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Erschienen in: Breast Cancer Research and Treatment 1/2021

03.01.2021 | Clinical trial

Clinical significance of HER2 status in T1bN0 breast cancer: a nationwide study from the Korean Breast Cancer Society

verfasst von: Young-Joon Kang, Se Jeong Oh, Hoon Choi, Shijin Cho, Chang-Hyun Shin, Chaiwon Kim, Joohyun Woo, JungSun Lee, Heung Kyu Park, Han-Byoel Lee, Woo Chul Noh, Yong-Seok Kim

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 1/2021

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Abstract

Purpose

The prognosis of patients with node-negative T1b tumors according to human epidermal growth factor receptor 2 (HER2) status is not known. This group of patients has not been studied in the available randomized trials. The objective of this study was to evaluate the survival of patients in a monoethnic group diagnosed with T1b lymph node-negative breast cancer depending on HER2 status.

Methods

We analyzed 3110 patients with T1bN0M0 breast cancer whose data were deposited into the Korean Breast Cancer Society Registry database between 2000 and 2009. Overall survival (OS) and breast cancer-specific survival (BCSS) were compared according to HER2 status.

Results

Among all patients, 494 (15.9%) had HER2-positive breast cancer. At a mean follow-up of 93 months, 108 deaths and 86 breast cancer-specific deaths were noted among all patients. There was no significant difference in OS between the HER2-negative and HER2-positive groups (p = 0.103). The same result was observed for BCSS. However, in the subgroup of estrogen receptor (ER)-positive women, HER2-negative patients had a better BCSS prognosis than HER2-positive patients (p = 0.025). Multivariate analysis also indicated a significant difference in BCSS in the ER-positive subgroup (HR 2.60; 95% CI 1.15–5.87; p = 0.021).

Conclusion

This study analyzed a large nationwide and monoethnic cohort and found a significant difference only in BCSS in the ER-positive subgroup according to HER2 status. Anti-HER2 therapy may be considered in HER2-positive and ER-positive patients with small, node-negative breast cancer.
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Metadaten
Titel
Clinical significance of HER2 status in T1bN0 breast cancer: a nationwide study from the Korean Breast Cancer Society
verfasst von
Young-Joon Kang
Se Jeong Oh
Hoon Choi
Shijin Cho
Chang-Hyun Shin
Chaiwon Kim
Joohyun Woo
JungSun Lee
Heung Kyu Park
Han-Byoel Lee
Woo Chul Noh
Yong-Seok Kim
Publikationsdatum
03.01.2021
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 1/2021
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-020-06017-2

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