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Erschienen in:
01.12.2015 | Review
Liver Metastasis from Colorectal Cancer in the Elderly: Is Surgery Justified?
Erschienen in: Digestive Diseases and Sciences | Ausgabe 12/2015
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Background
The elderly population with liver metastasis from colorectal cancer has been increasing. As the potentially curative treatment, the role of liver resection in the elderly remains undetermined.
Aims
This study provides a meta-analysis on the outcome of liver resection of colorectal liver metastasis in patients aged over 70.
Methods
PubMed, Embase, Ovid, Web of Science, and Cochrane databases from the years 2000 to 2015 were searched for eligible studies. Data on perioperative mortality, postoperative complications, and survival were collected.
Results
Twelve retrospective studies with a total of 11,285 patients (2498 elderly patients and 8787 younger patients) were identified. The elderly (>70 years old) were associated with a similar overall complication rate (30.5 vs. 28.0 %; OR 1.08; 95 % CI 0.91–1.28; p = 0.39) and a higher 30-day mortality (OR 1.92; 95 % CI 1.12–3.31; p = 0.02) after liver resection of colorectal liver metastasis (CRLM). The overall survival showed a significant difference in favor of the younger patients (HR 0.76; 95 % CI 0.65–0.89; p = 0.0007). However, with regard to disease-free survival, there was no significant difference between elderly and younger patients (HR 0.93; 95 % CI 0.82–1.06; p = 0.30).
Conclusion
Liver resection of CRLM is relatively safe in carefully selected elderly patients. Liver resection should be offered to selected elderly patients with CRLM.