Erschienen in:
01.07.2012 | Original paper
Sun exposure and risk of lymphoid neoplasms in Singapore
verfasst von:
Kin-Yoke Wong, Bee-Choo Tai, Sin-Eng Chia, Ponnudurai Kuperan, Khai-Mun Lee, Soon-Thye Lim, Susan Loong, Benjamin Mow, Siok-Bian Ng, Leonard Tan, Soo-Yong Tan, Suat-Hoon Tan, Miriam Tao, Alvin Wong, Gee-Chuan Wong, Adeline Seow
Erschienen in:
Cancer Causes & Control
|
Ausgabe 7/2012
Einloggen, um Zugang zu erhalten
Abstract
Background
Epidemiologic studies have reported an inverse association between sun exposure and non-Hodgkin lymphoma (NHL), but these have been almost exclusively conducted in Western populations residing in temperate locations. We evaluated the association between personal outdoor sun exposure and risk of malignant lymphomas in Singapore.
Methods
A hospital-based case–control study of 541 incident cases of lymphoid neoplasms and 830 controls were recruited during 2004–2008. Participants were interviewed regarding recreational or occupational outdoor activities during childhood and in adulthood. Basic demographics and potential confounders were also collected. Odds ratios (OR) and 95 % confidence intervals (CI) were calculated using unconditional logistic regression analysis.
Results
Compared with individuals who did not have regular sun exposure, a lower risk of NHL was observed for those who reported regular exposure on non-school days during childhood [OR, 0.62; 95 % CI, 0.46–0.83] and non-working days in adulthood [OR, 0.70; 95 % CI, 0.51–0.97]. The protective effect was more evident among women.
Conclusion
Our findings support an inverse relationship between intermittent sun exposure and the risk of NHL. These findings are consistent with the growing evidence from various countries, but further studies, especially prospective studies, are needed in Asian populations.