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Cancer Causes & Control

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01.04.2007 | Review Article

Physical activity and endometrial cancer risk: a review of the current evidence, biologic mechanisms and the quality of physical activity assessment methods

verfasst von: Anne E. Cust, Bruce K. Armstrong, Christine M. Friedenreich, Nadia Slimani, Adrian Bauman

Erschienen in: Cancer Causes & Control | Ausgabe 3/2007

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Abstract

Objectives

To (1) determine the nature of the association between physical activity and endometrial cancer risk; (2) assess the contribution of variation in the quality of physical activity measurement to inconsistencies in study results; and (3) review the biologic mechanisms that might mediate possible effects of physical activity on risk.

Methods

We reviewed and summarized all published epidemiologic studies examining physical activity and endometrial cancer risk, and evidence relating to possible biologic mechanisms. We assigned each study a quality score for physical activity measurement.

Results

Fourteen of the 18 studies showed a convincing or possible protective effect of physical activity on endometrial cancer risk, with an average relative risk reduction of around 30%. A dose–response relation was observed in 7 of 13 studies. The quality score was not related to the observed strength of association or the presence of a dose–response relation. There was epidemiologic and biologic evidence that vigorous activity, as well as light and moderate intensity activities, such as housework, gardening or walking for transportation, may reduce risk.

Conclusions

Physical activity probably has a protective role in endometrial cancer development. More epidemiologic and biologic evidence is needed to make conclusive recommendations on optimal types, characteristics or time periods of physical activity.

Kaaks R, Lukanova A, Kurzer MS (2002) Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev 11:1531–1543PubMed

Amant F, Moerman P, Neven P, Timmerman D, Van Limbergen E, Vergote I (2005) Endometrial cancer. Lancet 366:491–505PubMedCrossRef

Calle EE, Kaaks R (2004) Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4:579–591PubMedCrossRef

Weight control and physical activity (2002) In: Vaino H, Bianchini F, (eds) IARC Handbook for Cancer Prevention, vol. 6. Lyon, France: IARC Press

Friedenreich CM (2001) Physical activity and cancer prevention: from observational to intervention research. Cancer Epidemiol Biomarkers Prev 10:287–301PubMed

Thune I, Furberg AS (2001) Physical activity and cancer risk: dose–response and cancer, all sites and site-specific. Med Sci Sports Exerc 33:S530–50 discussion S609–10PubMedCrossRef

Kaaks R, Lukanova A (2001) Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc 60:91–106PubMedCrossRef

Key TJ, Allen NE, Verkasalo PK, Banks E (2001) Energy balance and cancer: the role of sex hormones. Proc Nutr Soc 60:81–89PubMed

Levine JA, Lanningham-Foster LM, McCrady SK et al (2005) Interindividual variation in posture allocation: possible role in human obesity. Science 307:584–586PubMedCrossRef

10.

Levine JA, Vander Weg MW, Hill JO, Klesges RC (2006) Non-exercise activity thermogenesis: the crouching tiger hidden dragon of societal weight gain. Arterioscler Thromb Vasc Biol 26:729–736PubMedCrossRef

11.

McTiernan A, Tworoger SS, Ulrich CM et al (2004) Effect of exercise on serum estrogens in postmenopausal women: a 12-month randomized clinical trial. Cancer Res 64:2923–2928PubMedCrossRef

12.

Modugno F, Ness RB, Chen C, Weiss NS (2005) Inflammation and endometrial cancer: a hypothesis. Cancer Epidemiol Biomarkers Prev 14:2840–2847PubMedCrossRef

13.

Atkinson C, Lampe JW, Tworoger SS et al (2004) Effects of a moderate intensity exercise intervention on estrogen metabolism in postmenopausal women. Cancer Epidemiol Biomarkers Prev 13:868–874PubMed

14.

Luo Z, Saha AK, Xiang X, Ruderman NB (2005) AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci 26:69–76PubMedCrossRef

15.

Physical Activity and Health: A Report of the Surgeon General (1996) Atlanta, GA: National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention

16.

Bauman A, Ford I, Armstrong T (2001) Trends in population levels of reported physical activity in Australia 1997, 1999 and 2000. Australian Sports Commission, Canberra

17.

Janz KF (2006) Physical activity in epidemiology: moving from questionnaire to objective measurement. Br J Sports Med 40:191–192PubMedCrossRef

18.

