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01.04.2015 | Research Paper

Growth pattern of colorectal liver metastasis as a marker of recurrence risk

verfasst von: R. L. Eefsen, P. B. Vermeulen, I. J. Christensen, O. D. Laerum, M. B. Mogensen, H. C. Rolff, G. G. Van den Eynden, G. Høyer-Hansen, K. Osterlind, B. Vainer, M. Illemann

Erschienen in: Clinical & Experimental Metastasis | Ausgabe 4/2015

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Abstract

Despite improved therapy of advanced colorectal cancer, the median overall survival (OS) is still low. A surgical removal has significantly improved survival, if lesions are entirely removed. The purpose of this retrospective explorative study was to evaluate the prognostic value of histological growth patterns (GP) in chemonaive and patients receiving neo-adjuvant therapy. Two-hundred-fifty-four patients who underwent liver resection of colorectal liver metastases between 2007 and 2011 were included in the study. Clinicopathological data and information on neo-adjuvant treatment were retrieved from patient and pathology records. Histological GP were evaluated and related to recurrence free and OS. Kaplan–Meier curves, log-rank test and Cox regression analysis were used. The 5-year OS was 41.8 % (95 % CI 33.8–49.8 %). Growth pattern evaluation of the largest liver metastasis was possible in 224 cases, with the following distribution: desmoplastic 63 patients (28.1 %); pushing 77 patients (34.4 %); replacement 28 patients (12.5 %); mixed 56 patients (25.0 %). The Kaplan–Meier analyses demonstrated that patients resected for liver metastases with desmoplastic growth pattern had a longer recurrence free survival (RFS) than patients resected for non-desmoplastic liver metastases (p = 0.05). When patients were stratified according to neo-adjuvant treatment in the multivariate Cox regression model, hazard ratios for RFS compared to desmoplastic were: pushing (HR = 1.37, 95 % CI 0.93–2.02, p = 0.116), replacement (HR = 2.16, 95 % CI 1.29–3.62, p = 0.003) and mixed (HR = 1.70, 95 % CI 1.12–2.59, p = 0.013). This was true for chemonaive patients as well as for patients who received neo-adjuvant treatment.

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Titel: Growth pattern of colorectal liver metastasis as a marker of recurrence risk
verfasst von: R. L. Eefsen
P. B. Vermeulen
I. J. Christensen
O. D. Laerum
M. B. Mogensen
H. C. Rolff
G. G. Van den Eynden
G. Høyer-Hansen
K. Osterlind
B. Vainer
M. Illemann
Publikationsdatum: 01.04.2015
Verlag: Springer Netherlands
Erschienen in: Clinical & Experimental Metastasis / Ausgabe 4/2015
Print ISSN: 0262-0898
Elektronische ISSN: 1573-7276
DOI: https://doi.org/10.1007/s10585-015-9715-4

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

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Growth pattern of colorectal liver metastasis as a marker of recurrence risk

Abstract

Neu im Fachgebiet Onkologie

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ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

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Update Onkologie

Springer Medizin

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