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Cancer and Metastasis Reviews

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01.12.2010 | NON-THEMATIC REVIEW

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

verfasst von: Carlos A. Castaneda, Hernán Cortes-Funes, Henry L. Gomez, Eva M. Ciruelos

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 4/2010

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Abstract

The phosphatidyl inositol 3-kinase (PI3K)/Akt pathway mediates the effects of a variety of extracellular signals in a number of cellular processes including cell growth, proliferation, and survival. The alteration of integrants of this pathway through mutation of its coding genes increases the activation status of the signaling and can thus lead to cellular transformation. The frequent dysregulation of the PI3K/Akt pathway in breast cancer (BC) and the mediation of this pathway in different processes characteristically implicated in tumorigenesis have attracted the interest of this pathway in BC; however, a more comprehensive understanding of the signaling intricacies is necessary to develop clinical applications of the modulation of this pathway in this pathology. We review a series of experiments examining the contribution of alteration of integrants of this signaling network to human BC and we make an update of the information about the effect of the modulation of this pathway in this cancer.

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Titel: The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer
verfasst von: Carlos A. Castaneda
Hernán Cortes-Funes
Henry L. Gomez
Eva M. Ciruelos
Publikationsdatum: 01.12.2010
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 4/2010
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-010-9261-0

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Springer Medizin

The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer

Abstract

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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