Skip to main content
Erschienen in: The International Journal of Cardiovascular Imaging 8/2009

01.12.2009 | Original Paper

Prevalence of noncardiac findings on low dose 64-slice computed tomography used for attenuation correction in myocardial perfusion imaging with SPECT

verfasst von: Lars Husmann, Fuminari Tatsugami, Ursina Aepli, Bernhard A. Herzog, Ines Valenta, Patrick Veit-Haibach, Ronny R. Buechel, Aju P. Pazhenkottil, Oliver Gaemperli, Nina Burkhard, Christophe A. Wyss, Philipp A. Kaufmann

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 8/2009

Einloggen, um Zugang zu erhalten

Abstract

Electrocardiogram (ECG)-triggered, low dose computed tomography (CT) is increasingly used for attenuation correction in myocardial perfusion imaging (MPI) with SPECT. The purpose of the study was to assess the prevalence of relevant noncardiac findings in the field-of-view of such attenuation correction CT scans. Five hundred and eighty-two consecutive patients (211 female, 371 male; mean age: 64 ± 11 years; BMI: 27.7 ± 5.3 kg/m2) underwent 64-slice, ECG-triggered CT scanning for attenuation correction of MPI with SPECT. Relevant findings were defined as abnormalities that required clinical or radiological follow-up. Noncardiac findings were detected in 400 patients (68.7%). In 196 patients (33.7%) 226 relevant findings were detected. Findings included noncalcified pulmonary nodules (n = 156), interstitial lung disease (n = 6), pleural effusion (n = 20), pneumonia (n = 1), aortic aneurysm (n = 5), aortic dissection (n = 4), enlarged mediastinal lymph nodes (n = 5), mediastinal tumor (n = 3), breast abnormalities (n = 3), liver cirrhosis (n = 5), liver mass (n = 5), ascites (n = 5), splenomegaly (n = 2), renal mass (n = 1), hydronephrosis (n = 1), adrenal mass (n = 3), and bone metastasis (n = 1). As low dose 64-slice CT scans used for attenuation correction in MPI with SPECT reveal a high prevalence of noncardiac pathologic findings with potential clinical relevance, a systematic review of the CT scans appears mandatory.
Literatur
1.
Zurück zum Zitat Masood Y, Liu YH, Depuey G et al (2005) Clinical validation of SPECT attenuation correction using x-ray computed tomography-derived attenuation maps: multicenter clinical trial with angiographic correlation. J Nucl Cardiol 12:676–686CrossRefPubMed Masood Y, Liu YH, Depuey G et al (2005) Clinical validation of SPECT attenuation correction using x-ray computed tomography-derived attenuation maps: multicenter clinical trial with angiographic correlation. J Nucl Cardiol 12:676–686CrossRefPubMed
2.
Zurück zum Zitat Fricke E, Fricke H, Weise R et al (2005) Attenuation correction of myocardial SPECT perfusion images with low-dose CT: evaluation of the method by comparison with perfusion PET. J Nucl Med 46:736–744PubMed Fricke E, Fricke H, Weise R et al (2005) Attenuation correction of myocardial SPECT perfusion images with low-dose CT: evaluation of the method by comparison with perfusion PET. J Nucl Med 46:736–744PubMed
3.
Zurück zum Zitat Preuss R, Weise R, Lindner O et al (2008) Optimisation of protocol for low dose CT-derived attenuation correction in myocardial perfusion SPECT imaging. Eur J Nucl Med Mol Imaging 35:1133–1141CrossRefPubMed Preuss R, Weise R, Lindner O et al (2008) Optimisation of protocol for low dose CT-derived attenuation correction in myocardial perfusion SPECT imaging. Eur J Nucl Med Mol Imaging 35:1133–1141CrossRefPubMed
4.
Zurück zum Zitat Schepis T, Gaemperli O, Koepfli P et al (2007) Use of coronary calcium score scans from stand-alone multislice computed tomography for attenuation correction of myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging 34:11–19CrossRefPubMed Schepis T, Gaemperli O, Koepfli P et al (2007) Use of coronary calcium score scans from stand-alone multislice computed tomography for attenuation correction of myocardial perfusion SPECT. Eur J Nucl Med Mol Imaging 34:11–19CrossRefPubMed
5.
Zurück zum Zitat Singh B, Bateman TM, Case JA et al (2007) Attenuation artifact, attenuation correction, and the future of myocardial perfusion SPECT. J Nucl Cardiol 14:153–164CrossRefPubMed Singh B, Bateman TM, Case JA et al (2007) Attenuation artifact, attenuation correction, and the future of myocardial perfusion SPECT. J Nucl Cardiol 14:153–164CrossRefPubMed
6.
