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Erschienen in: The International Journal of Cardiovascular Imaging 2/2013

01.02.2013 | Original Paper

Gender differences in coronary plaque composition and burden detected in symptomatic patients referred for coronary computed tomographic angiography

verfasst von: Waqas Qureshi, Michael J. Blaha, Khurram Nasir, Mouaz H. Al-Mallah

Erschienen in: The International Journal of Cardiovascular Imaging | Ausgabe 2/2013

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Abstract

We assessed gender differences in coronary plaque burden and composition amongst symptomatic patients referred for coronary computed tomographic angiography (CCTA). Over all, 916 symptomatic patients who were referred for a clinically indicated CCTA were included in the study. CCTAs were interpreted on a per-segment basis for plaque composition (non-calcified, calcified, or mixed) and stenosis severity. A stenosis of ≥50 % was considered obstructive coronary artery disease. Among 916 patients, 498 (54.3 %) patients were women. Obstructive stenosis was found in 11 % of women compared to 21 % of men (p < 0.0001). Men had significantly higher plaque prevalence, 67.9 % versus 51.6 % in women (unadjusted OR 1.98; 95 % CI, 1.51–2.60). This remained significant after adjusting for age and potential confounders (adjusted OR 2.96; 95 % CI, 2.01–4.36). A similar relationship existed for all three plaque subtypes. Men were also more likely to have mixed plaque burden (adjusted OR 1.24; 95 % CI, 1.08–1.43) than women without any significant differences in regards to the other plaque sub-types. In conclusion, symptomatic women have a lower prevalence of obstructive coronary artery disease and are less likely to have mixed coronary plaque compared to symptomatic men. Future studies are needed to determine the prognostic implications of these findings.
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Metadaten
Titel
Gender differences in coronary plaque composition and burden detected in symptomatic patients referred for coronary computed tomographic angiography
verfasst von
Waqas Qureshi
Michael J. Blaha
Khurram Nasir
Mouaz H. Al-Mallah
Publikationsdatum
01.02.2013
Verlag
Springer Netherlands
Erschienen in
The International Journal of Cardiovascular Imaging / Ausgabe 2/2013
Print ISSN: 1569-5794
Elektronische ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-012-0098-1

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