Abstract
This work reports the fabrication, magnetic characterization and controlled navigation of film-shaped microrobots consisting of a polydimethylsiloxane-NdFeB powder composite material. The fabrication process relies on spin-coating deposition, powder orientation and permanent magnetization. Films with different powder concentrations (10 %, 30 %, 50 % and 70 % w/w) were fabricated and characterized in terms of magnetic properties and magnetic navigation performances (by exploiting an electromagnet-based platform). Standardized data are provided, thus enabling the exploitation of these composite materials in a wide range of applications, from MEMS/microrobot development to biomedical systems. Finally, the possibility to microfabricate free-standing polymeric structures and the biocompatibility of the proposed composite materials is demonstrated.
Similar content being viewed by others
References
J.J. Abbott, Z. Nagy, F. Beyeler, B.J. Nelson, Robotics in the small. IEEE Robot. Autom. Mag. 14, 3 (2007)
H.L. Bumpers, D.G. Janagama, U. Manne, M.D. Basson, V. Katkoori, Nanomagnetic levitation three-dimensional cultures of breast and colorectal cancers. J Surg Res 194, 2 (2015)
G. Chatzipirpiridis, O. Ergeneman, J. Pokki, F. Ullrich, S. Fusco, J.A. Ortega, K.M. Sivaraman, B.J. Nelson, S. Pané, Electroforming of implantable tubular magnetic microrobots for wireless ophthalmologic applications. Adv. Healthc. Mater. 4(2) (2015)
T.S. Chin, Permanent magnet films for applications in microelectromechanical systems. J. Magn. Magn. Mater. 209, 1 (2000)
O. Cugat, J. Delamare, G. Reyne, Magnetic micro-actuators and systems (MAGMAS). IEEE Trans. Mag. 39, 6 (2003)
E. Diller, M. Sitti, Micro-scale mobile robotics. Foundations and Trends in Robotics 2:3, 43–259 (2013)
E. Diller, M. Sitti, Three-dimensional programmable assembly by untethered magnetic robotic micro-grippers. Adv. Funct. Mater. 24, 28 (2014)
M. Dkhil, A. Bolopion, S. Regnier, M. Gauthier, Modeling and experiments of high speed magnetic micromanipulation at the air/liquid interface (In Proc. IEEE/RSJ Int. Conf. Int, Robot, 2014)
S. Floyd, E. Diller, C. Pawashe, M. Sitti, Control methodologies for a heterogeneous group of untethered magnetic micro-robots. Int. J. Robot. Res. 30, 13 (2011)
E.P. Furlani, Permanent magnet and electromechanical devices: materials, analysis, and applications (Academic Press, New York, 2001)
G.G. Genchi, G. Ciofani, I. Liakos, L. Ricotti, L. Ceseracciu, A. Athanassiou, V. Mattoli, Bio/non-bio interfaces: a straightforward method for obtaining long term PDMS/muscle cell biohybrid constructs. Colloids Surf. B Biointerfaces 105, 144–151 (2013)
K.S. Han, S.H Hong, K.I. Kim, J.Y. Cho, K.W. Choi, and H. Lee, Fabrication of 3D nano-structures using reverse imprint lithography. Nanotechnology, 24(4), 045-304. (2013).
