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Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity

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Abstract

Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose tissue. This protein acts on the hypothalamic regions of the brain which control eating behavior, thus playing a significant role in maintaining body’s metabolism. Leptin receptors belong to glycoprotein 130 (gp130) family of cytokine receptors and exist in six isoforms (LEPR a–f), and all the isoforms are encoded by LEPR gene; out of these isoforms, the LEPR-b receptor is the ‘longest form,’ and in most of the cases, mutations in this isoform cause severe obesity. Also, mutations in the leptin gene (LEP) or its receptors gene can lead to obesity. Some biochemical pathways affect the bioactivity of leptin and/or its receptors. To date, eleven pathogenic mutations have been reported in the LEP which are p.L72S, p.N103K, p.R105W, p.H118L, p.S141C, p.W121X c.104_106delTCA, c.135del3bp, c.398delG, c.481_482delCT, and c.163C>T. Different mutations in the LEPR have also been reported as c.2396-1 G>T, c.1675 G>A, p.P316T, etc. In some studies, where leptin was deficient, leptin replacement therapy has shown positive impact by preventing weight gain and obesity.

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References

  • Ahima RS, Qi Y, Singhal NS, Jackson MB, Scherer PE (2006) Brain adipocytokine action and metabolic regulation. Diabetes 55(Suppl 2):S145–S154

    Article  CAS  PubMed  Google Scholar 

  • Bluher S, Mantzoros CS (2009) Leptin in humans: lessons from translational research. Am J Clin Nutr 89(3):991S–997S

    Article  PubMed  PubMed Central  Google Scholar 

  • Chekhranova MK, Karpova SK, Iatsyshina SB, Pankov Iu A (2008) A new mutation c.422C>G (p. S141C) in homo- and heterozygous forms of the human leptin gene. Bioorg Khim 34(6):854–856

    CAS  PubMed  Google Scholar 

  • Chen K, Li FH, Li J, Cai HB, Strom S, Bisello A, Kelley DE, Friedman-Einat M, Skibinski GA, McCrory MA, Szalai AJ, Zhao AZ (2006) Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 12(4):425–432

    Article  CAS  PubMed  Google Scholar 

  • Cottrell EC, Mercer JG (2012) Leptin receptors. Handb Exp Pharmacol (209):3–21. doi:10.1007/978-3-642-24716-3_1

  • Dubern B, Clement K (2012) Leptin and leptin receptor-related monogenic obesity. Biochimie 94(10):2111–2115

    Article  CAS  PubMed  Google Scholar 

  • Farooqi IS (2005) Genetic and hereditary aspects of childhood obesity. Best Pract Res Clin Endocrinol Metab 19(3):359–374

    Article  CAS  PubMed  Google Scholar 

  • Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O’Rahilly S (2002) Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency. J Clin Invest 110(8):1093–1103

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Farooqi IS, Wangensteen T, Collins S, Kimber W, Matarese G, Keogh JM, Lank E, Bottomley B, Lopez-Fernandez J, Ferraz-Amaro I, Dattani MT, Ercan O, Myhre AG, Retterstol L, Stanhope R, Edge JA, McKenzie S, Lessan N, Ghodsi M, De Rosa V, Perna F, Fontana S, Barroso I, Undlien DE, O’Rahilly S (2007) Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor. N Engl J Med 356(3):237–247

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Farr OM, Fiorenza C, Papageorgiou P, Brinkoetter M, Ziemke F, Koo BB, Rojas R, Mantzoros CS (2014) Leptin therapy alters appetite and neural responses to food stimuli in brain areas of leptin-sensitive subjects without altering brain structure. J Clin Endocrinol Metab 99(12):E2529–E2538

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fatima W, Shahid A, Imran M, Manzoor J, Hasnain S, Rana S, Mahmood S (2011) Leptin deficiency and leptin gene mutations in obese children from Pakistan. Int J Pediatr Obes 6(5–6):419–427

    Article  PubMed  Google Scholar 

  • Fischer-Posovszky P, von Schnurbein J, Moepps B, Lahr G, Strauss G, Barth TF, Kassubek J, Muhleder H, Moller P, Debatin KM, Gierschik P, Wabitsch M (2010) A new missense mutation in the leptin gene causes mild obesity and hypogonadism without affecting T cell responsiveness. J Clin Endocrinol Metab 95(6):2836–2840

