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Digestive Diseases and Sciences

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01.10.2013 | Original Article

Relationship Between ¹³C-Aminopyrine Breath Test and the MELD Score and Its Long-Term Prognostic Use in Patients with Cirrhosis

verfasst von: Edoardo G. Giannini, Vincenzo Savarino

Erschienen in: Digestive Diseases and Sciences | Ausgabe 10/2013

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Abstract

Background

¹³C-Aminopyrine breath test (¹³C-ABT) is a non-invasive, dynamic, quantitative liver function test, and the model for end-stage liver disease (MELD) is a recognised biochemical score used to predict survival in patients with cirrhosis.

Aims

The purpose of this study was to evaluate the relationship between the ¹³C-ABT and MELD score in a cohort of cirrhotic patients and, moreover, to assess the prognostic value of ¹³C-ABT results in the same group of patients.

Patients and Methods

Forty-six patients with cirrhosis and without hepatocellular carcinoma who underwent ¹³C-ABT and who had at least 1-year follow-up were prospectively included in this study. MELD score was calculated at entry into the study in all patients. End-points of the study were 1-year liver-related death or liver transplantation.

Results

¹³C-ABT %dose/h at 30 min (%dose/h₃₀) results showed significant, inverse correlation with MELD scores (r = −0.414, P = 0.004). During 1-year follow-up nine patients died (19.6 %) and two were transplanted (4.3 %). Median ¹³C-ABT %dose/h₃₀ results (3.2 vs. 1.8) were significantly higher in patients who survived as compared to those who died or underwent transplantation (P = 0.04). Receiver operating characteristics curves showed that a ¹³C-ABT %dose/h₃₀ cut-off of 2.0 had the best accuracy (c-index = 0.717) in assessing 1-year prognosis.

Conclusions

We observed a correlation between a flow-independent quantitative liver function test and the MELD score, and found that the ¹³C-ABT may accurately provide long-term prognostic information in cirrhotic patients.

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Titel: Relationship Between 13C-Aminopyrine Breath Test and the MELD Score and Its Long-Term Prognostic Use in Patients with Cirrhosis
verfasst von: Edoardo G. Giannini
Vincenzo Savarino
Publikationsdatum: 01.10.2013
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 10/2013
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-013-2739-1

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Relationship Between ¹³C-Aminopyrine Breath Test and the MELD Score and Its Long-Term Prognostic Use in Patients with Cirrhosis

Abstract

Background

Aims

Patients and Methods

Results

Conclusions

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Sind Betablocker auch für ältere herzschwache Personen nützlich?

Kein Abstrich bei chronischen Wunden ohne Entzündungszeichen!

Manche Gestagene können das Risiko für Meningeome erhöhen

Stillende Frauen haben geringeres kardiovaskuläres Risiko

Update Innere Medizin

Springer Medizin

Abstract

Background

Aims

Patients and Methods

Results

Conclusions

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