Abstract
Crystalline lithium phthalocyanine (LiPc) can be used to sense oxygen. To enhance biocompatibility/stability of LiPc, we encapsulated LiPc in Teflon AF (TAF), cellulose acetate (CA), and polyvinyl acetate (PVAc) (TAF, previously used to encapsulate LiPc, was a comparator). We identified water-miscible solvents that don’t dissolve LiPc crystals, but are solvents for the polymers, and encapsulated crystals by solvent evaporation. Oxygen sensitivity of films was characterized in vitro and in vivo. Encapsulation did not change LiPc oximetry properties in vitro at anoxic conditions or varying partial pressures of oxygen (pO2). EPR linewidth of encapsulated particles was linear with pO2, responding to pO2 changes quickly and reproducibly for dynamic measurements. Encapsulated LiPc was unaffected by biological oxidoreductants, stable in vivo for four weeks. Oximetry, stability and biocompatibility properties of LiPc films were comparable, but both CA and PVAc films are cheaper, and easier to fabricate and handle than TAF films, making them superior.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
C. Baudelet, B. Gallez, Magn. Reson. Imaging 22(7), 905–912 (2004)
A. Bratasz, R.P. Pandian, G. Ilangovan, P. Kuppusamy, Adv. Exp. Med. Biol. 578, 375–380 (2006) doi:10.1007/0-387-29540-2_58
A. Bratasz, R.P. Pandian, Y. Deng, S. Petryakov, J.C. Grecula, N. Gupta, P. Kuppusamy, Magn. Reson. Med. 57(5), 950–959 (2007) doi:10.1002/mrm.21212
M. Dinguizli, S. Jeumont, N. Beghein, J. He, T. Walczak, P.N. Lesniewski, H. Hou, O.Y. Grinberg, A. Sucheta, H.M. Swartz, B. Gallez, Biosens. Bioelectron. 21(7), 1015–1022 (2006) doi:10.1016/j.bios.2005.03.009
E. Entcheva, H. Bien, L. Yin, C.Y. Chung, M. Farrell, Y. Kostov, Biomaterials 25(26), 5753–5762 (2004) doi:10.1016/j.biomaterials.2004.01.024
H. Fujii, K. Itoh, R.P. Pandian, M. Sakata, P. Kuppusamy, H. Hirata, Magn. Reson. Med. Sci. 6(2), 83–89 (2007) doi:10.2463/mrms.6.83
B. Gallez, H.M. Swartz, NMR Biomed. 17(5), 223–225 (2004) doi:10.1002/nbm.913
B. Gallez, B.F. Jordan, C. Baudelet, Magn. Reson. Med. 42(1), 193–196 (1999) doi:10.1002/(SICI)1522-2594(199907)42:1<193::AID-MRM25>3.0.CO;2-C
O.Y. Grinberg, H. Hou, S.A. Grinberg, K.L. Moodie, E. Demidenko, B.J. Friedman, M.J. Post, H.M. Swartz, Physiol. Meas. 25(3), 659–670 (2004)
J. He, N. Beghein, P. Ceroke, R.B. Clarkson, H.M. Swartz, B. Gallez, Magn. Reson. Med. 46(3), 610–614 (2001) doi:10.1002/mrm.1234
G. Ilangovan, J.L. Zweier, P. Kuppusamy, J. Phys. Chem. B 104(40), 9404–9410 (2000a) doi:10.1021/jp0013863
G. Ilangovan, J.L. Zweier, P. Kuppusamy, J. Phys. Chem. B 104(17), 4047–4059 (2000b) doi:10.1021/jp9935182
G. Ilangovan, H. Li, J.L. Zweier, P. Kuppusamy, J. Phys. Chem. B 105(22), 5323–5330 (2001) doi:10.1021/jp010130
G. Ilangovan, A. Manivannan, H. Li, H. Yanagi, J.L. Zweier, P. Kuppusamy, Free Radic. Biol. Med. 32(2), 139–147 (2002a) doi:10.1016/S0891-5849(01)00784-5
G. Ilangovan, R. Pal, J.L. Zweier, P. Kuppusamy, J. Phys. Chem. B 106(46), 11929–11935 (2002b) doi:10.1021/jp026360l
G. Ilangovan, A. Bratasz, H. Li, P. Schmalbrock, J.L. Zweier, P. Kuppusamy, Magn. Reson. Med. 52(3), 650–657 (2004a) doi:10.1002/mrm.20188
G. Ilangovan, J.L. Zweier, P. Kuppusamy, J. Magn. Reson. 170(1), 42–48 (2004b) doi:10.1016/j.jmr.2004.05.018
H. Jiang, N. Beghei, R.B. Clarkson, H.M. Swartz, B. Gallez, Phys. Med. Biol. 46(12), 33239–33239 (2001)
R. Ke, Y. Xu, Z. Wang, S.U. Khan, Environ. Sci. Technol. 40(12), 3906–3911 (2006) doi:10.1021/es060493t
A.C. Kulkarni, P. Kuppusamy, N. Parinandi, Antioxid. Redox Signal. 9(10), 1717–1730 (2007) doi:10.1089/ars.2007.1724
