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Local antibiotic delivery with demineralized bone matrix

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Abstract

A method of care for these infected nonunions is prolonged intravenous systemic antibiotic treatment and implantation of methyl methacrylate antibiotic carrier beads to delivery high local doses of antibiotics. This method requires a second surgery to remove the beads once the infection has cleared. Recent studies have investigated the use of biodegradable materials that have been impregnated with antibiotics as tools to treat bone infections. In the present study, human demineralized bone matrix (DBM) was investigated for its ability to be loaded with an antibiotic. The data presented herein demonstrates that this osteoinductive and biodegradable material can be loaded with gentamicin and release clinically relevant levels of the drug for at least 13 days in vitro. This study also demonstrates that the antibiotic loaded onto the graft has no adverse effects on the osteoinductive nature of the DBM as measured in vitro and in vivo. This bone void filler may represent a promising option for local antibiotic delivery in orthopedic applications.

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Acknowledgments

The authors would like to thank the donors and their families for their thankless gift of donated tissue, without which, this research would not have been possible. The authors would also like to thank RTI Biologics, Inc., for their continued support of this research.

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Authors and Affiliations

  1. Research and Development Group, RTI Biologics, 11621 Research Circle, Alachua, FL, 32616, USA

    Christine S. Lewis, Peter R. Supronowicz, Rasa M. Zhukauskas, Elise Gill & Ronald R. Cobb

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  1. Christine S. Lewis
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  2. Peter R. Supronowicz
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  3. Rasa M. Zhukauskas
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  4. Elise Gill
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  5. Ronald R. Cobb
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Correspondence to Christine S. Lewis.

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Lewis, C.S., Supronowicz, P.R., Zhukauskas, R.M. et al. Local antibiotic delivery with demineralized bone matrix. Cell Tissue Bank 13, 119–127 (2012). https://doi.org/10.1007/s10561-010-9236-y

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  • DOI: https://doi.org/10.1007/s10561-010-9236-y

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