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Erschienen in: European Journal of Epidemiology 11/2012

01.11.2012 | CARDIOVASCULAR DISEASE

Sex-related differences in prognosis after myocardial infarction: changes from 1978 to 2007

verfasst von: María Grau, Cristina Sala, Joan Sala, Rafael Masia, Joan Vila, Isaac Subirana, Rafel Ramos, Roberto Elosua, Ramón Brugada, Jaume Marrugat

Erschienen in: European Journal of Epidemiology | Ausgabe 11/2012

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Abstract

Women with myocardial infarction (MI) have shown a 28-day survival disadvantage compared with men. However, results were less consistent when considering long-term mortality in 28-day survivors. The aim was to estimate the trends for sex-related differences in the three endpoints considered for this study: (1) 28-day mortality or severe ventricular dysfunction (acute pulmonary oedema or cardiogenic shock) during the hospital stay, (2) 28-day mortality and (3) two-year cardiovascular mortality or non-fatal MI in 28-day survivors after a first MI. A cohort of 3,982 consecutive patients with first Q-wave MI admitted to a university tertiary reference hospital between 1978 and 2007 was followed for 2 years. Short-term prognosis improved in women over the studied period; similar rates were observed in both sexes in the 2000s. After adjusting for age, co-morbidities and anterior location of MI, female sex had an odds ratio = 1.71 (95 % confidence interval [CI] 1.34–2.17) of short-term severe MI or death over the studied period. Overall, sex differences in long-term prognosis remained similar over the studied period (hazard ratio = 1.40; 95 % CI 1.02–1.91). In conclusion, short-term prognosis improved over the past 30 years for first Q-wave MI patients, becoming similar for both men and women in the most recent decade. Long-term prognosis did not improve in either men or women, indicating that secondary prevention should be reinforced to achieve consistent reductions in the number of cardiovascular events.
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Metadaten
Titel
Sex-related differences in prognosis after myocardial infarction: changes from 1978 to 2007
verfasst von
María Grau
Cristina Sala
Joan Sala
Rafael Masia
Joan Vila
Isaac Subirana
Rafel Ramos
Roberto Elosua
Ramón Brugada
Jaume Marrugat
Publikationsdatum
01.11.2012
Verlag
Springer Netherlands
Erschienen in
European Journal of Epidemiology / Ausgabe 11/2012
Print ISSN: 0393-2990
Elektronische ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-012-9712-8

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