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Erschienen in: Cancer and Metastasis Reviews 2/2008

01.06.2008

A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins

verfasst von: Hugh K. Arnold, Rosalie C. Sears

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 2/2008

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Abstract

Loss or inhibition of the serine/threonine protein phosphatase 2A (PP2A) has revealed a critical tumor suppressor function for PP2A. However, PP2A has also been shown to have important roles in cell cycle progression and survival. Therefore, PP2A is not a typical tumor suppressor. This is most likely due to the fact that PP2A represents a large number of different holoenzymes. Further understanding of PP2A function(s), and especially its tumor suppressor activity, will depend largely on our ability to determine specific targets for these different PP2A holoenzymes and to gain an understanding of how these targets confer tumor suppressor activity or contribute to cell cycle progression and cell survival. Recent work has identified c-Myc as a target of the PP2A holoenzyme, PP2A-B56α. This holoenzyme also negatively regulates β-catenin expression and modulates the anti-apoptotic activity of Bcl2, thus characterizing PP2A-B56α as a tumor suppressor PP2A holoenzyme. This review will focus on the role of PP2A-B56α in regulating c-Myc and will place this tumor suppressor activity of PP2A within the context of its other tumor suppressor functions. Finally, the mechanism(s) through which PP2A-B56α tumor suppressor activity may be lost in cancer will be discussed.
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Metadaten
Titel
A tumor suppressor role for PP2A-B56α through negative regulation of c-Myc and other key oncoproteins
verfasst von
Hugh K. Arnold
Rosalie C. Sears
Publikationsdatum
01.06.2008
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 2/2008
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-008-9128-9

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