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Erschienen in: Cancer Causes & Control 10/2014

01.10.2014 | Original paper

Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis

verfasst von: Sabrina Schlesinger, Sabine Siegert, Manja Koch, Jessica Walter, Nils Heits, Sebastian Hinz, Gunnar Jacobs, Jochen Hampe, Clemens Schafmayer, Ute Nöthlings

Erschienen in: Cancer Causes & Control | Ausgabe 10/2014

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Abstract

Purpose

Aim of this study was to investigate the association between postdiagnosis body mass index (BMI) and all-cause mortality in colorectal cancer (CRC) survivors in a prospective study and meta-analysis.

Methods

We conducted a prospective cohort study on 2,143 CRC survivors in Germany. Participants were recruited to the study on average 4 years after diagnosis, and postdiagnosis BMI was assessed at recruitment using a self-administered questionnaire. CRC survivors were followed up for a mean time of 3.5 years. The association between BMI and all-cause mortality was investigated using multivariable Cox proportional hazards models. Additionally, we performed a meta-analysis of studies on postdiagnosis BMI and all-cause mortality (n = 5, including this study) by applying random-effects models.

Results

In the prospective analysis, 349 participants died. BMI was not statistically significantly associated with all-cause mortality. Compared to normal weight survivors, the hazard ratios (HRs) [95 % confidence interval (CI)] for all-cause mortality in underweight, overweight and obese survivors were 1.65 (0.79–3.45), 0.80 (0.62–1.03) and 0.84 (0.62–1.14), respectively. In the meta-analysis, individuals with underweight were at increased risk for all-cause mortality [HR (95 % CI) 1.72 (1.18–2.49)], whereas individuals with overweight had a lower risk [HR (95 % CI) 0.79 (0.71–0.88)], compared to normal weight subjects. For obesity, the risk of mortality was also reduced with only borderline significance [HR (95 % CI) 0.88 (0.77–1.00)].

Conclusions

While the present study as well as single previously published studies showed that overweight was associated with a non-significant reduced risk for all-cause mortality, our meta-analysis indicated a decreased mortality risk among overweight CRC survivors.
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Metadaten
Titel
Postdiagnosis body mass index and risk of mortality in colorectal cancer survivors: a prospective study and meta-analysis
verfasst von
Sabrina Schlesinger
Sabine Siegert
Manja Koch
Jessica Walter
Nils Heits
Sebastian Hinz
Gunnar Jacobs
Jochen Hampe
Clemens Schafmayer
Ute Nöthlings
Publikationsdatum
01.10.2014
Verlag
Springer International Publishing
Erschienen in
Cancer Causes & Control / Ausgabe 10/2014
Print ISSN: 0957-5243
Elektronische ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-014-0435-x

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