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Erschienen in: Familial Cancer 1/2012

01.03.2012 | Original Article

First degree relatives and familial aggregation of gastric cancer: who to choose for control in case–control studies?

verfasst von: Ricardo Marcos-Pinto, Mário Dinis-Ribeiro, Fátima Carneiro, José Carlos Machado, Ceu Figueiredo, Celso A. Reis, José Ferreira, Jorge Areias

Erschienen in: Familial Cancer | Ausgabe 1/2012

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Abstract

Gastric carcinogenesis is a multifactorial process involving host gene and environmental interactions. Diverse case–control studies using different types of controls addressed the familial aggregation role for gastric cancer development. Our aim is to discuss the advantages and expected bias according to the different type of eligible controls. A PubMed search of papers on a query on first degree relatives of gastric cancer patients was conducted. The retrieved studies were evaluated regarding quality based on STROBE checklist. Data concerning risk of premalignant lesions and Helicobacter pylori infection was retrieved as the type of controls used on each study. Nine case–control studies were selected. A variety of controls were used ranging from general population to dyspeptic patients and spouses of the cases. We have observed that, independently of the type of control, the risk for the prevalence of premalignant lesions and H. pylori infection was higher for the cases. However, all of the evaluated case–control studies were average quality studies (mean 28 out of 45), with a small number of cases and controls (range from 39 to 300). Furthermore, concerning gene–environment interaction, each of the discussed type of control (general population, dyspeptic, spouse and neighbor) has potential advantages and disadvantages. The current data suggests that selection of any type of the aforementioned controls is feasible and seems to be mainly related to the feasibility of recruitment more than the genetic or environmental backgrounds. General population and dyspeptic patients would be equally appropriate for studies on familial aggregation of gastric cancer. Nevertheless, high-quality cohort studies are needed to validate this assumption.
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Metadaten
Titel
First degree relatives and familial aggregation of gastric cancer: who to choose for control in case–control studies?
verfasst von
Ricardo Marcos-Pinto
Mário Dinis-Ribeiro
Fátima Carneiro
José Carlos Machado
Ceu Figueiredo
Celso A. Reis
José Ferreira
Jorge Areias
Publikationsdatum
01.03.2012
Verlag
Springer Netherlands
Erschienen in
Familial Cancer / Ausgabe 1/2012
Print ISSN: 1389-9600
Elektronische ISSN: 1573-7292
DOI
https://doi.org/10.1007/s10689-011-9488-0

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