Skip to main content

Advertisement

SpringerLink
Log in

Pattern visual evoked potentials in Japanese patients with multiple sclerosis without history of visual pathway involvement

  • Original Paper
  • Published:
Documenta Ophthalmologica Aims and scope Submit manuscript

Abstract

A delay of the peak latency of the pattern visual evoked cortical potentials (pVEP) is accepted as one of the paraclinical evidence for a diagnosis of multiple sclerosis (MS). The purpose of this study was to evaluate the pVEPs in Japanese patients with MS without a history of visual pathway involvement. We studied the medical records of 29 MS patients without any history of visual pathway involvement, and with visual acuity correctable to ≥20/20. The Goldmann visual fields, pupillary light reflexes, and optic disks were normal in all. pVEPs elicited by 3 rev/s (transient) and 12 rev/s (steady-state) were recorded from the MS patients and compared with those recorded from normal subjects. The latency of the P100 component of the transient pVEPs was significantly prolonged in 9/29 (31%) MS patients. A phase lag in the steady-state pVEPs was found in 6/29 (21%) MS patients, and the mean amplitude was significantly smaller. The incidence of cases with abnormal pVEPs is lower than that reported from Europe and United State. This difference is possibly due to racial differences, and the use of different criteria for diagnosing optic neuritis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Chiappa KH (1990) Pattern-shift evoked potentials In: Chiappa KH (ed) Evoked potentials in clinical medicine. Raven Press, New York p 111–172

    Google Scholar 

  2. Halliday AM (ed) (1993) Evoked potentials in clinical testing. 2nd edn. Churchill Livingstone, London

    Google Scholar 

  3. Halliday AM, McDonald WI, Mushin J (1973) Visual evoked responses in the diagnosis of multiple sclerosis. Br Med J 4:661–664

    Article  PubMed  CAS  Google Scholar 

  4. Asselman P, Feinsod M, Hoyt WF (1975) Subclinical optic neuropathy in multiple sclerosis. How early VER components reflect axon loss and conduction defects in optic pathways. J Neurol Neurosurg Psychiatry 38:1109–1114

    Google Scholar 

  5. Hoeppner T, Losas F (1978) Visual evoked responses and visual symptoms in multiple sclerosis. J Neurol Neurosurg Psychiatry 41:493–498

    PubMed  CAS  Google Scholar 

  6. Shibasaki H, Kuroiwa Y (1982) Pattern reversal visual evoked potentials in Japanese patient with multiple sclerosis. J Neurol Neurosurg Psychiatry 45:1139–1143

    PubMed  CAS  Google Scholar 

  7. Leys MJJ, Candaele CMLJ, De Rouck AF, Odom JV (1991) Detection of hidden visual loss in multiple sclerosis. Doc Ophthalmol 77:255–264

    Article  PubMed  CAS  Google Scholar 

  8. Pinckers A, Cruysberg JRM (1992) Color vision, visually evoked potentials, and lightness discrimination in patients with multiple sclerosis. Neuro Ophthalmol 12:251–256

    Google Scholar 

  9. Herbst H, Ketabi A, Their P, Dichgans J (1997) Comparison of psychophysical and evoked potential methods in the detection of deficits in multiple sclerosis. Electroencephalogr Clin Neurophysiol 104:82–90

    Article  PubMed  CAS  Google Scholar 

  10. Gronseth GS, Ashman EJ (2000) Practice parameter: the usefulness of evoked potentials in identifying clinically silent lesions in patients with suspected multiple sclerosis (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 54:1720–1725

    PubMed  CAS  Google Scholar 

  11. Davidson AW, Scott RF, Mitchell KW (2004) The effect of contrast reduction on pattern-reversal VEPs in suspected multiple sclerosis and optic neuritis. Doc Ophthalmol 109:157–161

    Article  PubMed  Google Scholar 

  12. Corallo G, Cicinelli S, Papadia M et al (2005) Conventional perimetry, short-wavelength automated perimetry. Frequency-doubling technology, and visual evoked potentials in the assessment of patients with multiple sclerosis. Eur J Ophthalmol 15:730–738

    PubMed  CAS  Google Scholar 

  13. Acar G, Ozakbas AG, Cakmakci H et al (2004) Visual evoked potential is superior to triple dose magnetic resonance imaging in the diagnosis of optic nerve involvement. Int J Neurosci 114:1025–1033

    Article  PubMed  Google Scholar 

  14. Poser CM, Paty DW, Scheinberg L et al (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231

    Article  PubMed  CAS  Google Scholar 

  15. McDonald WI, Compston A, Edan G et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121–127

    Article  PubMed  CAS  Google Scholar 

  16. Takasoh M, Adachi-Usami E, Mizota A (1998) Steady-state PVECP is superior to transient PVECP in the diagnosis of optic neuritis. Acta Ophthalmol Scand 76:230–233

    Article  PubMed  CAS  Google Scholar 

  17. Shibasaki H, McDonald WI, Kuroiwa Y (1981) Racial modification of clinical picture of multiple sclerosis: comparison between British and Japanese patients. J Neurol Sci 49:253–271

    Article  PubMed  CAS  Google Scholar 

  18. Alter M, Good J, Okihiro M (1973) Optic neuritis in oriental and Caucasians. Neurology 23:631–639

    PubMed  CAS  Google Scholar 

  19. Hely MA, McManis PG, Walsh JC et al (1986) Visual evoked responses and ophthalmological examination in optic neuritis. J Neurol Sci 75:275–283

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, 279-0021, Japan

    Atsushi Mizota

  2. Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, Chiba, Japan

    Noriko Asaumi, Michihiko Takasoh & Emiko Adachi-Usami

Authors
  1. Atsushi Mizota
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Noriko Asaumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michihiko Takasoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Emiko Adachi-Usami
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Atsushi Mizota.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mizota, A., Asaumi, N., Takasoh, M. et al. Pattern visual evoked potentials in Japanese patients with multiple sclerosis without history of visual pathway involvement. Doc Ophthalmol 115, 105–109 (2007). https://doi.org/10.1007/s10633-007-9062-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10633-007-9062-0

Keywords

Search

Navigation