Introduction
Methods
Patients
PD group | Control group |
p value | |
---|---|---|---|
Number of eyes | 38 | 38 | ns |
Age (years) | 60.9 ± 7.7 | 60.6 ± 7.9 | ns |
Sex (men/women) | 12/8 | 12/8 | ns |
PD duration (years) | 1.7 ± 1.0 | – | – |
Stage of PD (H–Y) | 1.1 ± 0.2 | – | – |
DBCVA (log MAR) | 0.01 ± 0.02 | 0.03 ± 0.08 | ns |
RT (µm) | 223.8 ± 14.9 | 213.8 ± 14.3 | ns |
RNFL thickness (µm) | |||
Temporal | 63.5 ± 14.4 | 61.5 ± 12.6 | ns |
Superior | 122.4 ± 17.4 | 115.2 ± 19.6 | ns |
Nasal | 79.2 ± 18.5 | 72.0 ± 15.0 | ns |
Inferior | 124.5 ± 17.2 | 119.3 ± 17.3 | ns |
Procedures
Dark-adapted ERGs
Light-adapted ERGs
Statistical analysis
Results
Wave | Group | N | M ± SD | Min | Med | Max | |
---|---|---|---|---|---|---|---|
Dark-adapted ERG (dim flash) | b-wave A (µV) | PD C | + − | 113.6 ± 44.5 134.7 ± 75.3 | 43.4 41.3 | 110.3 119.4 | 210.9 408.0 |
b-wave PT (ms) | PD C | + + | 119.7 ± 10.0 120.7 ± 7.3 | 105.0 102.0 | 119.0 121.0 | 132.5 140.0 | |
Dark-adapted ERG (strong flash) | a-wave A (µV) | PD C | + + |
137.5 ± 52.2***
#
179.9 ± 14.2***
#
|
11.5
58.1
|
144.3
182.4
|
237.0
292.5
|
a-wave PT (ms) | PD C | − + | 24.1 ± 1.9 23.8 ± 0.9 | 17.5 22.0 | 24.6 23.8 | 29.0 26.5 | |
b-wave A (µV) | PD C | + − | 428.8 ± 100.7 431.9 ± 101.9 | 212.4 261.2 | 417.4 414.6 | 611.4 685.3 | |
b-wave PT (ms) | PD C | − − | 48.1 ± 3.7 48.4 ± 3.2 | 44.0 42.0 | 47.5 47.3 | 60.5 53.5 | |
Dark-adapted ERG oscillatory potentials | OP1 | ||||||
A (µV) | PD C | + + | 28.2 ± 11.3 31.8 ± 13.6 | 8.3 10.3 | 29.6 29.0 | 48.7 58.8 | |
PT (ms) | PD C | − + |
21.5 ± 3.5***
#
19.2 ± 1.3***
#
|
18.5
16.5
|
20.0
19.0
|
31.0
22.0
| |
OP2 | |||||||
A (µV) | PD C | + + |
43.9 ± 19.2*
56.2 ± 25.2*
|
10.7
17.6
|
44.4
57.6
|
83.8
114.6
| |
PT (ms) | PD C | − − |
28.5 ± 3.2**
#
26.6 ± 1.3**
#
|
25.5
24.5
|
27.0
26.5
|
37.0
29.5
| |
OP3 | |||||||
A (µV) | PD C | + + |
34.5 ± 14.9
*^
43.9 ± 16.5
*^
|
7.2
15.9
|
33.8
41.1
|
75.7
76.4
| |
PT (ms) | PD C | − − |
35.2 ± 3.6
**^
33.4 ± 1.8
**^
|
31.0
30.0
|
34.0
33.0
|
44.5
39.5
| |
OP4 | |||||||
A (µV) | PD C | − − | 28.9 ± 19.9 23.5 ± 15.1 | 2.2 3.2 | 21.9 20.1 | 73.0 70.9 | |
PT (ms) | PD C | + − |
43.9 ± 3.4
*^
42.3 ± 3.6
*^
|
39.0
37.0
|
43.3
41.5
|
53.5
55.0
| |
Overall index (µV) | PD C | + + |
106.7 ± 36.9
*^
131.9 ± 47.0
*^
|
50.0
53.7
|
107.9
130.5
|
192.7
233.5
| |
Light-adapted ERG | a-wave A (µV) | PD C | + + | 32.1 ± 22.7 27.1 ± 14.2 | 4.8 1.1 | 30.6 26.2 | 88.2 66.1 |
a-wave PT (ms) | PD C | − + | 15.7 ± 1.5 15.5 ± 1.0 | 11.0 13.0 | 15.5 15.5 | 19.0 18.0 | |
b-wave A (µV) | PD C | + + |
85.9 ± 35.1
*^
107.8 ± 43.0
*^
|
29.5
42.6
|
88.9
103.4
|
160.5
229.4
| |
b-wave PT (ms) | PD C | − − | 30.8 ± 2.2 30.6 ± 1.3 | 28.5 28.0 | 29.5 30.8 | 41.5 32.5 | |
Light-adapted flicker ERG | A (µV) | PD C | + + | 59.9 ± 20.9 68.2 ± 24.1 | 27.4 26.3 | 61.5 65.3 | 97.0 120.0 |
PT (ms) | PD C | − + | 31.6 ± 4.0 30.5 ± 1.6 | 27.6 27.8 | 31.0 30.3 | 34.8 35.5 |
Visual symptoms | ERG—OPs | |
---|---|---|
↑ PT (n = 6/20) | normal PT (n = 14/20) | |
Difficulties in light adaptation | 3/6 (50 %) | 2/14 (14.3 %) |
Decreased contrast sensitivity | 3/6 (50 %) | 1/14 (7.1 %) |
Abnormalities of color vision | 1/6 (16.7 %) | 0/14 (0 %) |
Difficulties in smooth pursuit | 1/6 (16.7 %) | 0/14 (0 %) |