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Erschienen in:

28.01.2020

Bariatric interventions in obesity treatment and prevention in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis

verfasst von: Kuan-Wen Wang, Salma Ladhani, Brianna Empringham, Carol Portwine, Adam Fleming, Laura Banfield, Janatani Balakumaran, Lisa Sarpong, E. Danielle Sims, Alexander Nicholas Popa, Lehana Thabane, M. Constantine Samaan

Erschienen in: Cancer and Metastasis Reviews | Ausgabe 1/2020

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Abstract

Most children are surviving acute lymphoblastic leukemia (ALL) today. Yet, the emergence of cardiometabolic comorbidities in this population may impact long-term outcomes including the quality of life and lifespan. Obesity is a major driver of cardiometabolic disorders in the general population, and in ALL patients it is associated with increased risk of hypertension, dysglycemia, and febrile neutropenia when compared with lean ALL patients undergoing therapy. This systematic review aims to assess the current evidence for bariatric interventions to manage obesity in children with ALL. The primary outcome for this systematic review was the change in BMI z-score with implementation of the interventions studied. Literature searches were conducted in several databases. Ten publications addressing the study question were included in this review, and five studies were used in the meta-analysis to assess the impact of the bariatric interventions on obesity. The BMI z-score did not change significantly with the interventions. However, the quality of evidence was low, which precluded the recommendation of their use. In conclusion, prospective, rigorous, adequately powered, and high-quality longitudinal studies are urgently needed to deliver effective lifestyle interventions to children with ALL to treat and prevent obesity. These interventions, if successful, may improves cardiometabolic health outcomes and enhance the quality of life and life expectancy in children with ALL.

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Titel: Bariatric interventions in obesity treatment and prevention in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis
verfasst von: Kuan-Wen Wang
Salma Ladhani
Brianna Empringham
Carol Portwine
Adam Fleming
Laura Banfield
Janatani Balakumaran
Lisa Sarpong
E. Danielle Sims
Alexander Nicholas Popa
Lehana Thabane
M. Constantine Samaan
Publikationsdatum: 28.01.2020
Verlag: Springer US
Erschienen in: Cancer and Metastasis Reviews / Ausgabe 1/2020
Print ISSN: 0167-7659
Elektronische ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-020-09849-y

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Bariatric interventions in obesity treatment and prevention in pediatric acute lymphoblastic leukemia: a systematic review and meta-analysis

Abstract

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ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

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Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

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Abstract

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