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European Journal of Epidemiology

Erschienen in:

01.02.2008 | RESPIRATOY DISEASES

Chronic obstructive pulmonary disease and mortality following hip fracture: a population-based cohort study

verfasst von: Cynthia de Luise, Michael Brimacombe, Lars Pedersen, Henrik Toft Sørensen

Erschienen in: European Journal of Epidemiology | Ausgabe 2/2008

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Abstract

Introduction: Mortality rates after hip fracture have not declined in 20 years. We assessed the impact of chronic obstructive pulmonary disease (COPD) on mortality after hip fracture, and compared mortality in this cohort to persons without hip fracture in a population-based prospective cohort study. Methods: Using Danish health care registries, we identified persons ≥40 years old with first-time hospitalization for hip fracture between 1/1/1998 and 1/31/2003. Hospitalization for COPD was assessed from hospital discharge registries. Using Cox regression, we computed relative risks (RR) and 95% confidence intervals (CI) for mortality endpoints among persons with COPD compared to persons without COPD. Mortality following hip fracture was also compared to age and gender matched controls without hip fracture. Results: We identified 11, 985 persons with first-time hospitalization for hip fracture; 771 (6.4%) had a diagnosis of COPD. Average follow up was 22 months. Compared to persons without COPD, mortality following hip fracture in persons with COPD was RR = 1.58 (95% CI 1.30–1.90) at 30 days, RR = 1.52 (95% CI 1.30–1.77) at 90–days, RR = 1.58 (95% CI 1.40–1.78) at 1 year, and RR = 1.71 (95% CI 1.55–1.88) overall. The 1-year mortality in persons with hip fracture and COPD was approximately 3–5 times greater than in controls without hip fracture. Conclusions: In this cohort, persons with COPD have a 60–70% higher risk of death following hip fracture than those without COPD. In addition, hip fracture and COPD increased 1-year mortality 3–5 times that of persons without hip fracture.

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Cooper C, Campion G, Melton III LJ. Hip fractures in the elderly: A world-wide projection. Osteoporos Int 1992;2:285–89.PubMedCrossRef

Samelson E, Zhang Y, Kiel DP, Hannan MT, Felson DT. Effect of birth cohort on risk of hip fracture: Age- specific incidence rates in the Framingham Study. Am J Pub Health 2002;92:858–62.PubMed

Gullberg B, Johnell O, Kanis JA. Worldwide projections for hip fracture. Osteoporos Int 1997;7(5):407–13.PubMedCrossRef

Nettleman M, Aisip J, Schrader M, Schulte M. Predictors of mortality after acute hip fracture. J Gen Intern Med 1996;11:765–67.PubMedCrossRef

Magaziner J, Simonsick EM, Kashner TM, Hebel JR, Kenzora JE. Excess mortality attributable to white women age 70 or older. Am J Pub Health 1997;87:1630–36.PubMedCrossRef

Poor G, Atkinson EJ, O’Fallon WM, Melton LJ. Determinants of reduced survival following hip fracture in men. Clin Orthop 1995;319:260–65.PubMed

Barrett J, Baron JA, Beach ML. Mortality and pulmonary embolism after fracture in the elderly. Osteoporos Int 2003;14:889–94.PubMedCrossRef

Empana J, Dargent-Molina P, Breart G for the EPIDOS Group. Effect of hip fracture on mortality in elderly women: The EPIDOS Prospective Study. J Am Geriatr Soc 2004;52:685–90.PubMedCrossRef

Roche J, Wenn RT, Sahota O, Moran CG. Effect of comorbidities and postoperative complications on mortality after hip fracture in elderly people: prospective observational cohort study. BMJ 2005;331:1374–76.PubMedCrossRef

10.

Johnell O, Kanis JA, Odén A, Sernbo I, Redlund-Johnell I, Petterson C et al. Mortality after osteoporotic fractures. Osteoporos Int 2004;15:38–42.PubMedCrossRef

11.