    Article  CAS  PubMed  Google Scholar 

  • Frank S, Heni M, Moss A, von Schnurbein J, Farooqi S, Haring HU, Fritsche A, Preissl H, Wabitsch M (2013) Long-term stabilization effects of leptin on brain functions in a leptin-deficient patient. PLoS One 8(6):e65893

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Friedman JM (2010) A tale of two hormones. Nat Med 16(10):1100–1106

    Article  CAS  PubMed  Google Scholar 

  • Funcke JB, von Schnurbein J, Lennerz B, Lahr G, Debatin KM, Fischer-Posovszky P, Wabitsch M (2014) Monogenic forms of childhood obesity due to mutations in the leptin gene. Mol Cell Pediatr 1(1):3

    Article  PubMed  PubMed Central  Google Scholar 

  • Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O’Rahilly S, Trussell RA (2004) Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to 4 years of leptin therapy. J Clin Endocrinol Metab 89(10):4821–4826

    Article  CAS  PubMed  Google Scholar 

  • Hannema SE, Wit JM, Houdijk ME, van Haeringen A, Bik EC, Verkerk AJ, Uitterlinden AG, Kant SG, Oostdijk W, Bakker E, Delemarre-van de Waal HA, Losekoot M (2016) Novel leptin receptor mutations identified in two girls with severe obesity are associated with increased bone mineral density. Horm Res Paediatr. doi:10.1159/000444055

    Google Scholar 

  • Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M, Yoshimasa Y, Nishi S et al (1995) Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 270(46):27728–27733

    Article  CAS  PubMed  Google Scholar 

  • Kalra SP (2007) Global life-long health benefits of repression of hypothalamic NPY system by central leptin gene therapy. Curr Top Med Chem 7(17):1675–1681

    Article  CAS  PubMed  Google Scholar 

  • Khan AR, Awan FR (2016) Leptin resistance: a possible interface between obesity and pulmonary-related disorders. Int J Endocrinol Metab 14(1):e32586

    Google Scholar 

  • Khan AR, Awan FR, Najam SS, Islam M, Siddique T, Zain M (2015) Elevated serum level of human alkaline phosphatase in obesity. J Pak Med Assoc 65(11):1182–1185

    PubMed  Google Scholar 

  • Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379(6566):632–635

    Article  CAS  PubMed  Google Scholar 

  • Leung A, Trac C, Du J, Natarajan R, Schones DE (2016) Persistent chromatin modifications induced by high fat diet. J Biol Chem 291(20):10446–10455. doi:10.1074/jbc.M115.711028

    Article  CAS  PubMed  Google Scholar 

  • Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O’Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S, Krauss RM, Veldhuis JD, Wagner AJ, DePaoli AM, McCann SM, Wong ML (2004) Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci USA 101(13):4531–4536