Willett W (1989) An overview of issues related to the correction of non-differential exposure measurement error in epidemiologic studies. Stat Med 8:1031–1040 discussion 1071–3PubMed

19.

Armstrong BK, White E, Saracci R (1992) Principles of exposure measurement in epidemiology. In: Kelsey JL, Marmot MG, Stolley PD, Vessey MP (eds) Monographs in epidemiology and biostatistics. Oxford University Press, Oxford

20.

Jacobs DR Jr, Ainsworth BE, Hartman TJ, Leon AS (1993) A simultaneous evaluation of 10 commonly used physical activity questionnaires. Med Sci Sports Exerc 25:81–91PubMedCrossRef

21.

R Development Core Team (2005) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3–900051-07-0, URL http://www.R-project.org

22.

Powell KE, Thompson PD, Caspersen CJ, Kendrick JS (1987) Physical activity and the incidence of coronary heart disease. Annu Rev Public Health 8:253–287PubMedCrossRef

23.

Levi F, La Vecchia C, Negri E, Franceschi S (1993) Selected physical activities and the risk of endometrial cancer. Br J Cancer 67:846–851PubMed

24.

Shu XO, Hatch MC, Zheng W, Gao YT, Brinton LA (1993) Physical activity and risk of endometrial cancer. Epidemiology 4:342–349PubMedCrossRef

25.

Pukkala E, Poskiparta M, Apter D, Vihko V (1993) Life-long physical activity and cancer risk among Finnish female teachers. Eur J Cancer Prev 2:369–376PubMedCrossRef

26.

Sturgeon SR, Brinton LA, Berman ML et al (1993) Past and present physical activity and endometrial cancer risk. Br J Cancer 68:584–589PubMed

27.

Dosemeci M, Hayes RB, Vetter R et al (1993) Occupational physical activity, socioeconomic status, and risks of 15 cancer sites in Turkey. Cancer Causes Control 4:313–321PubMedCrossRef

28.

Zheng W, Shu XO, McLaughlin JK, Chow WH, Gao YT, Blot WJ (1993) Occupational physical activity and the incidence of cancer of the breast, corpus uteri, and ovary in Shanghai. Cancer 71:3620–3624PubMedCrossRef

29.

Hirose K, Tajima K, Hamajima N et al (1996) Subsite (cervix/endometrium)-specific risk and protective factors in uterus cancer. Jpn J Cancer Res 87:1001–1009PubMed

30.

Olson SH, Vena JE, Dorn JP et al (1997) Exercise, occupational activity, and risk of endometrial cancer. Ann Epidemiol 7:46–53PubMedCrossRef

31.

Goodman MT, Hankin JH, Wilkens LR et al (1997) Diet, body size, physical activity, and the risk of endometrial cancer. Cancer Res 57:5077–5085PubMed

32.

Moradi T, Nyren O, Bergstrom R et al (1998) Risk for endometrial cancer in relation to occupational physical activity: a nationwide cohort study in Sweden. Int J Cancer 76:665–670PubMedCrossRef

33.

Terry P, Baron JA, Weiderpass E, Yuen J, Lichtenstein P, Nyren O (1999) Lifestyle and endometrial cancer risk: a cohort study from the Swedish Twin Registry. Int J Cancer 82:38–42PubMedCrossRef

34.

Salazar-Martinez E, Lazcano-Ponce EC, Lira-Lira GG et al (2000) Case–control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control 11:707–711PubMedCrossRef

35.

Moradi T, Weiderpass E, Signorello LB, Persson I, Nyren O, Adami HO (2000) Physical activity and postmenopausal endometrial cancer risk (Sweden). Cancer Causes Control 11:829–837PubMedCrossRef

36.

Littman AJ, Voigt LF, Beresford SA, Weiss NS (2001) Recreational physical activity and endometrial cancer risk. Am J Epidemiol 154:924–933PubMedCrossRef

37.

Colbert LH, Lacey JV Jr, Schairer C, Albert P, Schatzkin A, Albanes D (2003) Physical activity and risk of endometrial cancer in a prospective cohort study (United States). Cancer Causes Control 14:559–567PubMedCrossRef

38.

