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Erschienen in: Journal of Inherited Metabolic Disease 1/2011

01.02.2011 | Homocysteine and B-Vitamin Metabolism

Cobalamin status in children

verfasst von: Anne-Lise Bjørke-Monsen, Per Magne Ueland

Erschienen in: Journal of Inherited Metabolic Disease | Ausgabe 1/2011

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Abstract

Cobalamin and the metabolic markers methylmalonic acid and total homocysteine undergo marked changes during childhood. In breastfed infants a metabolic profile indicative of cobalamin deficiency is common. Symptoms of cobalamin deficiency in children differ with age, presenting a continuum from subtle developmental delay to life-threatening clinical conditions. The symptoms may be difficult to detect, particularly in infants, and there tends to be a diagnostic delay of several months in this age group. Several reports show that even moderate deficiency in children may be harmful, and long-term consequences of neurological deterioration may persist after cobalamin deficiency has been treated. Given the crucial role of cobalamin for normal growth and development, possible widespread infantile deficiency needs attention. Cobalamin deficiency should be considered a differential diagnosis in children with subtle symptoms, and strategies to prevent cobalamin deficiency in mothers and children should be addressed.
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Metadaten
Titel
Cobalamin status in children
verfasst von
Anne-Lise Bjørke-Monsen
Per Magne Ueland
Publikationsdatum
01.02.2011
Verlag
Springer Netherlands
Erschienen in
Journal of Inherited Metabolic Disease / Ausgabe 1/2011
Print ISSN: 0141-8955
Elektronische ISSN: 1573-2665
DOI
https://doi.org/10.1007/s10545-010-9119-1

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