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Cancer Causes & Control
Erschienen in: Cancer Causes & Control 4/2006

01.05.2006 | Special Section on Cancer and Rhythm

Biological Clocks and Shift Work: Circadian Dysregulation and Potential Long-term Effects

verfasst von: Erhard Haus, Michael Smolensky

Erschienen in: Cancer Causes & Control | Ausgabe 4/2006

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Abstract

Long-term epidemiologic studies on large numbers of night and rotating shift workers have suggested an increase in the incidence of breast and colon cancer in these populations. These studies suffer from poor definition and quantification of the work schedules of the exposed subjects. Against this background, the pathophysiology of phase shift and phase adaptation is reviewed. A phase shift as experienced in night and rotating shift work involves desynchronization at the molecular level in the circadian oscillators in the central nervous tissue and in most peripheral tissues of the body. There is a change in the coordination between oscillators with transient loss of control by the master-oscillator (the Suprachiasmatic Nucleus, SCN) in the hypothalamus. The implications of the pathophysiology of phase shift are discussed for long-term health effects and for the design of ergonomic work schedules minimizing the adverse health effects upon the worker.
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Metadaten
Titel
Biological Clocks and Shift Work: Circadian Dysregulation and Potential Long-term Effects
verfasst von
Erhard Haus
Michael Smolensky
Publikationsdatum
01.05.2006
Verlag
Kluwer Academic Publishers
Erschienen in
Cancer Causes & Control / Ausgabe 4/2006
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-005-9015-4

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