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Erschienen in: European Journal of Epidemiology 1/2012

01.01.2012 | OBESITY

Intergenerational change and familial aggregation of body mass index

verfasst von: Paul C. D. Johnson, Jennifer Logue, Alex McConnachie, Niveen M. E. Abu-Rmeileh, Carole Hart, Mark N. Upton, Mike Lean, Naveed Sattar, Graham Watt

Erschienen in: European Journal of Epidemiology | Ausgabe 1/2012

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Abstract

The relationship between parental BMI and that of their adult offspring, when increased adiposity can become a clinical issue, is unknown. We investigated the intergenerational change in body mass index (BMI) distribution, and examined the sex-specific relationship between parental and adult offspring BMI. Intergenerational change in the distribution of adjusted BMI in 1,443 complete families (both parents and at least one offspring) with 2,286 offspring (1,263 daughters and 1,023 sons) from the west of Scotland, UK, was investigated using quantile regression. Familial correlations were estimated from linear mixed effects regression models. The distribution of BMI showed little intergenerational change in the normal range (<25 kg/m2), decreasing overweightness (25–<30 kg/m2) and increasing obesity (≥30 kg/m2). Median BMI was static across generations in males and decreased in females by 0.4 (95% CI: 0.0, 0.7) kg/m2; the 95th percentile increased by 2.2 (1.1, 3.2) kg/m2 in males and 2.7 (1.4, 3.9) kg/m2 in females. Mothers’ BMI was more strongly associated with daughters’ BMI than was fathers’ (correlation coefficient (95% CI): mothers 0.31 (0.27, 0.36), fathers 0.19 (0.14, 0.25); P = 0.001). Mothers’ and fathers’ BMI were equally correlated with sons’ BMI (correlation coefficient: mothers 0.28 (0.22, 0.33), fathers 0.27 (0.22, 0.33). The increase in BMI between generations was concentrated at the upper end of the distribution. This, alongside the strong parent-offspring correlation, suggests that the increase in BMI is disproportionally greater among offspring of heavier parents. Familial influences on BMI among middle-aged women appear significantly stronger from mothers than fathers.
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Literatur
1.
Zurück zum Zitat Government Office for Science. Foresight. Tackling obesities: future choices. Oct 17 2010. Government Office for Science. Foresight. Tackling obesities: future choices. Oct 17 2010.
2.
Zurück zum Zitat Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295(13):1549–55.PubMedCrossRef Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295(13):1549–55.PubMedCrossRef
3.
Zurück zum Zitat Wang Y, Beydoun MA, Liang L, et al. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring). 2008;16(10):2323–30.CrossRef Wang Y, Beydoun MA, Liang L, et al. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring). 2008;16(10):2323–30.CrossRef
4.
Zurück zum Zitat Abu-Rmeileh NM, Hart CL, McConnachie A, et al. Contribution of Midparental BMI and other determinants of obesity in adult offspring. Obesity (Silver Spring). 2008;16(6):1388–93.CrossRef Abu-Rmeileh NM, Hart CL, McConnachie A, et al. Contribution of Midparental BMI and other determinants of obesity in adult offspring. Obesity (Silver Spring). 2008;16(6):1388–93.CrossRef
5.
Zurück zum Zitat Perez-Pastor EM, Metcalf BS, Hosking J, et al. Assortative weight gain in mother-daughter and father-son pairs: an emerging source of childhood obesity. Longitudinal study of trios (EarlyBird 43). Int J Obes (Lond). 2009;33(7):727–35.CrossRef Perez-Pastor EM, Metcalf BS, Hosking J, et al. Assortative weight gain in mother-daughter and father-son pairs: an emerging source of childhood obesity. Longitudinal study of trios (EarlyBird 43). Int J Obes (Lond). 2009;33(7):727–35.CrossRef
6.
Zurück zum Zitat Leary S, Davey SG, Ness A. No evidence of large differences in mother-daughter and father-son body mass index concordance in a large UK birth cohort. Int J Obes (Lond). 2010;34(7):1191–2.CrossRef Leary S, Davey SG, Ness A. No evidence of large differences in mother-daughter and father-son body mass index concordance in a large UK birth cohort. Int J Obes (Lond). 2010;34(7):1191–2.CrossRef