Furberg AS, Thune I (2003) Metabolic abnormalities (hypertension, hyperglycemia and overweight), lifestyle (high energy intake and physical inactivity) and endometrial cancer risk in a Norwegian cohort. Int J Cancer 104:669–676PubMedCrossRef

39.

Schouten LJ, Goldbohm RA, van den Brandt PA (2004) Anthropometry, physical activity, and endometrial cancer risk: results from the Netherlands Cohort Study. J Natl Cancer Inst 96:1635–1638PubMedCrossRef

40.

Matthews CE, Xu WH, Zheng W et al (2005) Physical activity and risk of endometrial cancer: a report from the Shanghai endometrial cancer study. Cancer Epidemiol Biomarkers Prev 14:779–785PubMedCrossRef

41.

Ainsworth BE, Haskell WL, Whitt MC et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32:S498–504PubMedCrossRef

42.

United States Department of Labor (1993) Selected characteristics of occupations defined in the revised dictionary of occupational titles. US Government Printing Office, Washington, DC

43.

Rennie KL, Wareham NJ (1998) The validation of physical activity instruments for measuring energy expenditure: problems and pitfalls. Public Health Nutr 1:265–271PubMedCrossRef

44.

Ainsworth BE, Sternfeld B, Slattery ML, Daguise V, Zahm SH (1998) Physical activity and breast cancer: evaluation of physical activity assessment methods. Cancer 83:611–620PubMedCrossRef

45.

Cohen J (1968) Weighted kappa: nominal scale agreement with provision for scaled agreement or partial credit. Psychol Bull 70:213–220CrossRefPubMed

46.

Shephard RJ (2003) Limits to the measurement of habitual physical activity by questionnaires. Br J Sports Med 37:197–206 discussion 206PubMedCrossRef

47.

Slattery ML, Jacobs DR Jr (1995) Assessment of ability to recall physical activity of several years ago. Ann Epidemiol 5:292–296PubMedCrossRef

48.

Richardson MT, Leon AS, Jacobs DR Jr, Ainsworth BE, Serfass R (1994) Comprehensive evaluation of the Minnesota Leisure Time Physical Activity Questionnaire. J Clin Epidemiol 47:271–281PubMedCrossRef

49.

Blair SN, Dowda M, Pate RR et al (1991) Reliability of long-term recall of participation in physical activity by middle-aged men and women. Am J Epidemiol 133:266–275PubMed

50.

Matthews CE, Shu XO, Yang G et al (2003) Reproducibility and validity of the Shanghai Women’s Health Study physical activity questionnaire. Am J Epidemiol 158:1114–1122PubMedCrossRef

51.

Taylor HL, Jacobs DR Jr, Schucker B, Knudsen J, Leon AS, Debacker G (1978) A questionnaire for the assessment of leisure time physical activities. J Chronic Dis 31:741–755PubMedCrossRef

52.

Purdie DM, Green AC (2001) Epidemiology of endometrial cancer. Best Pract Res Clin Obstet Gynaecol 15:341–354PubMedCrossRef

53.

Brinton LA, Berman ML, Mortel R et al (1992) Reproductive, menstrual, and medical risk factors for endometrial cancer: results from a case–control study. Am J Obstet Gynecol 167:1317–1325PubMed

54.

Mayer-Davis EJ, D’Agostino R Jr, Karter AJ et al (1998) Intensity and amount of physical activity in relation to insulin sensitivity: the Insulin Resistance Atherosclerosis Study. JAMA 279:669–674PubMedCrossRef

55.

Borghouts LB, Keizer HA (2000) Exercise and insulin sensitivity: a review. Int J Sports Med 21:1–12PubMedCrossRef

56.

Irwin ML, Mayer-Davis EJ, Addy CL et al (2000) Moderate-intensity physical activity and fasting insulin levels in women: the Cross-Cultural Activity Participation Study. Diabetes Care 23:449–454PubMed

57.

Allen NE, Appleby PN, Kaaks R, Rinaldi S, Davey GK, Key TJ (2003) Lifestyle determinants of serum insulin-like growth-factor-I (IGF-I), C-peptide and hormone binding protein levels in British women. Cancer Causes Control 14:65–74PubMedCrossRef

58.

Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Rimm EB (2003) Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res 11:1055–1064PubMed

59.

Rajaram S, Baylink DJ, Mohan S (1997) Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 18:801–831PubMedCrossRef

60.

