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Erschienen in: Breast Cancer Research and Treatment 2/2009

01.01.2009 | Clinical Trial

HER-2/neu expression in primary and metastatic breast cancer

verfasst von: Elyse E. Lower, Eleanor Glass, Robbin Blau, Stacy Harman

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2009

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Abstract

Introduction Trastuzumab is a highly effective therapy for the treatment of HER-2/neu positive breast cancer. To maximize benefit and minimize unnecessary toxicity, patient selection is essential. Currently HER-2/neu analysis is routinely performed only for primary invasive breast cancers, and trastuzumab therapy is recommended based on primary analysis only. Methods Using immunohistochemistry, we performed a retrospective study comparing HER-2/neu expression in original primary to subsequent metastatic breast cancers. Results Tumors from 382 patients with metastatic breast cancer were studied. In 254 cases (66%) both primary and metastatic lesions were concordant. In 90 cases the primary lesion was HER-2/neu positive with the metastatic lesion negative; whereas, in 37 cases the primary lesion was HER-2/neu negative and the metastatic lesion positive. Primary HER-2/neu immunostaining was associated with a negative predictive value of 35.7%. Although all four groups were similar at diagnosis, survival differences were noted with the best survival experienced by patients with initial primary lesions HER-2/neu negative and subsequent metastatic lesions positive. Patients with hormone receptor and HER-2/neu positive primary lesions who received tamoxifen were more likely to have HER-2/neu positive metastasis. Conclusions The significant discordance between HER-2/neu expression in primary and metastatic tumors suggests that determination of HER-2/neu status in metastatic disease should be attempted.
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Metadaten
Titel
HER-2/neu expression in primary and metastatic breast cancer
verfasst von
Elyse E. Lower
Eleanor Glass
Robbin Blau
Stacy Harman
Publikationsdatum
01.01.2009
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2009
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-008-9931-6

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