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S, Buchkovich ML, Yang J, Croteau-Chonka DC, Esko T, Fall T, Ferreira T, Gustafsson S, Kutalik Z, Luan J, Magi R, Randall JC, Winkler TW, Wood AR, Workalemahu T, Faul JD, Smith JA, Hua Zhao J, Zhao W, Chen J, Fehrmann R, Hedman AK, Karjalainen J, Schmidt EM, Absher D, Amin N, Anderson D, Beekman M, Bolton JL, Bragg-Gresham JL, Buyske S, Demirkan A, Deng G, Ehret GB, Feenstra B, Feitosa MF, Fischer K, Goel A, Gong J, Jackson AU, Kanoni S, Kleber ME, Kristiansson K, Lim U, Lotay V, Mangino M, Mateo Leach I, Medina-Gomez C, Medland SE, Nalls MA, Palmer CD, Pasko D, Pechlivanis S, Peters MJ, Prokopenko I, Shungin D, Stancakova A, Strawbridge RJ, Ju Sung Y, Tanaka T, Teumer A, Trompet S, van der Laan SW, van Setten J, Van Vliet-Ostaptchouk JV, Wang Z, Yengo L, Zhang W, Isaacs A, Albrecht E, Arnlov J, Arscott GM, Attwood AP, Bandinelli S, Barrett A, Bas IN, Bellis C, Bennett AJ, Berne C, Blagieva R, Bluher M, Bohringer S, Bonnycastle LL, Bottcher Y, Boyd HA, Bruinenberg M, Caspersen IH, Ida Chen YD, Clarke R, Daw EW, de Craen AJ, Delgado G, Dimitriou M, Doney AS, Eklund N, Estrada K, Eury E, Folkersen L, Fraser RM, Garcia ME, Geller F, Giedraitis V, Gigante B, Go AS, Golay A, Goodall AH, Gordon SD, Gorski M, Grabe HJ, Grallert H, Grammer TB, Grassler J, Gronberg H, Groves CJ, Gusto G, Haessler J, Hall P, Haller T, Hallmans G, Hartman CA, Hassinen M, Hayward C, Heard-Costa NL, Helmer Q, Hengstenberg C, Holmen O, Hottenga JJ, James AL, Jeff JM, Johansson A, Jolley J, Juliusdottir T, Kinnunen L, Koenig W, Koskenvuo M, Kratzer W, Laitinen J, Lamina C, Leander K, Lee NR, Lichtner P, Lind L, Lindstrom J, Sin Lo K, Lobbens S, Lorbeer R, Lu Y, Mach F, Magnusson PK, Mahajan A, McArdle WL, McLachlan S, Menni C, Merger S, Mihailov E, Milani L, Moayyeri A, Monda KL, Morken MA, Mulas A, Muller G, Muller-Nurasyid M, Musk AW, Nagaraja R, Nothen MM, Nolte IM, Pilz S, Rayner NW, Renstrom F, Rettig R, Ried JS, Ripke S, Robertson NR, Rose LM, Sanna S, Scharnagl H, Scholtens S, Schumacher FR, Scott WR, Seufferlein T, Shi J, Vernon Smith A, Smolonska J, Stanton AV, Steinthorsdottir V, Stirrups K, Stringham HM, Sundstrom J, Swertz MA, Swift AJ, Syvanen AC, Tan ST, Tayo BO, Thorand B, Thorleifsson G, Tyrer JP, Uh HW, Vandenput L, Verhulst FC, Vermeulen SH, Verweij N, Vonk JM, Waite LL, Warren HR, Waterworth D, Weedon MN, Wilkens LR, Willenborg C, Wilsgaard T, Wojczynski MK, Wong A, Wright AF, Zhang Q, LifeLines Cohort S, Brennan EP, Choi M, Dastani Z, Drong AW, Eriksson P, Franco-Cereceda A, Gadin JR, Gharavi AG, Goddard ME, Handsaker RE, Huang J, Karpe F, Kathiresan S, Keildson S, Kiryluk K, Kubo M, Lee JY, Liang L, Lifton RP, Ma B, McCarroll SA, McKnight AJ, Min JL, Moffatt MF, Montgomery GW, Murabito JM, Nicholson G, Nyholt DR, Okada Y, Perry JR, Dorajoo R, Reinmaa E, Salem RM, Sandholm N, Scott RA, Stolk L, Takahashi A, Tanaka T, Van’t Hooft FM, Vinkhuyzen AA, Westra HJ, Zheng W, Zondervan KT, Consortium AD, Group A-BW, Consortium