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Polymorphic Variants of Extracellular Superoxide Dismutase Gene in a Romanian Population with Atheroma

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Abstract

Extracellular superoxide dismutase (EC-SOD) is the main SOD isoform in the arterial wall contributing to cardiovascular defense against oxidative stress by removing the superoxide anion. In our study, the Thr40Ala and Arg213Gly polymorphic variants of the EC-SOD gene (SOD 3 ) were investigated for associations with atherosclerosis and other related factors in 144 subjects with significant atheroma (having one, two, or three major coronary arteries with >50% obstruction, and/or peripheral artery lesions, and/or carotid artery stenosis demonstrated by angiography and echography) and in 150 subjects with no significant atheroma. For the Arg213Gly polymorphism, only five heterozygous subjects were found. Although the difference in the genotype distribution for the Thr40Ala polymorphism was not statistically significant between patients with atheroma (AA 49.3%, AG 34.7%, GG 16.0%) and those without significant atheroma (AA 41.3%, AG 43.3%, GG 15.3%), there was an association of the Thr40 allele with diabetes (P = 0.03) and hypertension (P = 0.04).

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Acknowledgment

This study was supported by Marie Curie Host Fellowships, contract number HPMT-CT-2001-00320, University of Leeds, UK.

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Authors and Affiliations

  1. Biochemistry Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania

    Olguta C. Samoila, Andrei Anghel, Liviu Tamas & Edward Seclaman

  2. Academic Unit of Molecular Vascular Medicine, Light Laboratories, University of Leeds, Leeds, UK

    Angela M. Carter & Simon T. Futers

  3. Medical Polyclinics Department, University of Medicine and Pharmacy “Victor Babes”, Timisoara, Romania

    Gabriela Otiman

Authors
  1. Olguta C. Samoila
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  2. Angela M. Carter
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  3. Simon T. Futers
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  4. Gabriela Otiman
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  5. Andrei Anghel
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  6. Liviu Tamas
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  7. Edward Seclaman
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Correspondence to Olguta C. Samoila.

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Samoila, O.C., Carter, A.M., Futers, S.T. et al. Polymorphic Variants of Extracellular Superoxide Dismutase Gene in a Romanian Population with Atheroma. Biochem Genet 46, 634–643 (2008). https://doi.org/10.1007/s10528-008-9177-3

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  • DOI: https://doi.org/10.1007/s10528-008-9177-3

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