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Cancer and Metastasis Reviews
Erschienen in: Cancer and Metastasis Reviews 3-4/2013

01.12.2013 | NON-THEMATIC REVIEW

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis

verfasst von: Nicole Beauchemin, Azadeh Arabzadeh

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 3-4/2013

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Abstract

The discovery of the carcinoembryonic antigen (CEA) as a tumor marker for colorectal cancer some 50 years ago became the first step in the identification of a much larger family of 12 carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) with surprisingly diverse functions in cell adhesion, in intracellular and intercellular signaling, and during complex biological processes such as cancer progression, inflammation, angiogenesis, and metastasis. The development of proper molecular and biochemical tools and mouse models has enabled bidirectional translation of the CEACAM network biology. Indeed, CEACAM1, CEACAM5, and CEACAM6 are now considered valid clinical biomarkers and promising therapeutic targets in melanoma, lung, colorectal, and pancreatic cancers. These fascinating proteins illustrate how a better understanding of the CEACAM family of cell adhesion molecules reveals their functional link to the underlying disease and lead to new monitoring and targeting opportunities.
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Metadaten
Titel
Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis
verfasst von
Nicole Beauchemin
Azadeh Arabzadeh
Publikationsdatum
01.12.2013
Verlag
Springer US
Erschienen in
Cancer and Metastasis Reviews / Ausgabe 3-4/2013
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-013-9444-6

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