CAD, Consortium CK, Glgc, Icbp, Investigators M, Mu TC, Consortium MI, Consortium P, ReproGen C, Consortium G, International Endogene C, Heath AC, Arveiler D, Bakker SJ, Beilby J, Bergman RN, Blangero J, Bovet P, Campbell H, Caulfield MJ, Cesana G, Chakravarti A, Chasman DI, Chines PS, Collins FS, Crawford DC, Cupples LA, Cusi D, Danesh J, de Faire U, den Ruijter HM, Dominiczak AF, Erbel R, Erdmann J, Eriksson JG, Farrall M, Felix SB, Ferrannini E, Ferrieres J, Ford I, Forouhi NG, Forrester T, Franco OH, Gansevoort RT, Gejman PV, Gieger C, Gottesman O, Gudnason V, Gyllensten U, Hall AS, Harris TB, Hattersley AT, Hicks AA, Hindorff LA, Hingorani AD, Hofman A, Homuth G, Hovingh GK, Humphries SE, Hunt SC, Hypponen E, Illig T, Jacobs KB, Jarvelin MR, Jockel KH, Johansen B, Jousilahti P, Jukema JW, Jula AM, Kaprio J, Kastelein JJ, Keinanen-Kiukaanniemi SM, Kiemeney LA, Knekt P, Kooner JS, Kooperberg C, Kovacs P, Kraja AT, Kumari M, Kuusisto J, Lakka TA, Langenberg C, Le Marchand L, Lehtimaki T, Lyssenko V, Mannisto S, Marette A, Matise TC, McKenzie CA, McKnight B, Moll FL, Morris AD, Morris AP, Murray JC, Nelis M, Ohlsson C, Oldehinkel AJ, Ong KK, Madden PA, Pasterkamp G, Peden JF, Peters A, Postma DS, Pramstaller PP, Price JF, Qi L, Raitakari OT, Rankinen T, Rao DC, Rice TK, Ridker PM, Rioux JD, Ritchie MD, Rudan I, Salomaa V, Samani NJ, Saramies J, Sarzynski MA, Schunkert H, Schwarz PE, Sever P, Shuldiner AR, Sinisalo J, Stolk RP, Strauch K, Tonjes A, Tregouet DA, Tremblay A, Tremoli E, Virtamo J, Vohl MC, Volker U, Waeber G, Willemsen G, Witteman JC, Zillikens MC, Adair LS, Amouyel P, Asselbergs FW, Assimes TL, Bochud M, Boehm BO, Boerwinkle E, Bornstein SR, Bottinger EP, Bouchard C, Cauchi S, Chambers JC, Chanock SJ, Cooper RS, de Bakker PI, Dedoussis G, Ferrucci L, Franks PW, Froguel P, Groop LC, Haiman CA, Hamsten A, Hui J, Hunter DJ, Hveem K, Kaplan RC, Kivimaki M, Kuh D, Laakso M, Liu Y, Martin NG, Marz W, Melbye M, Metspalu A, Moebus S, Munroe PB, Njolstad I, Oostra BA, Palmer CN, Pedersen NL, Perola M, Perusse L, Peters U, Power C, Quertermous T, Rauramaa R, Rivadeneira F, Saaristo TE, Saleheen D, Sattar N, Schadt EE, Schlessinger D, Slagboom PE, Snieder H, Spector TD, Thorsteinsdottir U, Stumvoll M, Tuomilehto J, Uitterlinden AG, Uusitupa M, van der Harst P, Walker M, Wallaschofski H, Wareham NJ, Watkins H, Weir DR, Wichmann HE, Wilson JF, Zanen P, Borecki IB, Deloukas P, Fox CS, Heid IM, O’Connell JR, Strachan DP, Stefansson K, van Duijn CM, Abecasis GR, Franke L, Frayling TM, McCarthy MI, Visscher PM, Scherag A, Willer CJ, Boehnke M, Mohlke KL, Lindgren CM, Beckmann JS, Barroso I, North KE, Ingelsson E, Hirschhorn JN, Loos RJ, Speliotes EK (2015) Genetic studies of body mass index yield new insights for obesity biology. Nature 518(7538):197–206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY (2013) Imbalance between neutrophil elastase and its inhibitor alpha 1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab 17(4):534–548

