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Erschienen in: Digestive Diseases and Sciences 1/2010

01.01.2010 | Original Article

Chronic Abdominal Pain in Children Is Associated with High Prevalence of Abnormal Microbial Fermentation

verfasst von: Brynie Slome Collins, Henry C. Lin

Erschienen in: Digestive Diseases and Sciences | Ausgabe 1/2010

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Abstract

Background

Chronic abdominal pain (CAP) in children, a condition that accounts for approximately 25% of pediatric gastroenterology office visits, may be a precursor to irritable bowel syndrome in adults. Recently, small intestinal bacterial overgrowth (SIBO) has been reported in 78–84% of IBS patients regardless of their abdominal symptoms, compared to 20% in healthy controls.

Aims

The aim of this study was, therefore, to assess the prevalence of SIBO in children with CAP.

Methods

Seventy-five children aged 8–18 years diagnosed with CAP based on the Rome II criteria and 40 healthy controls were enrolled. All subjects underwent a lactulose breath hydrogen test (LBT) to assess for SIBO. Children with CAP also filled out symptom questionnaires.

Results

There was a 91% prevalence of an abnormal LBT suggestive of SIBO in the children with CAP and 35% in controls (odds ratio = 16.7, 95% confidence interval 6.0–57.5, P < 0.0001). A comparison of CAP children with a positive LBT to CAP children with a negative LBT revealed the former had significantly more “urgency to have a bowel movement” (P = 0.049) and experienced less “soiling” (P = 0.016) than those with a negative LBT. No significant differences were found between the two groups in terms of the location of their pain or any other associated symptoms.

Conclusions

Similar to adults with IBS, there is a significantly higher prevalence of SIBO in children with CAP. Randomized controlled studies are needed to determine if eradication of SIBO will lead to symptom improvement in these patients.
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Metadaten
Titel
Chronic Abdominal Pain in Children Is Associated with High Prevalence of Abnormal Microbial Fermentation
verfasst von
Brynie Slome Collins
Henry C. Lin
Publikationsdatum
01.01.2010
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 1/2010
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-009-1026-7

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