Introduction
Methods
Study population
Histologic examination
Statistical methods
Results
LI progression and breast cancer risk in multiple biopsy cohort
Rate of LI progression by patient age in the multiple biopsy cohort
LI status at subsequent biopsy | ||||
---|---|---|---|---|
0–25 % TDLU (N = 92) (%) | 26–50 % TDLU (N = 238) (%) | 51–75 % TDLU (N = 317) (%) | >75 % TDLU (N = 468) (%) | |
LI status at initial biopsy | ||||
0–25 % TDLU | 77 (83.7) | 84 (35.3) | 75 (23.7) | 64 (13.7) |
26–50 % TDLU | 9 (9.8) | 95 (39.9) | 100 (31.5) | 82 (17.5) |
51–75 % TDLU | 3 (3.3) | 41 (17.2) | 102 (32.2) | 102 (21.8) |
>75 % TDLU | 3 (3.3) | 18 (7.6) | 40 (12.6) | 220 (47.0) |
Characteristic | LI progression (N = 507) (%) | LI stasis (N = 327) (%) | Multivariate | |
---|---|---|---|---|
Odds ratio (95 % CI) | Wald p value | |||
Time from Index to later benign biopsy | <.001 | |||
<2 | 44 (8.7) | 82 (25.1) | 1.00 (ref) | |
2–5 | 98 (19.3) | 97 (29.7) | 2.10 (1.21, 3.65) | |
5–10 | 130 (25.6) | 86 (26.3) | 3.58 (2.08, 6.14) | |
10+ | 235 (46.4) | 62 (19.0) | 9.18 (5.30, 15.89) | |
Age at index bx | <.001 | |||
<45 | 273 (53.8) | 189 (57.8) | 1.00 (ref) | |
45–55 | 192 (37.9) | 105 (32.1) | 2.24 (1.50, 3.35) | |
55+ | 42 (8.3) | 33 (10.1) | 1.89 (1.00, 3.58) | |
Involution at index | <.001 | |||
0–25 % TDLU | 223 (44.0) | 77 (23.5) | 1.00 (ref) | |
26–50 % TDLU | 182 (35.9) | 104 (31.8) | 0.50 (0.33, 0.76) | |
51–75 % TDLU | 102 (20.1) | 146 (44.6) | 0.16 (0.10, 0.26) | |
HRT ever/never | 0.482 | |||
No | 172 (39.1) | 113 (41.5) | 1.00 (ref) | |
Yes | 268 (60.9) | 159 (58.5) | 0.88 (0.62, 1.26) |
Effect of LI progression or stasis on breast cancer risk
Characteristic | Total (N = 834) | Events (N = 82) (%) | Multivariate | |
---|---|---|---|---|
Hazard ratio (95 % CI) | Wald p valuea
| |||
Involution at index | 0.527 | |||
0–25 % TDLU | 300 | 27 (9.0) | 1.00 (ref) | |
26–50 % TDLU | 286 | 29 (10.1) | 0.87 (0.51, 1.48) | |
51–75 % TDLU | 248 | 26 (10.5) | 0.72 (0.40, 1.28) | |
Change in involution | 0.036 | |||
Progression | 507 | 39 (7.7) | 1.00 (ref) | |
Stasis | 327 | 43 (13.1) | 1.63 (1.03, 2.57) | |
Overall impression | <.001 | |||
NP | 475 | 31 (6.5) | 1.00 (ref) | |
PDWA | 317 | 42 (13.2) | 2.10 (1.31, 3.35) | |
AH | 42 | 9 (21.4) | 5.49 (2.56, 11.81) |
Characteristic | No. Women | Person years | Observed events | Expected events | SIR (95 % CI)a
|
p valueb
|
---|---|---|---|---|---|---|
Overall | 834 | 11,865 | 82 | 42.15 | 1.95 (1.55, 2.41) | |
Involution at 2nd Bx | 0.096 | |||||
0–25 % TDLU | 89 | 1622 | 14 | 4.76 | 2.94 (1.61, 4.93) | |
26–50 % TDLU | 220 | 3299 | 22 | 10.25 | 2.15 (1.34, 3.25) | |
51–75 % TDLU | 277 | 3998 | 31 | 14.81 | 2.09 (1.42, 2.97) | |
>75 % TDLU | 248 | 2946 | 15 | 12.33 | 1.22 (0.68, 2.01) | |
Change in involution | 0.054 | |||||
Progression | 507 | 6557 | 39 | 24.51 | 1.59 (1.13, 2.17) | |
No progression | 327 | 5308 | 43 | 17.64 | 2.44 (1.76, 3.28) | |
Impression at 2nd Bx | 0.034 | |||||
NP | 387 | 5856 | 27 | 19.32 | 1.40 (0.92, 2.03) | |
PDWA | 352 | 5034 | 42 | 18.92 | 2.22 (1.60, 3.00) | |
AH | 91 | 915 | 12 | 3.66 | 3.28 (1.69, 5.72) |