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Erschienen in: The International Journal of Cardiovascular Imaging 4/2008

01.04.2008 | Original Paper

Characteristics of coronary plaques before angiographic progression determined by Multi-Slice CT

verfasst von: Alexander W. Leber, Franz von Ziegler, Alexander Becker, Christoph R. Becker, Maximilian Reiser, Gerhard Steinbeck, Andreas Knez, Peter Boekstegers

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 4/2008

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Abstract

The aim of the present study was to characterize coronary plaques by Multi-Slice Computed Tomography (Siemens sensation 16, Forcheim, Germany) before significant angiographic progression occurred and to compare them to non-progressing lesions. The MSCT-morphology of coronary plaques leading to a rapid angiographic disease progression is not yet studied. In a series of 68 patients who were scheduled for surveillance angiography 6 months later, MSCT-angiography was done shortly after the baseline catheterisation-procedure. After surveillance angiography rapid progressive lesions with an increase of the stenosis severity of >20% were identified and analysed on the baseline MSCT-scan and were compared to non-progressing lesions. Six months after coronary stenting we observed significant progression of de novo stenoses in 10/438 coronary segments. The progression of four lesions lead to angina pectoris symptoms and the remaining six lesions progressed silently. Analysis of the lesion morphology by MSCT revealed that 5/10 (50%) progressing lesions were non-calcified 3/10 (30%) were predominantly non-calcified and 2/10 (20%) were mainly calcified on the baseline MSCT-scan. In the 428 segments without disease progression atherosclerotic lesions were found in 225 segments on MSCT. Non-calcified plaques were identified in 46 (20%), predominantly non-calcified lesions in 58 (26%) and predominantly calcified lesions in 121 (54%) segments. The average number of diseased coronary segments between patients with and without lesion progression was not significantly different between progressors and non-progressors with a higher prevalence of non-calcified segments in the progressor group (1.1 vs. 0.63). Rapid progression of the angiographic stenosis severity during a 6 months period occurs most frequently in coronary segments revealing non-calcified or predominantly non-calcified plaques as determined by MSCT, whereas lesion progression is rare in predominantly calcified segments. This represents first evidence that non-calcified lesions may be involved in the process of plaque rupture.
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Metadaten
Titel
Characteristics of coronary plaques before angiographic progression determined by Multi-Slice CT
verfasst von
Alexander W. Leber
Franz von Ziegler
Alexander Becker
Christoph R. Becker
Maximilian Reiser
Gerhard Steinbeck
Andreas Knez
Peter Boekstegers
Publikationsdatum
01.04.2008
Verlag
Springer Netherlands
Erschienen in
The International Journal of Cardiovascular Imaging / Ausgabe 4/2008
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-007-9278-9

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