Meyer H, Tverdal A, Falch JA, Pedersen JI. Factors associated with mortality after hip fracture. Osteoporos Int 2000;11:228–32.PubMedCrossRef

12.

Farahmand B, Michaëlsson K, Ahlbom A, Ljunghall S, Baron JA. Survival after hip fracture. Osteoporos Int 2005;16:1583–90.PubMedCrossRef

13.

Mannino D. Epidemiology, prevalence, morbidity and mortality, and disease heterogeneity. CHEST 2002;121:121S–126S.PubMedCrossRef

14.

Van Staa T, Leufkens HGM, Cooper C. Use of inhaled corticosteroids and risk of fractures. J Bone Mineral Res 2001;16:581–88.CrossRef

15.

Rejnmark L, Olsen ML, Johnsen JP, Vestergaard P, Sørensen HT, Mosekilde L. Hip fracture in statin users: a population-based Danish case–control study. Osteoporos Int 2004;15:452–58.PubMed

16.

Vestergaard P, Olsen ML, Johnsen SP, Rejnmark L, Sørensen HT. Corticosteroid use and risk of hip fracture: a population based case–control study in Denmark. J of Intern Med 2003;254:486–93.CrossRef

17.

de Luise C, Lanes SF, Jacobsen J, Pedersen L, Sørensen HT. Cardiovascular and respiratory hospitalizations and mortality among users of tiotropium in Denmark. Eur J Epidemiol 2007;DOI:10.1007/s10654-007-9106.

18.

Sørensen H. Regional administrative health registries as a resource in clinical epidemiology. Int J Risk Safety Med 1997;10:1–22.

19.

Andersen T, Madsen M, Jørgensen J, Mellemkjoer L, Olsen JH. The Danish National Hospital Register. A valuable source of data for modern health sciences. Dan Med Bull 1999;46:263–68.PubMed

20.

Pedersen C, Gøtzsche H, Møller JØ, Mortensen PB. The Danish Civil Registration System. Dan Med Bull 2006;53:441–49.PubMed

21.

Charlson M, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373–83.PubMedCrossRef

22.

de Groot V, Beckerman H, Lankhorst GJ, Bouter LM. How to measure comorbidity. A critical review of available methods. J Clin Epidemiol 2003;56:221–29.PubMedCrossRef

23.

Deyo R, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613–19.PubMedCrossRef

24.

Gaist D, Hallas J. The Danish prescription registries. Dan Med Bull 1997;44:445–48.PubMed

25.

Capella D. Drug Utilization Studies: Methods and Uses. In: Descriptive tools, analysis. European Series. Dukes M (ed). Copenhagen: WHO Regional Publicationsl 1993;35:55–58.

26.

SAS Institute Inc, SAS, version 9.1: Cary, NC.

27.

Connors A, Dawson NV, Thomas C, Harrell FE, Desbiens N, Fulkerson WJ et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. Am J Respir Crit Care Med 1996;154:959–67.PubMed

28.

Fuso L, Incalzi RA, Pistelli R, Muzzolon R, Valente S, Pagliari G et al. Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease. Am J Med 1995;98:272–77.PubMedCrossRef

29.

Seneff M, Wagner DP, Wagner RP, Zimmerman JE, Knaus WA. Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA 1995;274:1852–57.PubMedCrossRef

30.

Groenewegen KH, Schols AM, Wouters EF. Mortality and mortality-related factors after hospitalization for acute exacerbation of COPD. CHEST 2003;124:459–67.PubMedCrossRef

31.

Gulliford M, Charlton J, Latinovic R. Risk of diabetes associated with prescribed glucocorticoids in a large population. Diabetes Care 2006;29(12):2728–29.PubMedCrossRef

32.

McEvoy C, Niewoehner DE. Adverse Effects of Corticosteroid Therapy for COPD: A Critical Review. CHEST 1997;111:732–43.PubMedCrossRef

33.

