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Early left ventricular remodeling and subclinical cardiac dysfunction in systemic lupus erythematosus: a three-dimensional speckle tracking study

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Abstract

The article aimed to detect the early cardiac dysfunction in patients with systemic lupus erythematosus (SLE) and predict the relationships between the strain parameters and the disease activities. Three-dimensional speckle-tracking echocardiography was performed to measure left ventricular (LV) structures and global strains on 63 subjects (41 SLE patients with preserved EF and 22 healthy controls). The SLE disease activity was assessed using the SLE Disease Activity Index (SLEDAI), and all the SLE patients were further divided into two subgroups according to disease severity. SLEDAI scores 0–8 were defined as group A, 9–20 were defined as group B. Results indicated that all components of left ventricle global strain [global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS)] were significantly reduced in SLE patients. GLS, GRS, GCS had positive correlation with LVEF respectively (r = 0.619, 0.845, 0.91, absolute value, all P < 0.05). The E/e′, LVEDVI, LVESVI, LVM, LVMI were increased in all SLE patients (all P < 0.05). In subgroups, GLS and GRS were decreased in group B. Multiple linear regressions analysis indicate that the SLEDAI score was a predictive factor for damage of GLS and GRS. These results indicate that myocardial damage and LV remodeling still occur in SLE patients even with normal EF. The severe disease activity followed with worsening myocardial injury. SLE disease activity might be a potential driver of LV damages.

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Acknowledgements

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Natural Science Foundation of China (81771851) to Jing Wang and the National Natural Science Foundation of China (81530056; 81727805) to Mingxing Xie.

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Author notes

  1. Wenhui Deng and Mingxing Xie contributed equally to this work.

Authors and Affiliations

  1. Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Wenhui Deng, Mingxing Xie, Qing Lv, Yuman Li, Lingyun Fang & Jing Wang

  2. Hubei Province Key Lab of Molecular Imaging, Wuhan, 430022, China

    Wenhui Deng, Mingxing Xie, Qing Lv, Yuman Li, Lingyun Fang & Jing Wang

Authors
  1. Wenhui Deng
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  2. Mingxing Xie
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  3. Qing Lv
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  4. Yuman Li
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  5. Lingyun Fang
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  6. Jing Wang
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Correspondence to Jing Wang.

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The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

Ethical approval

The study design, manner of data collection, and analysis were approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology (S976). All participants signed the informed consent forms, and all data used were anonymized. Three minors as well as their legal guardian(s) had signed a written informed consent.

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Informed consent was obtained from all individual participants included in the study.

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Deng, W., Xie, M., Lv, Q. et al. Early left ventricular remodeling and subclinical cardiac dysfunction in systemic lupus erythematosus: a three-dimensional speckle tracking study. Int J Cardiovasc Imaging 36, 1227–1235 (2020). https://doi.org/10.1007/s10554-020-01816-6

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  • DOI: https://doi.org/10.1007/s10554-020-01816-6

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