Abstract
Objective
To investigate the roles of miR-34a in progression and chemoresistance of glioma cells.
Results
Quantitative real-time PCR analysis showed that miR-34a level was lower, but PD-L1 expression level was higher in glioma tissue specimens compared with normal brain tissues and their expression levels were negatively correlated. Ectopic expression of miR-34a inhibited glioma cell proliferation, promoted cell cycle arrest in G1/S phase and cell apoptosis. Additionally, miR-34a/PD-L1 axis was again confirmed and co-expression of PD-L1 with miR-34a mimics attenuated the effects of miR-34a on cell proliferation and apoptosis in glioma cells. Importantly, PD-L1 overexpression resulted in chemoresistance in glioma cells, this effect was attenuated by miR-34a overexpression.
Conclusions
miR-34a inhibits glioma cells progression and chemoresistance via targeting PD-L1.
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Change history
10 January 2023
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1007/s10529-023-03344-4
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Wang, Y., Wang, L. RETRACTED ARTICLE: miR-34a attenuates glioma cells progression and chemoresistance via targeting PD-L1. Biotechnol Lett 39, 1485–1492 (2017). https://doi.org/10.1007/s10529-017-2397-z
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DOI: https://doi.org/10.1007/s10529-017-2397-z