Hansell A, Walk JA, Soriano JB. What do chronic obstructive pulmonary disease patients die from? A multiple cause coding analysis. Eur Respir J 2003;22:809–14.PubMedCrossRef

34.

Mannino D, Brown C, Giovino GA. Obstructive lung disease in the United States from 1979 to 1993: an analysis using multiple cause mortality data. Am J Respir Crit Care Med 1997;156:814–18.PubMed

35.

Holguin F, Folch E, Redd SC, Mannino DM. Comorbidity and mortality in COPD-related hospitalizations in the United States, 1979 to 2001. CHEST 2005;128:2005–2011.PubMedCrossRef

36.

Camilli A, Robbins DR, Lebowitz MD. Death certificate reporting of confirmed airway obstructive disease. Am J Epidemiol 1991;133:795–800.PubMed

37.

Huiart L, Ernst P, Suissa S. Cardiovascular morbidity and mortality in COPD. CHEST 2005;128:2640–46.PubMedCrossRef

38.

Anthonisen N, Connett JE, Enright PL, Manfreda J. Lung Health Study Research Group Hospitalization and mortality in the Lung Health Study. Am J Respir Crit Care Med 2002;166:333–39.PubMedCrossRef

39.

Sin D, Anthonisen NR, Soriano JB, Agusti AG. Mortality in COPD: role of comorbidities. Eur Resp J 2006;28:1245–57.CrossRef

40.

Soriano J, Visick GT, Muellerova H, Payvandi N, Hansell AL. Patterns of comorbiditiees in newly diagnosed COPD and asthma in primary care. CHEST 2005;128:2099–2107.PubMedCrossRef

41.

Strom K. Survival in patients with chronic obstructive pulmonary disease receiving long-term domiciliary oxygen therapy. Am J Respir Crit Care Med 1993;147:585–91.

42.

Strom K. Oral corticosteroid treatment during long-term oxygen therapy in chronic obstructive pulmonary disease: a risk factor for hospitalization and mortality in women. Respir Med 1998;92:50–56.PubMedCrossRef

43.

Schols A, Wesseling G, Kester AD, de Vries G, Mostert R, Slangen J et al. Dose dependent increase mortality risk in COPD patients treated with oral glucocorticosteroids. Eur Respir J 2001;17:337–42.PubMedCrossRef

44.

Department of Clinical Epidemiology, A.U., Kronisk obstruktiv lungesygdom I Nordjyllands, Viborg og Århus Amter 1994–2004. Forekomst og prognose. 2005.

45.

Baron J, Barrett J, McLerran D, Fisher ES. Internal validation of Medicare claims data. Epidemiology 1994;5(5):541–44.PubMed

46.

Fisher E, Whaley FS, Krushat WM, Malenka DJ, Fleming C, et al. The accuracy of Medicare’s hospital claims data: progress has been made, but problems remain. Am J Public Health 1992;82:243–48.PubMed

47.

Rothman K, Greenland S. Precision and validity of studies. In: Modern Epidemiology. 2nd ed. Rothman K, Greenland S (eds). Philadelphia: Lippencott-Raven, 1998. 126–32.

48.

Sundhedsstyrelsen. Monitoring smoking habits in the Danish population. 2005 [cited Oct 26, 2007];Available from: http://www.sst.dk/upload/forebyggelse/cff/tobak/tabeller_2005/kryds2005_alle.pdf.

49.

Mannino D, Homa DM, Akinbami LJ, Ford ES, Redd SC. Chronic Obstructive Pulmonary Disease Surveillance - United States, 1971–2000. MMWR 2002;51(SS06):1–16.

Titel: Chronic obstructive pulmonary disease and mortality following hip fracture: a population-based cohort study
verfasst von: Cynthia de Luise
Michael Brimacombe
Lars Pedersen
Henrik Toft Sørensen
Publikationsdatum: 01.02.2008
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 2/2008
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-007-9211-5

Springer Medizin

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