).

    Article  CAS  PubMed  Google Scholar 

  12. U. Steidl, S. Bork, S. Schaub, et al., Blood, 104, 81–88 (2004).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Russia

    E. R. Chernykh, E. Ya. Shevela, O. Yu. Leplina, M. A. Tikhonova, A. A. Ostanin, A. D. Kulagin, N. V. Pronkina & V. A. Kozlov

  2. Institute of Traumatology and Orthopedics, Ministry of Health of the Russian Federation, Novosibirsk

    Zh. M. Muradov & V. V. Stupak

Authors
  1. E. R. Chernykh
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  2. E. Ya. Shevela
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  3. O. Yu. Leplina
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  4. M. A. Tikhonova
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  5. A. A. Ostanin
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  6. A. D. Kulagin
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  7. N. V. Pronkina
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  8. Zh. M. Muradov
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  9. V. V. Stupak
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  10. V. A. Kozlov
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Corresponding author

Correspondence to E. R. Chernykh.

Additional information

__________

Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 8–11, January, 2006

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Chernykh, E.R., Shevela, E.Y., Leplina, O.Y. et al. Characteristics of bone marrow cells under conditions of impaired innervation in patients with spinal trauma. Bull Exp Biol Med 141, 117–120 (2006). https://doi.org/10.1007/s10517-006-0109-0

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  • DOI: https://doi.org/10.1007/s10517-006-0109-0

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