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Erschienen in: Cancer Causes & Control 8/2014

01.08.2014 | Original paper

History of periodontal disease diagnosis and lung cancer incidence in the Women’s Health Initiative Observational Study

verfasst von: Xiaodan Mai, Michael J. LaMonte, Kathleen M. Hovey, Ngozi Nwizu, Jo L. Freudenheim, Mine Tezal, Frank Scannapieco, Andrew Hyland, Christopher A. Andrews, Robert J. Genco, Jean Wactawski-Wende

Erschienen in: Cancer Causes & Control | Ausgabe 8/2014

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Abstract

Purpose

While some evidence suggests that periodontal disease (PD) might be positively associated with lung cancer, prospective studies in women are limited. Previous findings may reflect residual confounding by smoking. The study aims to determine whether history of PD diagnosis is associated with incident lung cancer in a large cohort of postmenopausal women.

Methods

Prospective analyses were conducted in a cohort of 77,485 postmenopausal women enrolled in the Women’s Health Initiative Observational Study. History of PD (prevalence of 26.1 %) was self-reported, and 754 incident lung cancer cases occurred during an average 6.8 (SD ± 2.6) years of follow-up. Cox proportional hazards regression analysis was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs).

Results

Overall, PD was positively associated with lung cancer risk after adjusting for detailed smoking history including smoking status and pack-years of smoking (HR 1.24, 95 % CI 1.07–1.45). There was a positive additive interaction between PD with pack-years of smoking (p = 0.02), suggesting a potential synergistic effect between PD and smoking intensity on lung cancer. The association between PD and lung cancer was stronger in former smokers. When restricted to never-smokers, PD was not associated with lung cancer (HR 1.02, 95 % CI 0.68–1.53).

Conclusions

Periodontal disease was not independently associated with lung cancer in non-smoking postmenopausal women. However, smoking and PD jointly increased lung cancer risk beyond that expected from the sum of the each effect separately. The potential synergism between PD and smoking on lung cancer warrants further examination.
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Metadaten
Titel
History of periodontal disease diagnosis and lung cancer incidence in the Women’s Health Initiative Observational Study
verfasst von
Xiaodan Mai
Michael J. LaMonte
Kathleen M. Hovey
Ngozi Nwizu
Jo L. Freudenheim
Mine Tezal
Frank Scannapieco
Andrew Hyland
Christopher A. Andrews
Robert J. Genco
Jean Wactawski-Wende
Publikationsdatum
01.08.2014
Verlag
Springer International Publishing
Erschienen in
Cancer Causes & Control / Ausgabe 8/2014
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-014-0405-3

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