Irwin ML, Ainsworth BE, Mayer-Davis EJ, Addy CL, Pate RR, Durstine JL (2002) Physical activity and the metabolic syndrome in a tri-ethnic sample of women. Obes Res 10:1030–1037PubMedCrossRef

61.

Kaaks R, Lukanova A (2002) Effects of weight control and physical activity in cancer prevention: role of endogenous hormone metabolism. Ann N Y Acad Sci 963:268–281PubMedCrossRef

62.

Lukanova A, Zeleniuch-Jacquotte A, Lundin E et al (2004) Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer. Int J Cancer 108:262–268PubMedCrossRef

63.

Key TJ, Pike MC (1988) The dose–effect relationship between ‘unopposed’ oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk. Br J Cancer 57:205–212PubMed

64.

Frisch RE, Wyshak G, Vincent L (1980) Delayed menarche and amenorrhea in ballet dancers. N Engl J Med 303:17–19PubMedCrossRef

65.

Warren MP (1980) The effects of exercise on pubertal progression and reproductive function in girls. J Clin Endocrinol Metab 51:1150–1157PubMed

66.

Frisch RE, Gotz-Welbergen AV, McArthur JW et al (1981) Delayed menarche and amenorrhea of college athletes in relation to age of onset of training. JAMA 246:1559–1563PubMedCrossRef

67.

Bullen BA, Skrinar GS, Beitins IZ, von Mering G, Turnbull BA, McArthur JW (1985) Induction of menstrual disorders by strenuous exercise in untrained women. N Engl J Med 312:1349–1353PubMedCrossRef

68.

Dale E, Gerlach DH, Wilhite AL (1979) Menstrual dysfunction in distance runners. Obstet Gynecol 54:47–53PubMedCrossRef

69.

Broocks A, Pirke KM, Schweiger U et al (1990) Cyclic ovarian function in recreational athletes. J Appl Physiol 68:2083–2086PubMed

70.

Bernstein L, Ross RK, Lobo RA, Hanisch R, Krailo MD, Henderson BE (1987) The effects of moderate physical activity on menstrual cycle patterns in adolescence: implications for breast cancer prevention. Br J Cancer 55:681–685PubMed

71.

Loucks AB (2003) Energy availability, not body fatness, regulates reproductive function in women. Exerc Sport Sci Rev 31:144–148PubMedCrossRef

72.

Henderson BE, Casagrande JT, Pike MC, Mack T, Rosario I, Duke A (1983) The epidemiology of endometrial cancer in young women. Br J Cancer 47:749–756PubMed

73.

Forney JP, Milewich L, Chen GT et al (1981) Aromatization of androstenedione to estrone by human adipose tissue in vitro. Correlation with adipose tissue mass, age, and endometrial neoplasia. J Clin Endocrinol Metab 53:192–199PubMed

74.

Sherman B, Wallace R, Bean J, Schlabaugh L (1981) Relationship of body weight to menarcheal and menopausal age: implications for breast cancer risk. J Clin Endocrinol Metab 52:488–493PubMed

75.

Frisch RE, Wyshak G, Albright NL et al (1987) Lower lifetime occurrence of breast cancer and cancers of the reproductive system among former college athletes. Am J Clin Nutr 45:328–335PubMed

76.

La Vecchia C, Franceschi S, Decarli A, Gallus G, Tognoni G (1984) Risk factors for endometrial cancer at different ages. J Natl Cancer Inst 73:667–671PubMed

77.

Ravussin E (2005) Physiology. A NEAT way to control weight? Science 307:530–531PubMedCrossRef

78.

Levine JA (2004) Non-exercise activity thermogenesis (NEAT). Nutr Rev 62:S82–97PubMedCrossRef

79.

King AC, Tribble DL (1991) The role of exercise in weight regulation in nonathletes. Sports Med 11:331–349PubMed

80.

Nelson ME, Meredith CN, Dawson-Hughes B, Evans WJ (1988) Hormone and bone mineral status in endurance-trained and sedentary postmenopausal women. J Clin Endocrinol Metab 66:927–933PubMedCrossRef

81.

Verkasalo PK, Thomas HV, Appleby PN, Davey GK, Key TJ (2001) Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom). Cancer Causes Control 12:47–59PubMedCrossRef

82.

Cauley JA, Gutai JP, Kuller LH, LeDonne D, Powell JG (1989) The epidemiology of serum sex hormones in postmenopausal women. Am J Epidemiol 129:1120–1131PubMed

83.