F.M. Hsu, W. Fang, Development of two-stage solidification technology for implementing micro structures with liquid magnetic polymer and solid magnetic anisotropic polymer. J. Micromech. Microeng. 24, 9 (2014)
V. Iacovacci, G. Lucarini, L. Ricotti, P. Dario, P.E. Dupont, A. Menciassi, Untethered magnetic millirobot for targeted drug delivery. Biomed. Microdev. 17, 3 (2015)
Y. Jiang, S. Masaoka, M. Uehara, T. Fujita, K. Higuchi, K. Maenaka, Micro-structuring of thick NdFeB films using high-power plasma etching for magnetic MEMS application. J. Micromech. Microeng. 21, 4 (2011)
S. Kim, F. Qiu, S. Kim, A. Ghanbari, C. Moon, L. Zhang, B.J. Nelson, H. Choi, Fabrication and characterization of magnetic microrobots for three-dimensional cell culture and targeted transportation. Adv. Mater. 25, 41 (2013)
M.P. Kummer, J.J. Abbott, B.E. Kratochvil, R. Borer, A. Sengul, B.J. Nelson, OctoMag: an electromagnetic system for 5-DOF wireless micromanipulation. IEEE Trans. Rob. 26, 6 (2010)
S. Laurent, A.A. Saei, S. Behzadi, A. Panahifar, M. Mahmoudi, Superparamagnetic iron oxide nanoparticles for delivery of therapeutic agents: opportunities and challenges. Expert Opin. Drug Deliv. 11, 9 (2014)
H. Li, T.J. Flynn, J.C. Nation, J. Kershaw, L.S. Stephens, C.A. Trinkle, Photopatternable NdFeB polymer micromagnets for microfluidics and microrobotics applications. J. Micromech. Microeng. 23(6) (2013)
G. Lucarini, S. Palagi, A. Levi, B. Mazzolai, P. Dario, A. Menciassi, L. Beccai, Navigation of magnetic microrobots with different user interaction levels. IEEE Trans. Autom. Sci. Eng. 11, 3 (2014)
G. Lucarini, V. Iacovacci, L. Ricotti, N. Comisso, P. Dario, and A. Menciassi, Magnetically driven microrobotic system for cancer cell manipulation, in Proc. IEEE Conf. Eng. Med. Biol. Soc. (2015a). Accepted.
G. Lucarini, M. Mura, G. Ciuti, R. Rizzo, A. Menciassi, Electromagnetic Control System for Capsule Navigation: Novel Concept for Magnetic Capsule Maneuvering and Preliminary Study. J. Med. Biol. Eng. 35, 1–9 (2015b)
S. Martel, Magnetic nanoparticles in medical nanorobotics. J. Nanoparticle Res. 17, 2 (2015)
A. Mata, A.J. Fleischman, S. Roy, Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems. Biomed. Microdev. 7, 4 (2005)
T. Mazzocchi, L. Ricotti, N. Pinzi, A. Menciassi, Parametric design, fabrication and validation of one-way polymeric valves for artificial sphincters. Sensor Actuat. A-Phys. 233, 184–194 (2015)
B.J. Nelson, I.K. Kaliakatsos, J.J. Abbott, Microrobots for minimally invasive medicine. Annu. Rev. Biomed. Eng. 12, 55–85 (2010)
S. Palagi, G. Lucarini, V. Pensabene, A. Levi, B. Mazzolai, A. Menciassi, L. Beccai, Wireless swimming microrobots: design and development of a 2 DoF magnetic-based system (In Proc. IEEE Conf. Robot, Autom, 2012)
B. Pawlowski, J. Töpfer, Permanent magnetic NdFeB thick films. J. Mater. Sci. 39, 4 (2004)
B. Pawlowski, S. Schwarzer, A. Rahmig, J. Töpfer, NdFeB thick films prepared by tape casting. J. Magn. Magn. Mater. 265, 3 (2003)
C. Peters, V. Costanza, S. Pane, B.J. Nelson, C. Hierold, Superparamagnetic hydrogels for two-photon polymerization and their application for the fabrication of swimming microrobots (In Proc, IEEE Transducers, 2015)
R. Pieters, H.W. Tung, S. Charreyron, D.F. Sargent, B.J. Nelson, RodBot: a rolling microrobot for micromanipulation (In Proc. IEEE Conf. Robot, Autom, 2015)
F.N. Pirmoradi, L. Cheng, M. Chiao, A magnetic poly (dimethylesiloxane) composite membrane incorporated with uniformly dispersed, coated iron oxide nanoparticles. J. Micromech. Microeng. 20, 1 (2010)
F. Qiu, L. Zhang, K.E. Peyer, M. Casarosa, A. Franco-Obregón, H. Choi, B.J. Nelson, Noncytotoxic artificial bacterial flagella fabricated from biocompatible ORMOCOMP and iron coating. J. Mater. Chem. B. 2(4) (2014a)
T. Qiu, T. Lee, A.G. Mark, K.I. Morozov, R. Münster, O. Mierka, A.M.L. St. Turek, P. Fischer, Swimming by reciprocal motion at low Reynolds number. Nature communications. 5, 5119 (2014b)
L. Ricotti, A. Menciassi, Nanotechnology in biorobotics: opportunities and challenges. J. Nanoparticle Res. 17, 2 (2015)
L. Ricotti, T. Ranzani, V. Calarota, A. Menciassi, Thin and flexible pressure/deformation sensors based on piezoelectric nanocomposites (In Proc, IEEE Sensors, 2014)
L. Ricotti, A. Cafarelli, V. Iacovacci, L. Vannozzi, A. Menciassi, Advanced micro-nano-bio systems for future targeted therapies. Curr. Nanosci. 11, 2 (2015)
M.M. Said, J. Yunas, B.Y. Majlis, B. Bais, and A.A. Hamzah, Design and optimization of magnetic particles embedded in PDMS membrane. In IEEE Micro and Nanoelectronics (RSM) (2013).
