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Erschienen in: Cancer Causes & Control 5/2009

01.07.2009 | Original Paper

Vaccination history and risk of non-hodgkin lymphoma: a population-based, case–control study

verfasst von: Heather A. Lankes, Angela J. Fought, Andrew M. Evens, Dennis D. Weisenburger, Brian C.-H. Chiu

Erschienen in: Cancer Causes & Control | Ausgabe 5/2009

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Abstract

Objective

As factors that alter the immune system have been implicated in non-Hodgkin lymphoma (NHL) etiology, it is of interest to explore the association between vaccination and risk of NHL. Results of few epidemiologic studies conducted thus far are inconsistent, and only one has examined the association by histologic subtype.

Subjects

A population-based, case–control study of 387 patients with NHL and 535 controls conducted in Nebraska between 1999 and 2002.

Methods

Information on vaccination for tetanus, polio, influenza, smallpox, and tuberculosis, as well as important environmental factors, was collected by telephone interview. Risk was estimated by odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for confounders.

Results

We found that NHL risk was inversely associated with ever receiving a polio (OR = 0.59, CI = 0.40–0.87) or smallpox (OR = 0.71, CI = 0.51–0.98) vaccination, and positively associated with influenza vaccination (OR = 1.53, CI = 1.14–2.06). No significant association was found for tetanus or tuberculosis vaccination. The patterns of association were similar between men and women. Analysis by histologic subtypes showed that polio vaccination was associated with a lower risk of follicular (OR = 0.54, CI = 0.31–0.92) and chronic lymphocytic leukemia/small lymphocytic lymphomas (OR = 0.29, CI = 0.12–0.69) and smallpox vaccination was associated with a lower risk of marginal zone lymphoma (OR = 0.41, CI = 0.19–0.88). In contrast, ever receiving an influenza vaccination was associated with a higher risk of follicular (OR = 1.98, CI = 1.23–3.18) and diffuse large B cell lymphomas (OR = 1.88, CI = 1.13–3.12).

Conclusion

Risk of NHL is inversely associated with polio and smallpox vaccination and positively associated with influenza vaccination. These associations appear to differ by histologic subtype.
Literatur
2.
Zurück zum Zitat Filipovich AH, Mathur A, Kamat D, Shapiro RS (1992) Primary immunodeficiencies: genetic risk factors for lymphoma. Cancer Res 52:5465–5467 Filipovich AH, Mathur A, Kamat D, Shapiro RS (1992) Primary immunodeficiencies: genetic risk factors for lymphoma. Cancer Res 52:5465–5467
4.
Zurück zum Zitat Goedert JJ (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 27:390–401PubMed Goedert JJ (2000) The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 27:390–401PubMed
9.
Zurück zum Zitat Jaffe ES (2004) Common threads of mucosa-associated lymphoid tissue lymphoma pathogenesis: from infection to translocation. J Natl Cancer Inst 96:571–573PubMedCrossRef Jaffe ES (2004) Common threads of mucosa-associated lymphoid tissue lymphoma pathogenesis: from infection to translocation. J Natl Cancer Inst 96:571–573PubMedCrossRef
10.
Zurück zum Zitat Pozzato G, Mazzaro C, Crovatto M et al (1994) Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood 84:3047–3053PubMed Pozzato G, Mazzaro C, Crovatto M et al (1994) Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia. Blood 84:3047–3053PubMed
12.
Zurück zum Zitat Bernstein L, Ross RK (1992) Prior medication use and health history as risk factors for non-Hodgkin’s lymphoma: preliminary results from a case–control study in Los Angeles County. Cancer Res 52:5510–5515 Bernstein L, Ross RK (1992) Prior medication use and health history as risk factors for non-Hodgkin’s lymphoma: preliminary results from a case–control study in Los Angeles County. Cancer Res 52:5510–5515
13.
Zurück zum Zitat Holly EA, Bracci PM (2003) Population-based study of non-Hodgkin lymphoma, histology, and medical history among human immunodeficiency virus-negative participants in San Francisco. Am J Epidemiol 158:316–327. doi:10.1093/aje/kwg145 PubMedCrossRef Holly EA, Bracci PM (2003) Population-based study of non-Hodgkin lymphoma, histology, and medical history among human immunodeficiency virus-negative participants in San Francisco. Am J Epidemiol 158:316–327. doi:10.​1093/​aje/​kwg145 PubMedCrossRef
19.
Zurück zum Zitat Breslow NE, Day NE (1993) Statistical methods in cancer research, vol 1. The analysis of case–control studies, IARC Sci Pub Breslow NE, Day NE (1993) Statistical methods in cancer research, vol 1. The analysis of case–control studies, IARC Sci Pub
20.
Zurück zum Zitat Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) World health organization classification of tumors. pathology and genetics of tumors of haematopoietic and lymphoid tissues. IARC Press, Lyon Jaffe ES, Harris NL, Stein H, Vardiman JW (2001) World health organization classification of tumors. pathology and genetics of tumors of haematopoietic and lymphoid tissues. IARC Press, Lyon
21.
Zurück zum Zitat Maldonado G, Greenland S (1993) Simulation study of confounder-selection strategies. Am J Epidemiol 138:923–936PubMed Maldonado G, Greenland S (1993) Simulation study of confounder-selection strategies. Am J Epidemiol 138:923–936PubMed
23.
Zurück zum Zitat Holly EA, Lele C, Bracci PM, McGrath MS (1999) Case–control study of non-Hodgkin’s lymphoma among women and heterosexual men in the San Francisco Bay Area, California. Am J Epidemiol 150:375–389PubMed Holly EA, Lele C, Bracci PM, McGrath MS (1999) Case–control study of non-Hodgkin’s lymphoma among women and heterosexual men in the San Francisco Bay Area, California. Am J Epidemiol 150:375–389PubMed
24.
31.
Zurück zum Zitat Shenson D, Dimartino D, Bolen J, Campbell M, Lu PJ, Singleton JA (2005) Validation of self-reported pneumococcal vaccination in behavioral risk factor surveillance surveys: experience from the sickness prevention achieved through regional collaboration (SPARC) program. Vaccine 23:1015–1020. doi:10.1016/j.vaccine.2004.07.039 PubMedCrossRef Shenson D, Dimartino D, Bolen J, Campbell M, Lu PJ, Singleton JA (2005) Validation of self-reported pneumococcal vaccination in behavioral risk factor surveillance surveys: experience from the sickness prevention achieved through regional collaboration (SPARC) program. Vaccine 23:1015–1020. doi:10.​1016/​j.​vaccine.​2004.​07.​039 PubMedCrossRef
Metadaten
Titel
Vaccination history and risk of non-hodgkin lymphoma: a population-based, case–control study
verfasst von
Heather A. Lankes
Angela J. Fought
Andrew M. Evens
Dennis D. Weisenburger
Brian C.-H. Chiu
Publikationsdatum
01.07.2009
Verlag
Springer Netherlands
Erschienen in
Cancer Causes & Control / Ausgabe 5/2009
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-008-9259-x

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