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Cancer and Metastasis Reviews

Erschienen in:

01.06.2009

Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

verfasst von: Ren Xu, Aaron Boudreau, Mina J. Bissell

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1-2/2009

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Abstract

Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ’s microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly ‘encoded’ by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra—to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.

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Titel: Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices
verfasst von: Ren Xu
Aaron Boudreau
Mina J. Bissell
Publikationsdatum: 01.06.2009
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1-2/2009
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-008-9178-z

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Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices

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