M. Sitti, Microscale and nanoscale robotics systems [grand challenges of robotics]. IEEE Robot. Autom. Mag. 14, 1 (2007)
B. Ślusarek, I. Dudzikowski, Application of permanent magnets made from NdFeB powder and from mixtures of powders in DC motors. J. Magn. Magn. Mater. 239, 1 (2002)
M. Suter, L. Zhang, E.C. Siringil, C. Peters, T. Luehmann, O. Ergeneman, C. Hierold, Superparamagnetic microrobots: fabrication by two-photon polymerization and biocompatibility. Biomed. Microdev. 15, 6 (2013)
F. Ullrich, C. Bergeles, J. Pokki, O. Ergeneman, S. Erni, G. Chatzipirpiridis, B.J. Nelson, Mobility experiments with microrobots for minimally invasive intraocular SurgeryMicrorobot experiments for intraocular surgery. Invest. Ophthalmol. Vis. Sci. 54, 4 (2013)
V. Valdiglesias, G. Kiliç, C. Costa, N. Fernández-Bertólez, E. Pásaro, J.P. Teixeira, B. Laffon, Effects of iron oxide nanoparticles: cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity. Environ. Mol. Mutagen. 56, 2 (2015)
L. Vannozzi, L. Ricotti, M. Cianchetti, C. Bearzi, C. Gargioli, R. Rizzi, P. Dario, A. Menciassi, Self-assembly of polydimethylsiloxane structures from 2D to 3D for bio-hybrid actuation. Bioinspir. Biomim. 10, 5 (2015)
K. Vollmers, D.R. Frutiger, B.E. Kratochvil, B.J. Nelson, Wireless resonant magnetic microactuator for untethered mobile microrobots. Appl. Phys. Lett. 92, 14 (2008)
H. Wörn, J. Seyfried, A. Buerkle, and F. Schmoeckel, Flexible microrobots for micro assembly tasks, In Proc. IEEE Int. Symp. Micromech..Human Sci. (2000).
S. Yim, M. Sitti, Design and rolling locomotion of a magnetically actuated soft capsule endoscope. IEEE Trans. Robot. 28, 1 (2012)
L. Zhang, J.J. Abbott, L. Dong, B.E. Kratochvil, D. Bell, B.J. Nelson, Artificial bacterial flagella: fabrication and magnetic control. Appl. Phys. Lett. 94, 6 (2009)
Acknowledgments
The authors would like to thank Francesca Pignatelli for her support in sample magnetization. This work was supported in part by the GeT Small project (TarGeted Therapy at Small Scale), funded by the Scuola Superiore di Studi Universitari e di Perfezionamento Sant’Anna (Pisa, Italy) and by the Italian MIUR FIRB project “RINAME” (RBAP114AMK). The authors would also like to thank the Fondazione Cassa di Risparmio di Lucca (Lucca, Italy), for providing financial support for this study, in the framework of the SUAVES project (Artificial Urinary System based on bladder and sphincter endoprostheses).
Author information
Authors and Affiliations
Corresponding author
Additional information
V. Iacovacci and G. Lucarini equally contributed to this work.
Electronic supplementary material
Rights and permissions
About this article
Cite this article
Iacovacci, V., Lucarini, G., Innocenti, C. et al. Polydimethylsiloxane films doped with NdFeB powder: magnetic characterization and potential applications in biomedical engineering and microrobotics . Biomed Microdevices 17, 112 (2015). https://doi.org/10.1007/s10544-015-0024-0
Published:
DOI: https://doi.org/10.1007/s10544-015-0024-0