Zurück zum Zitat Rivero A, Santana C, Folks RD et al (2006) Attenuation correction reveals gender-related differences in the normal values of transient ischemic dilation index in rest-exercise stress sestamibi myocardial perfusion imaging. J Nucl Cardiol 13:338–344CrossRefPubMed Rivero A, Santana C, Folks RD et al (2006) Attenuation correction reveals gender-related differences in the normal values of transient ischemic dilation index in rest-exercise stress sestamibi myocardial perfusion imaging. J Nucl Cardiol 13:338–344CrossRefPubMed
7.
Zurück zum Zitat Hunold P, Schmermund A, Seibel RM et al (2001) Prevalence and clinical significance of accidental findings in electron-beam tomographic scans for coronary artery calcification. Eur Heart J 22:1748–1758CrossRefPubMed Hunold P, Schmermund A, Seibel RM et al (2001) Prevalence and clinical significance of accidental findings in electron-beam tomographic scans for coronary artery calcification. Eur Heart J 22:1748–1758CrossRefPubMed
8.
Zurück zum Zitat Horton KM, Post WS, Blumenthal RS et al (2002) Prevalence of significant noncardiac findings on electron-beam computed tomography coronary artery calcium screening examinations. Circulation 106:532–534CrossRefPubMed Horton KM, Post WS, Blumenthal RS et al (2002) Prevalence of significant noncardiac findings on electron-beam computed tomography coronary artery calcium screening examinations. Circulation 106:532–534CrossRefPubMed
9.
Zurück zum Zitat Schragin JG, Weissfeld JL, Edmundowicz D et al (2004) Non-cardiac findings on coronary electron beam computed tomography scanning. J Thorac Imaging 19:82–86CrossRefPubMed Schragin JG, Weissfeld JL, Edmundowicz D et al (2004) Non-cardiac findings on coronary electron beam computed tomography scanning. J Thorac Imaging 19:82–86CrossRefPubMed
10.
Zurück zum Zitat MacMahon H, Austin JH, Gamsu G et al (2005) Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology 237:395–400CrossRefPubMed MacMahon H, Austin JH, Gamsu G et al (2005) Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society. Radiology 237:395–400CrossRefPubMed
11.
Zurück zum Zitat Lau CL, Harpole DH Jr (2000) Noninvasive clinical staging modalities for lung cancer. Semin Surg Oncol 18:116–123CrossRefPubMed Lau CL, Harpole DH Jr (2000) Noninvasive clinical staging modalities for lung cancer. Semin Surg Oncol 18:116–123CrossRefPubMed
12.
Zurück zum Zitat Sebastia C, Pallisa E, Quiroga S et al (1999) Aortic dissection: diagnosis and follow-up with helical CT. Radiographics 19:45–60 quiz 149–150PubMed Sebastia C, Pallisa E, Quiroga S et al (1999) Aortic dissection: diagnosis and follow-up with helical CT. Radiographics 19:45–60 quiz 149–150PubMed
13.
Zurück zum Zitat Onuma Y, Tanabe K, Nakazawa G et al (2006) Noncardiac findings in cardiac imaging with multidetector computed tomography. J Am Coll Cardiol 48:402–406CrossRefPubMed Onuma Y, Tanabe K, Nakazawa G et al (2006) Noncardiac findings in cardiac imaging with multidetector computed tomography. J Am Coll Cardiol 48:402–406CrossRefPubMed
14.
Zurück zum Zitat Gil BN, Ran K, Tamar G et al (2007) Prevalence of significant noncardiac findings on coronary multidetector computed tomography angiography in asymptomatic patients. J Comput Assist Tomogr 31:1–4CrossRefPubMed Gil BN, Ran K, Tamar G et al (2007) Prevalence of significant noncardiac findings on coronary multidetector computed tomography angiography in asymptomatic patients. J Comput Assist Tomogr 31:1–4CrossRefPubMed
15.
Zurück zum Zitat Goetze S, Pannu HK, Wahl RL (2006) Clinically significant abnormal findings on the “nondiagnostic” CT portion of low-amperage-CT attenuation-corrected myocardial perfusion SPECT/CT studies. J Nucl Med 47:1312–1318PubMed Goetze S, Pannu HK, Wahl RL (2006) Clinically significant abnormal findings on the “nondiagnostic” CT portion of low-amperage-CT attenuation-corrected myocardial perfusion SPECT/CT studies. J Nucl Med 47:1312–1318PubMed
Metadaten
Titel
Prevalence of noncardiac findings on low dose 64-slice computed tomography used for attenuation correction in myocardial perfusion imaging with SPECT
verfasst von
Lars Husmann
Fuminari Tatsugami
Ursina Aepli
Bernhard A. Herzog
Ines Valenta
Patrick Veit-Haibach
Ronny R. Buechel
Aju P. Pazhenkottil
Oliver Gaemperli
Nina Burkhard
Christophe A. Wyss
Philipp A. Kaufmann
Publikationsdatum
01.12.2009
Verlag
Springer Netherlands
Erschienen in
The International Journal of Cardiovascular Imaging / Ausgabe 8/2009
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-009-9490-x

Weitere Artikel der Ausgabe 8/2009

The International Journal of Cardiovascular Imaging 8/2009 Zur Ausgabe

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.