Purohit A, Newman SP, Reed MJ (2002) The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer. Breast Cancer Res 4:65–69PubMedCrossRef

84.

Moldoveanu AI, Shephard RJ, Shek PN (2001) The cytokine response to physical activity and training. Sports Med 31:115–144PubMedCrossRef

85.

Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H (1998) The cytokine response to strenuous exercise. Can J Physiol Pharmacol 76:505–511PubMedCrossRef

86.

Shephard RJ, Shek PN (1998) Associations between physical activity and susceptibility to cancer: possible mechanisms. Sports Med 26:293–315PubMedCrossRef

87.

Nehlsen-Cannarella SL (1998) Cellular responses to moderate and heavy exercise. Can J Physiol Pharmacol 76:485–489PubMedCrossRef

88.

Matthews CE, Fowke JH, Dai Q et al (2004) Physical activity, body size, and estrogen metabolism in women. Cancer Causes Control 15:473–481PubMedCrossRef

89.

Bentz AT, Schneider CM, Westerlind KC (2005) The relationship between physical activity and 2-hydroxyestrone, 16alpha-hydroxyestrone, and the 2/16 ratio in premenopausal women (United States). Cancer Causes Control 16:455–461PubMedCrossRef

90.

Campbell KL, Westerlind KC, Harber VJ, Friedenreich CM, Courneya KS (2005) Associations between aerobic fitness and estrogen metabolites in premenopausal women. Med Sci Sports Exerc 37:585–592PubMedCrossRef

91.

Kelesidis I, Kelesidis T, Mantzoros CS (2006) Adiponectin and cancer: a systematic review. Br J Cancer 94:1221–1225PubMedCrossRef

92.

Ainsworth BE (2000) Issues in the assessment of physical activity in women. Res Q Exerc Sport 71:S37–42PubMed

93.

Pate RR, Pratt M, Blair SN et al (1995) Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273:402–407PubMedCrossRef

94.

National Physical Activity Guidelines for Adults (2005) Canberra: Australian Government Department of Health and Ageing

95.

McTiernan A, Schwartz RS, Potter J, Bowen D (1999) Exercise clinical trials in cancer prevention research: a call to action. Cancer Epidemiol Biomarkers Prev 8:201–207PubMed

96.

Bassett DR Jr (2000) Validity and reliability issues in objective monitoring of physical activity. Res Q Exerc Sport 71:S30–36PubMed

97.

Freedson PS, Miller K (2000) Objective monitoring of physical activity using motion sensors and heart rate. Res Q Exerc Sport 71:S21–29PubMed

98.

Westerterp KR (1999) Physical activity assessment with accelerometers. Int J Obes Relat Metab Disord 23 Suppl 3:S45–49PubMedCrossRef

99.

Rodriguez DA, Brown AL, Troped PJ (2005) Portable global positioning units to complement accelerometry-based physical activity monitors. Med Sci Sports Exerc 37:S572–581PubMedCrossRef

100.

Pober DM, Staudenmayer J, Raphael C, Freedson PS (2006) Development of novel techniques to classify physical activity mode using accelerometers. Med Sci Sports Exerc 38:1626–1634PubMedCrossRef

101.

Crouter SE, Clowers KG, Bassett DR Jr (2006) A novel method for using accelerometer data to predict energy expenditure. J Appl Physiol 100:1324–1331PubMedCrossRef

102.

Levin S, Jacobs DR Jr, Ainsworth BE, Richardson MT, Leon AS (1999) Intra-individual variation and estimates of usual physical activity. Ann Epidemiol 9:481–488PubMedCrossRef

Titel: Physical activity and endometrial cancer risk: a review of the current evidence, biologic mechanisms and the quality of physical activity assessment methods
verfasst von: Anne E. Cust
Bruce K. Armstrong
Christine M. Friedenreich
Nadia Slimani
Adrian Bauman
Publikationsdatum: 01.04.2007
Verlag: Kluwer Academic Publishers
Erschienen in: Cancer Causes & Control / Ausgabe 3/2007
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-006-0094-7

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Physical activity and endometrial cancer risk: a review of the current evidence, biologic mechanisms and the quality of physical activity assessment methods

Abstract

Objectives

Methods

Results

Conclusions

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

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