F.C. Kung, M.C. Yang, Colloids Surf. B Biointerfaces 47(1), 36–42 (2006) doi:10.1016/j.colsurfb.2005.11.019
V.K. Kutala, N.L. Parinandi, R.P. Pandian, P. Kuppusamy, Antioxid. Redox Signal. 6(3), 597–603 (2004) doi:10.1089/152308604773934350
V.K. Kutala, M. Khan, M.G. Angelos, P. Kuppusamy, Antioxid. Redox Signal. 9(8), 1193–1206 (2007) doi:10.1089/ars.2007.1636
M. Lan, N. Beghein, N. Charlier, B. Gallez, Magn. Reson. Med. 51(6), 1272–1278 (2004) doi:10.1002/mrm.20077
X.Z. Liang, Y. Zhang, C.E. Lunte, J. Pharm. Biomed. Anal. 16(7), 1143–1152 (1998) doi:10.1016/S0731-7085(97)00204-5
K.J. Liu, P. Gast, M. Moussavi, S.W. Norby, N. Vahidi, T. Walczak, M. Wu, H.M. Swartz, Proc. Natl. Acad. Sci. USA 90(12), 5438–5442 (1993) doi:10.1073/pnas.90.12.5438
K. Masumoto, S.-i. Takasugi, N. Hotta, K. Fujishima, Y. Iwamoto, Eur. J. Appl. Physiol. 94(1–2), 54–61 (2005)
T.C. Merkel, V. Bondar, K. Nagai, B.D. Freeman, Y.P. Yampolskii, Macromol. 32, 8427–8440 (1999) doi:10.1021/ma990685r
F. Mottu, P. Gailloud, D. Massuelle, D.A. Rufenacht, E. Doelker, Biomaterials 21(8), 803–811 (2000) doi:10.1016/S0142-9612(99)00243-4
G.G. Novoa, J. Heinämäki, M. Sabir, A. Osmo, I.C. Antonio, S.P. Alberto, J. Yliruusi, Eur. J. Pharm. Biopharm. 59, 343–350 (2005) doi:10.1016/j.ejpb.2004.07.012
R.P. Pandian, V.K. Kutala, N.L. Parinandi, J.L. Zweier, P. Kuppusamy, Arch. Biochem. Biophys. 420(1), 169–175 (2003a) doi:10.1016/j.abb.2003.09.008
R.P. Pandian, N.L. Parinandi, G. Ilangovan, J.L. Zweier, P. Kuppusamy, Free Radic. Biol. Med. 35(9), 1138–1148 (2003b) doi:10.1016/S0891-5849(03)00496-9
R.P. Pandian, V.K. Kutala, A. Liaugminas, N.L. Parinandi, P. Kuppusamy, Mol. Cell. Biochem. 278(1–2), 119–127 (2005) doi:10.1007/s11010-005-6936-x
R.P. Pandian, V. Dang, P.T. Manoharan, J.L. Zweier, P. Kuppusamy, J. Magn. Reson. 181(1), 154–161 (2006a) doi:10.1016/j.jmr.2006.04.004
R.P. Pandian, Y. Kim, P.M. Woodward, J.M. Zweier, P.T. Manoharan, P. Kuppusamy, J. Mater. Chem. 16(36), 3609–3618 (2006b) doi:10.1039/b517976a
R.P. Pandian, M. Dolgos, V. Dang, J.Z. Sostaric, P.M. Woodward, P. Kuppusamy, Chem. Mater. 19(14), 3545–3552 (2007) doi:10.1021/cm070622k
D.L. Pole, J. Pharm. Sci. 97(3), 1071–1088 (2008) doi:10.1002/jps.21060
J.Z. Sostaric, R.P. Pandian, L.K. Weavers, P. Kuppusamy, Chem. Mater. 18(17), 4183–4189 (2006) doi:10.1021/cm060751l
R. Springett, H.M. Swartz, Antioxid. Redox Signal. 9(8), 1295–1301 (2007) doi:10.1089/ars.2007.1620
S. Strübing, H. Metz, K. Mäder, Eur. J. Pharm. Biopharm. 66, 13–119 (2007) doi:10.1016/j.ejpb.2006.09.007
H. Sugimoto, M. Mori, H. Masuda, T. Taga, J. Chem. Soc. Chem. Commun. 962–963 (1986) doi:10.1039/c39860000962
H.M. Swartz, Antioxid. Redox Signal. 6(3), 677–686 (2004) doi:10.1089/152308604773934440
D.S. Vikram, J.L. Zweier, P. Kuppusamy, Antioxid. Redox Signal. 9(10), 1745–1756 (2007) doi:10.1089/ars.2007.1717
L. Werner, J.M. Legeais, M.D. Nagel, G. Renard, J. Biomed. Mater. Res. 46(3), 347–354 (1999) doi:10.1002/(SICI)1097-4636(19990905)46:3<347::AID-JBM6>3.0.CO;2-M
S. Wisel, S.M. Chacko, M.L. Kuppusamy, R.P. Pandian, M. Khan, V.K. Kutala, R.W. Burry, B. Sun, P. Kwiatkowski, P. Kuppusamy, Am. J. Physiol. 292(3), H1254–H1261 (2007)
H. Zhao, J. Zhang, N. Wu, X. Zhang, K. Crowley, A.G. Weber, J. Am. Chem. Soc. 127, 15112–15119 (2005) doi:10.1021/ja052875p
Acknowledgement
The study was supported by NIH grant EB 004031.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Eteshola, E., Pandian, R.P., Lee, S.C. et al. Polymer coating of paramagnetic particulates for in vivo oxygen-sensing applications. Biomed Microdevices 11, 379–387 (2009). https://doi.org/10.1007/s10544-008-9244-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10544-008-9244-x