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Erschienen in:
01.10.2012 | Original Article
Long-Term Risk of Cholangitis in Patients with Metal Stents for Malignant Biliary Obstruction
Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2012
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Background
Patients with malignant biliary obstruction are commonly living longer than previously due to improved oncologic therapies, often exceeding expected times of self-expanding metal stent patency.
Aims
The purpose of this study was to assess the long-term risk and impact of cholangitis in these patients.
Methods
Retrospective review of electronic medical records at an academic medical center.
Results
One hundred and one patients had a self-expanding metal stent placed for malignant biliary obstruction. The median survival after SEMS was 214 days. Of these patients, 22 % developed at least one episode of cholangitis requiring inpatient admission, 20 % (9/45) of patients were hospitalized for cholangitis at 6 months, 40 % (8/20) at 1 year, and 75 % (3/4) at 2 years. All of the (8/8) patients receiving chemotherapy prior to hospitalization for cholangitis experienced delays in subsequent chemotherapy. Follow-up of 36 episodes of cholangitis revealed a 14 % 30-day mortality.
Conclusions
Cholangitis develops commonly in long-term survivors with self-expanding metal stents for malignant biliary obstruction, and is associated with delays in chemotherapy and a 14 % 30-day mortality.