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mazen I, El-Gammal M, Abdel-Hamid M, Amr K (2009) A novel homozygous missense mutation of the leptin gene (N103 K) in an obese Egyptian patient. Mol Genet Metab 97(4):305–308

    Article  CAS  PubMed  Google Scholar 

  • Mazen I, El-Gammal M, Abdel-Hamid M, Farooqi IS, Amr K (2011) Homozygosity for a novel missense mutation in the leptin receptor gene (P316T) in two Egyptian cousins with severe early onset obesity. Mol Genet Metab 102(4):461–464

    Article  CAS  PubMed  Google Scholar 

  • Mazen I, Amr K, Tantawy S, Farooqi IS, Gammal ME (2014) A novel mutation in the leptin gene (W121X) in an Egyptian family. Mol Gen Metab 1:474–476

    CAS  Google Scholar 

  • Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O’Rahilly S (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387(6636):903–908

    Article  CAS  PubMed  Google Scholar 

  • Pasco JA, Henry MJ, Kotowicz MA, Collier GR, Ball MJ, Ugoni AM, Nicholson GC (2001) Serum leptin levels are associated with bone mass in nonobese women. J Clin Endocrinol Metab 86(5):1884–1887

    CAS  PubMed  Google Scholar 

  • Paz-Filho G, Mastronardi C, Delibasi T, Wong ML, Licinio J (2010) Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy. Arq Bras Endocrinol Metabol 54(8):690–697

    Article  PubMed  PubMed Central  Google Scholar 

  • Paz-Filho G, Wong ML, Licinio J (2011) Ten years of leptin replacement therapy. Obes Rev 12(5):e315–e323

    Article  CAS  PubMed  Google Scholar 

  • Ronti T, Lupattelli G, Mannarino E (2006) The endocrine function of adipose tissue: an update. Clin Endocrinol (Oxf) 64(4):355–365

    CAS  Google Scholar 

  • Saeed S, Bech PR, Hafeez T, Alam R, Falchi M, Ghatei MA, Bloom SR, Arslan M, Froguel P (2014a) Changes in levels of peripheral hormones controlling appetite are inconsistent with hyperphagia in leptin-deficient subjects. Endocrine 45(3):401–408

    Article  CAS  PubMed  Google Scholar 

  • Saeed S, Bonnefond A, Manzoor J, Philippe J, Durand E, Arshad M, Sand O, Butt TA, Falchi M, Arslan M, Froguel P (2014b) Novel LEPR mutations in obese Pakistani children identified by PCR-based enrichment and next generation sequencing. Obesity (Silver Spring) 22(4):1112–1117

    Article  CAS  Google Scholar 

  • Saeed S, Butt TA, Anwer M, Arslan M, Froguel P (2012) High prevalence of leptin and melanocortin-4 receptor gene mutations in children with severe obesity from Pakistani consanguineous families. Mol Genet Metab 106(1):121–126

    Article  CAS  PubMed  Google Scholar 

  • Shore SA (2010) Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol 108(3):735–743

    Article  PubMed  Google Scholar 

  • Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD (1998) A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 18(3):213–215

    Article  CAS  PubMed  Google Scholar 

  • Thakur S, Kumar A, Dubey S, Saxena R, Peters AN, Singhal A (2014) A novel mutation of the leptin gene in an Indian patient. Clin Genet 86(4):391–393

    Article  CAS  PubMed  Google Scholar 

  • Wabitsch M, Funcke JB, von Schnurbein J, Denzer F, Lahr G, Mazen I, El-Gammal M, Denzer C, Moss A, Debatin KM, Gierschik P, Mistry V, Keogh JM, Farooqi IS, Moepps B, Fischer-Posovszky P (2015) Severe early-onset obesity due to bioinactive leptin caused by a p. N103K mutation in the leptin gene. J Clin Endocrinol Metab 100(9):3227–3230

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wasim M, Fakhar N (2015) Carrier frequency of congenital leptin deficiency in central Punjab region of Pakistan. J Obes Weight Loss Ther 5:260. doi:10.4172/2165-7904.1000260

    Google Scholar 

  • Xue J, Ideraabdullah FY (2016) An assessment of molecular pathways of obesity susceptible to nutrient, toxicant and genetically induced epigenetic perturbation. J Nutr Biochem 30:1–13

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372(6505):425–432

    Article  CAS  PubMed  Google Scholar 

  • Zhao Y, Hong N, Liu X, Wu B, Tang S, Yang J, Hu C, Jia W (2014) A novel mutation in leptin gene is associated with severe obesity in Chinese individuals. Biomed Res Int 2014:912052

    PubMed  PubMed Central  Google Scholar 

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  1. Diabetes and Cardio-Metabolic Disorders Laboratory, Health Biotechnology Division, National Institute for Biotechnology and Genetic Engineering (NIBGE), Faisalabad, Pakistan

    Muhammad Wasim, Fazli Rabbi Awan, Syeda Sadia Najam & Haq Nawaz Khan

  2. Obesity and Diabetes Research Laboratory, Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan

    Abdul Rehman Khan

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  1. Muhammad Wasim
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Wasim, M., Awan, F.R., Najam, S.S. et al. Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity. Biochem Genet 54, 565–572 (2016). https://doi.org/10.1007/s10528-016-9751-z

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