7.
Zurück zum Zitat Hawthorne VM, Watt GC, Hart CL, et al. Cardiorespiratory disease in men and women in urban Scotland: baseline characteristics of the Renfrew/Paisley (midspan) study population. Scott Med J. 1995;40(4):102–7.PubMed Hawthorne VM, Watt GC, Hart CL, et al. Cardiorespiratory disease in men and women in urban Scotland: baseline characteristics of the Renfrew/Paisley (midspan) study population. Scott Med J. 1995;40(4):102–7.PubMed
8.
Zurück zum Zitat Upton MN, McConnachie A, McSharry C, et al. Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring. BMJ. 2000;321(7253):88–92.PubMedCrossRef Upton MN, McConnachie A, McSharry C, et al. Intergenerational 20 year trends in the prevalence of asthma and hay fever in adults: the Midspan family study surveys of parents and offspring. BMJ. 2000;321(7253):88–92.PubMedCrossRef
9.
Zurück zum Zitat Hart C, McConnachie A, Upton M, et al. Risk factors in the Midspan family study by social class in childhood and adulthood. Int J Epidemiol. 2008;37(3):604–14.PubMedCrossRef Hart C, McConnachie A, Upton M, et al. Risk factors in the Midspan family study by social class in childhood and adulthood. Int J Epidemiol. 2008;37(3):604–14.PubMedCrossRef
10.
Zurück zum Zitat General Register Office. Classification of occupations 1966. London: HMSO; 1966. p. 1–148. General Register Office. Classification of occupations 1966. London: HMSO; 1966. p. 1–148.
11.
Zurück zum Zitat General Register Office. Classification of occupations 1990. London: HMSO; 1990. General Register Office. Classification of occupations 1990. London: HMSO; 1990.
12.
Zurück zum Zitat Silverman BW. Density estimation. London: Chapman and Hall; 1986. Silverman BW. Density estimation. London: Chapman and Hall; 1986.
13.
Zurück zum Zitat Rasbash J, Brown W, Healy M, et al. MLwiN Version 1.1. Multilevel models project; 2011. Rasbash J, Brown W, Healy M, et al. MLwiN Version 1.1. Multilevel models project; 2011.
14.
Zurück zum Zitat R Development Core Team. R: A language and environment for statistical computing; 2009. R Development Core Team. R: A language and environment for statistical computing; 2009.
15.
Zurück zum Zitat Roger Koenker. quantreg: Quantile regression. R package version 4.50; 2010. Roger Koenker. quantreg: Quantile regression. R package version 4.50; 2010.
16.
Zurück zum Zitat Harrell Jr FE. Hmisc: Harrell miscellaneous. R package version 3.7-0; 2009. Harrell Jr FE. Hmisc: Harrell miscellaneous. R package version 3.7-0; 2009.
17.
Zurück zum Zitat Clemons T. A look at the inheritance of height using regression toward the mean. Hum Biol. 2000;72(3):447–54.PubMed Clemons T. A look at the inheritance of height using regression toward the mean. Hum Biol. 2000;72(3):447–54.PubMed
18.
Zurück zum Zitat Davey SG, Steer C, Leary S, et al. Is there an intrauterine influence on obesity? Evidence from parent child associations in the Avon Longitudinal Study of Parents and Children (ALSPAC). Arch Dis Child. 2007;92(10):876–80.CrossRef Davey SG, Steer C, Leary S, et al. Is there an intrauterine influence on obesity? Evidence from parent child associations in the Avon Longitudinal Study of Parents and Children (ALSPAC). Arch Dis Child. 2007;92(10):876–80.CrossRef
19.
Zurück zum Zitat Flegal KM, Troiano RP. Changes in the distribution of body mass index of adults and children in the US population. Int J Obes Relat Metab Disord. 2000;24(7):807–18.PubMedCrossRef Flegal KM, Troiano RP. Changes in the distribution of body mass index of adults and children in the US population. Int J Obes Relat Metab Disord. 2000;24(7):807–18.PubMedCrossRef
20.
Zurück zum Zitat Micciolo R, Di FV, Fantin F et al. Prevalence of overweight and obesity in Italy (2001–2008): is there a rising obesity epidemic? Ann Epidemiol. 2010;20(4):258–64. Micciolo R, Di FV, Fantin F et al. Prevalence of overweight and obesity in Italy (2001–2008): is there a rising obesity epidemic? Ann Epidemiol. 2010;20(4):258–64.
21.
