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Erschienen in: Cancer Causes & Control 7/2010

01.07.2010 | Original paper

Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

verfasst von: Simona Ognjanovic, Jennifer Yamamoto, Barbara Saltzman, Adrian Franke, Miodrag Ognjanovic, Lance Yokochi, Thomas Vogt, Robert Decker, Loïc Le Marchand

Erschienen in: Cancer Causes & Control | Ausgabe 7/2010

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Abstract

Chronic inflammation, which is suspected to play a role in the development of colorectal cancer (CRC), has rarely been studied in colorectal adenoma. We investigated the inter-relationships of serum levels of the inflammatory proteins CRP and in IL-6, single nucleotide polymorphisms (SNPs) in the CRP (rs1205, rs1130864, rs1800947) and IL6 (rs1800795) genes, and lifestyle factors with colorectal adenoma in a sigmoidoscopy-based case–control study of 271 adenoma cases and 539 age-, sex-, and race/ethnicity-matched controls in Hawaii. We found no association of serum CRP or IL-6 levels with the risk of adenoma. A multiple regression with stepwise selection identified elevated BMI, Caucasian and Native Hawaiian versus Japanese race/ethnicity, and current smoking as being associated with significantly higher serum CRP and IL-6 levels. Female versus male gender was also associated with higher CRP levels and older age with higher IL-6 levels. The C allele of rs1205 and the A allele of rs1130864 were significantly associated with higher serum CRP levels (p trend: 0.0002 and 0.01, respectively), as well as with a decreased adenoma risk [rs1205: OR for CT and CC vs. TT = 0.69 (95% CI: 0.48–0.98) and 0.53 (0.34–0.83), respectively, p trend = 0.008; rs1130864: OR for GA and AA versus GG = 0.65 (0.45–0.93) and 0.74 (0.31–1.76), respectively, p trend = 0.04]. The findings of lower serum CRP and IL-6 levels in Japanese (a group with a high CRC risk) and of a decreased adenoma risk observed for alleles associated with higher circulating CRP levels suggest a protective effect for CRP in early colorectal neoplasia that warrants further study.
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Metadaten
Titel
Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population
verfasst von
Simona Ognjanovic
Jennifer Yamamoto
Barbara Saltzman
Adrian Franke
Miodrag Ognjanovic
Lance Yokochi
Thomas Vogt
Robert Decker
Loïc Le Marchand
Publikationsdatum
01.07.2010
Verlag
Springer Netherlands
Erschienen in
Cancer Causes & Control / Ausgabe 7/2010
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9540-7

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