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Erschienen in: European Journal of Epidemiology 8/2009

01.08.2009 | CARDIOVASCULAR DISEASE

Impact of risk factors for non-fatal acute myocardial infarction

verfasst von: Andreia Oliveira, Henrique Barros, Ana Azevedo, Joana Bastos, Carla Lopes

Erschienen in: European Journal of Epidemiology | Ausgabe 8/2009

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Abstract

The impact of risk factors for acute myocardial infarction (AMI) strongly differs across populations and most studies do not consider age as an effect modifier. This study aims to estimate the population attributable fractions (PAFs) of established risk factors for non-fatal AMI, considering age stratification, within a population-based case–control study of Portuguese men. Cases were male patients consecutively admitted with an incident AMI, during 1999–2003 (n = 638) and controls were a representative sample of the non-institutionalized Porto, Portugal in-habitants (n = 851). PAFs were derived by the equation: PAF = 1 − Σ (ρ/R), in which ρ is the proportion of cases in each exposure stratum and R is the adjusted odds ratio. PAFs were obtained for the individual effect of each factor and for combinations of them, after allowance for confounding. High waist-to-hip ratio (>0.90), smoking and lower education levels (0–4 years) had the highest PAFs among men aged ≤45 years: 81.2% (95% CI: 71.2–88.2), 63.5% (95% CI: 42.0–80.6) and 53.8% (95% CI: 40.9–66.2), respectively. For the oldest men, high waist-to-hip ratio (PAF = 88.7%, 95% CI: 77.6–94.7) and lack of leisure-time physical activity (PAF = 44.8%, 95% CI: 32.0–58.2) were the risk factors with the highest impact. Lifestyles explained 77.2% (95% CI: 53.4–90.9) of young myocardial infarction cases and 77.6% (95% CI: 65.3–86.4) of the cases aged >45 years. Preventive targeted interventions to decrease the prevalence of such modifiable risk factors would likely reduce morbidity and mortality of cardiovascular events and related conditions.
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Metadaten
Titel
Impact of risk factors for non-fatal acute myocardial infarction
verfasst von
Andreia Oliveira
Henrique Barros
Ana Azevedo
Joana Bastos
Carla Lopes
Publikationsdatum
01.08.2009
Verlag
Springer Netherlands
Erschienen in
European Journal of Epidemiology / Ausgabe 8/2009
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-009-9352-9

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