Zurück zum Zitat Rose G, Khaw KT, Marmot M. Rose’s strategy of preventative medicine. Revised Edition ed. Oxford: Oxford University Press; 2008. Rose G, Khaw KT, Marmot M. Rose’s strategy of preventative medicine. Revised Edition ed. Oxford: Oxford University Press; 2008.
22.
Zurück zum Zitat Barnett AG, van der Pols JC, Dobson AJ. Regression to the mean: what it is and how to deal with it. Int J Epidemiol. 2005;34(1):215–20.PubMedCrossRef Barnett AG, van der Pols JC, Dobson AJ. Regression to the mean: what it is and how to deal with it. Int J Epidemiol. 2005;34(1):215–20.PubMedCrossRef
23.
Zurück zum Zitat Hotelling H. Review of the triumph of mediocrity in business. J Am Stat Assoc. 1933;28:463–5. Hotelling H. Review of the triumph of mediocrity in business. J Am Stat Assoc. 1933;28:463–5.
24.
Zurück zum Zitat Davey SG, Sterne JA, Fraser A, et al. The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ 2009;339:b5043. Davey SG, Sterne JA, Fraser A, et al. The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study. BMJ 2009;339:b5043.
25.
Zurück zum Zitat Herskind AM, McGue M, Sorensen TI, et al. Sex and age specific assessment of genetic and environmental influences on body mass index in twins. Int J Obes Relat Metab Disord. 1996;20(2):106–13.PubMed Herskind AM, McGue M, Sorensen TI, et al. Sex and age specific assessment of genetic and environmental influences on body mass index in twins. Int J Obes Relat Metab Disord. 1996;20(2):106–13.PubMed
26.
Zurück zum Zitat Stunkard AJ, Harris JR, Pedersen NL, et al. The body-mass index of twins who have been reared apart. N Engl J Med. 1990;322(21):1483–7.PubMedCrossRef Stunkard AJ, Harris JR, Pedersen NL, et al. The body-mass index of twins who have been reared apart. N Engl J Med. 1990;322(21):1483–7.PubMedCrossRef
27.
Zurück zum Zitat Wardle J, Carnell S, Haworth CM, et al. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr. 2008;87(2):398–404.PubMed Wardle J, Carnell S, Haworth CM, et al. Evidence for a strong genetic influence on childhood adiposity despite the force of the obesogenic environment. Am J Clin Nutr. 2008;87(2):398–404.PubMed
28.
Zurück zum Zitat Cecil JE, Tavendale R, Watt P, et al. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008;359(24):2558–66.PubMedCrossRef Cecil JE, Tavendale R, Watt P, et al. An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med. 2008;359(24):2558–66.PubMedCrossRef
29.
Zurück zum Zitat Bauer F, Elbers CC, Adan RA, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90(4):951–9.PubMedCrossRef Bauer F, Elbers CC, Adan RA, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90(4):951–9.PubMedCrossRef
30.
Zurück zum Zitat Power C, Graham H, Due P, et al. The contribution of childhood and adult socioeconomic position to adult obesity and smoking behaviour: an international comparison. Int J Epidemiol. 2005;34(2):335–44.PubMedCrossRef Power C, Graham H, Due P, et al. The contribution of childhood and adult socioeconomic position to adult obesity and smoking behaviour: an international comparison. Int J Epidemiol. 2005;34(2):335–44.PubMedCrossRef
31.
Zurück zum Zitat Shelton NJ. What not to eat: inequalities in healthy eating behaviour, evidence from the 1998 Scottish Health Survey. J Public Health (Oxf). 2005;27(1):36–44.CrossRef Shelton NJ. What not to eat: inequalities in healthy eating behaviour, evidence from the 1998 Scottish Health Survey. J Public Health (Oxf). 2005;27(1):36–44.CrossRef
32.
Zurück zum Zitat Macdonald L, Cummins S, Macintyre S. Neighbourhood fast food environment and area deprivation-substitution or concentration? Appetite. 2007;49(1):251–4.PubMedCrossRef Macdonald L, Cummins S, Macintyre S. Neighbourhood fast food environment and area deprivation-substitution or concentration? Appetite. 2007;49(1):251–4.PubMedCrossRef
Metadaten
Titel
Intergenerational change and familial aggregation of body mass index
verfasst von
Paul C. D. Johnson
Jennifer Logue
Alex McConnachie
Niveen M. E. Abu-Rmeileh
Carole Hart
Mark N. Upton
Mike Lean
Naveed Sattar
Graham Watt
Publikationsdatum
01.01.2012
Verlag
Springer Netherlands
Erschienen in
European Journal of Epidemiology / Ausgabe 1/2012
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-011-9639-5

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