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European Journal of Epidemiology

Erschienen in:

01.03.2008 | RESPIRATORY DISEASES

Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults

verfasst von: Iris Kompauer, Hans Demmelmair, Berthold Koletzko, Gabriele Bolte, Jakob Linseisen, Joachim Heinrich

Erschienen in: European Journal of Epidemiology | Ausgabe 3/2008

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Abstract

Background The dietary intake of certain fatty acids might have an impact on inflammatory processes in the lung and therefore contribute to the development of lung diseases like asthma or COPD. Methods In this study data from a population based cross-sectional study on respirator y health including measurement of fatty acids in serum phospholipids of 593 adults between 20 and 64 years of age were analyzed. Results Statistically significant positive associations were found between percentage predicted FEV₁ (P = 0.0085) and FVC (P = 0.0267) and docosahexaenoic acid concentration in serum phospholipids in men. Dihomo-γ-linolenic acid content in serum phospholipids was significantly negatively associated with percentage predicted FEV₁ (P = 0.0003) and FVC (P = 0.0045) and transformed dose-response slopes (P = 0.0488) in men. Palmitoleic acid was negatively associated with percentage predicted FEV₁ (P = 0.0037) and FVC (P = 0.0029) in men. Other fatty acids in serum phospholipids did not consistently affect lung function parameters or bronchial hyperreactivity. Conclusion A high concentration of docosahexaenoic acid in serum phospholipids may have a protective effect on lung function. Because this long-chain n-3 polyunsaturated fatty acid is almost exclusively derived from marine oils, fish might have a beneficial effect on lung diseases.

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Titel: Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults
verfasst von: Iris Kompauer
Hans Demmelmair
Berthold Koletzko
Gabriele Bolte
Jakob Linseisen
Joachim Heinrich
Publikationsdatum: 01.03.2008
Verlag: Springer Netherlands
Erschienen in: European Journal of Epidemiology / Ausgabe 3/2008
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI: https://doi.org/10.1007/s10654-007-9218-y

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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